SZGR2

Summary ?

GeneID	648
Symbol	BMI1
Synonyms	FLVI2/BMI1\|PCGF4\|RNF51\|flvi-2/bmi-1
Description	BMI1 proto-oncogene, polycomb ring finger
Reference	MIM:164831\|HGNC:HGNC:1066\|Ensembl:ENSG00000168283\|HPRD:01277\|Vega:OTTHUMG00000017807
Gene type	protein-coding
Map location	10p11.23
Pascal p-value	0.941
Sherlock p-value	0.042
Fetal beta	1.311
eGene	Myers' cis & trans
Support	Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs7972594	chr12	11724913	BMI1	648		0.19		trans
rs10491979	chr12	11727969	BMI1	648		0.19		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PLA2R1	0.59	0.58
SLC22A6	0.57	0.48
FOXC2	0.56	0.54
ISLR	0.55	0.60
GJB2	0.55	0.57
C7	0.54	0.61
OGN	0.53	0.58
TMEM132C	0.53	0.66
BMP5	0.53	0.40
F13A1	0.53	0.64

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SNHG12	-0.26	-0.31
C6orf124	-0.24	-0.28
NEUROD2	-0.23	-0.24
FOXG1B	-0.23	-0.22
RPL37	-0.23	-0.36
C14orf23	-0.23	-0.30
AC005921.3	-0.22	-0.32
AC132872.1	-0.22	-0.28
AC073657.2	-0.22	-0.25
CLK1	-0.22	-0.23

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BMI1	MGC12685 \| PCGF4 \| RNF51	BMI1 polycomb ring finger oncogene	Reconstituted Complex	BioGRID	9858531
BMI1	MGC12685 \| PCGF4 \| RNF51	BMI1 polycomb ring finger oncogene	BMI1 forms a homodimer.	BIND	9858531
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
CBX4	NBP16 \| PC2 \| hPC2	chromobox homolog 4 (Pc class homolog, Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	9199346 \|12829790
CBX8	HPC3 \| PC3 \| RC1	chromobox homolog 8 (Pc class homolog, Drosophila)	-	HPRD	10825164
E2F6	E2F-6 \| MGC111545	E2F transcription factor 6	-	HPRD,BioGRID	11171983
IMMT	DKFZp779P1653 \| HMP \| MGC111146 \| P87 \| P87/89 \| P89 \| PIG4 \| PIG52	inner membrane protein, mitochondrial (mitofilin)	Two-hybrid	BioGRID	16169070
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	Two-hybrid	BioGRID	16169070
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
MAPKAPK3	3PK \| MAPKAP3	mitogen-activated protein kinase-activated protein kinase 3	3pK interacts with and phosphorylates Bmi1.	BIND	15563468
MLL	ALL-1 \| CXXC7 \| FLJ11783 \| HRX \| HTRX1 \| KMT2A \| MLL/GAS7 \| MLL1A \| TET1-MLL \| TRX1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	-	HPRD,BioGRID	12829790
PHC1	EDR1 \| HPH1 \| RAE28	polyhomeotic homolog 1 (Drosophila)	HPH1 interacts with Bmi1.	BIND	15563468
PHC1	EDR1 \| HPH1 \| RAE28	polyhomeotic homolog 1 (Drosophila)	-	HPRD,BioGRID	9121482
PHC1	EDR1 \| HPH1 \| RAE28	polyhomeotic homolog 1 (Drosophila)	-	HPRD	9009205
PHC2	EDR2 \| HPH2 \| MGC163502 \| PH2	polyhomeotic homolog 2 (Drosophila)	-	HPRD,BioGRID	9121482
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	Two-hybrid	BioGRID	16169070
RING1	RING1A \| RNF1	ring finger protein 1	RING1 interacts with BMI1.	BIND	9858531
RING1	RING1A \| RNF1	ring finger protein 1	-	HPRD,BioGRID	9199346 \|9858531
RNF2	BAP-1 \| BAP1 \| DING \| HIPI3 \| RING1B \| RING2	ring finger protein 2	Rnf2 interacts with Bmi1.	BIND	15563468
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	-	HPRD,BioGRID	12408802

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION	77	51	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1	40	26	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN	103	59	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE DN	13	6	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 2	30	23	All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11	63	45	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP	142	93	All SZGR 2.0 genes in this pathway
SMITH LIVER CANCER	45	27	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS DN	32	22	All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP	79	46	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP	48	34	All SZGR 2.0 genes in this pathway
PARK HSC MARKERS	44	31	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP	87	67	All SZGR 2.0 genes in this pathway
WANG IMMORTALIZED BY HOXA9 AND MEIS1 UP	31	24	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
GENTILE RESPONSE CLUSTER D3	61	39	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN	314	188	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
GAZIN EPIGENETIC SILENCING BY KRAS	26	16	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS	78	49	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN	72	47	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE	67	51	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE	81	66	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL	65	49	All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES UP	7	6	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA	43	27	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP	74	45	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
ZHAN LATE DIFFERENTIATION GENES UP	33	24	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 1	28	19	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION	130	87	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S	162	86	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D	280	158	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Gene Page: BMI1