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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SH3GL3

Summary

GeneID

6457

Symbol

SH3GL3

Synonyms

Description

SH3-domain GRB2-like 3

Locus tag

Gene type

protein-coding

Map location

15q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0594

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

GO:0008289

lipid binding

IEA

GO:0042802

identical protein binding

IPI

16115810

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007417

central nervous system development

TAS

Brain (GO term level: 6)

9169142

GO:0007165

signal transduction

TAS

9169142

GO:0006897

endocytosis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

GO:0005768

endosome

IEA

GO:0016020

membrane

IEA

GO:0031901

early endosome membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADRB1	ADRB1R \| B1AR \| BETA1AR \| RHR	adrenergic, beta-1-, receptor	Beta-1-AR interacts with SH3p13. This interaction was modeled on a demonstrated interaction between human Beta-1-AR and rat SH3p13.	BIND	10535961
AES	AES-1 \| AES-2 \| ESP1 \| GRG \| GRG5 \| TLE5	amino-terminal enhancer of split	Two-hybrid	BioGRID	16169070
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Two-hybrid	BioGRID	16169070
C11orf68	BLES03 \| P5326	chromosome 11 open reading frame 68	Two-hybrid	BioGRID	16169070
C4orf17	DKFZp434G072	chromosome 4 open reading frame 17	Two-hybrid	BioGRID	16169070
CALCOCO1	Cocoa \| KIAA1536 \| PP13275 \| calphoglin	calcium binding and coiled-coil domain 1	Two-hybrid	BioGRID	16169070
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11894096
CRIP1	CRHP \| CRIP \| CRP1 \| FLJ40971	cysteine-rich protein 1 (intestinal)	Two-hybrid	BioGRID	16169070
DNM1	DNM	dynamin 1	Endophilin A3 interacts with Dynamin.	BIND	11894096
DNM1	DNM	dynamin 1	-	HPRD	9238017
DPPA4	2410091M23Rik \| FLJ10713	developmental pluripotency associated 4	Two-hybrid	BioGRID	16169070
DPYSL4	CRMP3 \| DRP-4 \| ULIP4	dihydropyrimidinase-like 4	Two-hybrid	BioGRID	16169070
EGFL6	DKFZp564P2063 \| MAEG \| W80	EGF-like-domain, multiple 6	Two-hybrid	BioGRID	16169070
EMD	EDMD \| LEMD5 \| STA	emerin	Two-hybrid	BioGRID	16169070
FAM173A	C16orf24 \| MGC2494	family with sequence similarity 173, member A	Two-hybrid	BioGRID	16169070
GABBR2	FLJ36928 \| GABABR2 \| GPR51 \| GPRC3B \| HG20 \| HRIHFB2099	gamma-aminobutyric acid (GABA) B receptor, 2	Two-hybrid	BioGRID	16169070
HTT	HD \| IT15	huntingtin	HD interacts with SH3GL3.	BIND	9809064
HTT	HD \| IT15	huntingtin	-	HPRD,BioGRID	9809064
IGSF2	CD101 \| V7	immunoglobulin superfamily, member 2	Two-hybrid	BioGRID	16169070
NDUFB9	B22 \| DKFZp566O173 \| FLJ22885 \| LYRM3 \| UQOR22	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	Two-hybrid	BioGRID	16169070
PDCD6IP	AIP1 \| Alix \| DRIP4 \| HP95 \| MGC17003	programmed cell death 6 interacting protein	-	HPRD	12034747
QTRT1	FP3235 \| TGT	queuine tRNA-ribosyltransferase 1	Two-hybrid	BioGRID	16169070
RER1	-	RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16169070
RPL35A	-	ribosomal protein L35a	Two-hybrid	BioGRID	16169070
SH3D19	EBP \| EVE1 \| Kryn \| MGC105136 \| MGC118910 \| MGC118911 \| MGC118912 \| MGC118913 \| SH3P19	SH3 domain containing 19	-	HPRD	14551139
SH3GL1	CNSA1 \| EEN \| MGC111371 \| SH3D2B \| SH3P8	SH3-domain GRB2-like 1	Two-hybrid	BioGRID	16169070
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	Endophilin A3 interacts with CIN85.	BIND	11894096
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	11894096
SNRPN	DKFZp686C0927 \| DKFZp686M12165 \| DKFZp761I1912 \| DKFZp762N022 \| FLJ33569 \| FLJ36996 \| FLJ39265 \| HCERN3 \| MGC29886 \| PWCR \| RT-LI \| SM-D \| SMN \| SNRNP-N \| SNURF-SNRPN	small nuclear ribonucleoprotein polypeptide N	Two-hybrid	BioGRID	16169070
TERF1	FLJ41416 \| PIN2 \| TRBF1 \| TRF \| TRF1 \| hTRF1-AS \| t-TRF1	telomeric repeat binding factor (NIMA-interacting) 1	Two-hybrid	BioGRID	16169070
TOE1	FLJ13949	target of EGR1, member 1 (nuclear)	Two-hybrid	BioGRID	16169070
WDR33	FLJ11294 \| WDC146	WD repeat domain 33	Two-hybrid	BioGRID	16169070

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ENDOCYTOSIS	183	132	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP	171	112	All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN	91	58	All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN	104	72	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	33	24	All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN	186	107	All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5	147	89	All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL	116	62	All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1	229	137	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
LE_EGR2_TARGETS_UP	108	75	All SZGR genes in this pathway
GERY_CEBP_TARGETS	126	90	All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D	79	62	All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP	244	165	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP	178	111	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP	148	96	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP	317	208	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP	461	298	All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP	430	288	All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12	317	177	All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP	166	105	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL	129	85	All SZGR genes in this pathway
LU_EZH2_TARGETS_UP	295	155	All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP	259	159	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	128	134	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-27	415	421	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	415	421	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-3p	34	40	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	34	40	m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-381	157	163	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.