Summary ?
DescriptionSH3-domain GRB2-like 3
Gene typeprotein-coding
Map location15q24
Pascal p-value2.666E-4
Sherlock p-value0.95
Fetal beta-0.225

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0594 

Section I. Genetics and epigenetics annotation


SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0008289lipid bindingIEA-
GO:0042802identical protein bindingIPI16115810 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)9169142 
GO:0007165signal transductionTAS9169142 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031901early endosome membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB1ADRB1R | B1AR | BETA1AR | RHRadrenergic, beta-1-, receptorBeta-1-AR interacts with SH3p13. This interaction was modeled on a demonstrated interaction between human Beta-1-AR and rat SH3p13.BIND10535961 
AESAES-1 | AES-2 | ESP1 | GRG | GRG5 | TLE5amino-terminal enhancer of splitTwo-hybridBioGRID16169070 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaTwo-hybridBioGRID16169070 
C11orf68BLES03 | P5326chromosome 11 open reading frame 68Two-hybridBioGRID16169070 
C4orf17DKFZp434G072chromosome 4 open reading frame 17Two-hybridBioGRID16169070 
CALCOCO1Cocoa | KIAA1536 | PP13275 | calphoglincalcium binding and coiled-coil domain 1Two-hybridBioGRID16169070 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID11894096 
CRIP1CRHP | CRIP | CRP1 | FLJ40971cysteine-rich protein 1 (intestinal)Two-hybridBioGRID16169070 
DNM1DNMdynamin 1Endophilin A3 interacts with Dynamin.BIND11894096 
DNM1DNMdynamin 1-HPRD9238017 
DPPA42410091M23Rik | FLJ10713developmental pluripotency associated 4Two-hybridBioGRID16169070 
DPYSL4CRMP3 | DRP-4 | ULIP4dihydropyrimidinase-like 4Two-hybridBioGRID16169070 
EGFL6DKFZp564P2063 | MAEG | W80EGF-like-domain, multiple 6Two-hybridBioGRID16169070 
EMDEDMD | LEMD5 | STAemerinTwo-hybridBioGRID16169070 
FAM173AC16orf24 | MGC2494family with sequence similarity 173, member ATwo-hybridBioGRID16169070 
GABBR2FLJ36928 | GABABR2 | GPR51 | GPRC3B | HG20 | HRIHFB2099gamma-aminobutyric acid (GABA) B receptor, 2Two-hybridBioGRID16169070 
HTTHD | IT15huntingtinHD interacts with SH3GL3.BIND9809064 
HTTHD | IT15huntingtin-HPRD,BioGRID9809064 
IGSF2CD101 | V7immunoglobulin superfamily, member 2Two-hybridBioGRID16169070 
NDUFB9B22 | DKFZp566O173 | FLJ22885 | LYRM3 | UQOR22NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDaTwo-hybridBioGRID16169070 
PDCD6IPAIP1 | Alix | DRIP4 | HP95 | MGC17003programmed cell death 6 interacting protein-HPRD12034747 
QTRT1FP3235 | TGTqueuine tRNA-ribosyltransferase 1Two-hybridBioGRID16169070 
RER1-RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)Two-hybridBioGRID16169070 
RPL35A-ribosomal protein L35aTwo-hybridBioGRID16169070 
SH3D19EBP | EVE1 | Kryn | MGC105136 | MGC118910 | MGC118911 | MGC118912 | MGC118913 | SH3P19SH3 domain containing 19-HPRD14551139 
SH3GL1CNSA1 | EEN | MGC111371 | SH3D2B | SH3P8SH3-domain GRB2-like 1Two-hybridBioGRID16169070 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Endophilin A3 interacts with CIN85.BIND11894096 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Affinity Capture-Western
Reconstituted Complex
SNRPNDKFZp686C0927 | DKFZp686M12165 | DKFZp761I1912 | DKFZp762N022 | FLJ33569 | FLJ36996 | FLJ39265 | HCERN3 | MGC29886 | PWCR | RT-LI | SM-D | SMN | SNRNP-N | SNURF-SNRPNsmall nuclear ribonucleoprotein polypeptide NTwo-hybridBioGRID16169070 
TERF1FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1telomeric repeat binding factor (NIMA-interacting) 1Two-hybridBioGRID16169070 
TOE1FLJ13949target of EGR1, member 1 (nuclear)Two-hybridBioGRID16169070 
WDR33FLJ11294 | WDC146WD repeat domain 33Two-hybridBioGRID16169070 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171112All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS DN 9158All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN 10472All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F DN 3324All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP 10875All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 7962All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP 166105All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 12985All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method