Summary ?
GeneID6489
SymbolST8SIA1
SynonymsGD3S|SIAT8|SIAT8-A|SIAT8A|ST8SiaI
DescriptionST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1
ReferenceMIM:601123|HGNC:HGNC:10869|Ensembl:ENSG00000111728|HPRD:03078|Vega:OTTHUMG00000169098
Gene typeprotein-coding
Map location12p12.1-p11.2
Pascal p-value0.006
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
ExpressionMeta-analysis of gene expressionP value: 1.654 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HDAC70.850.88
CHTF180.790.68
SH3BP20.790.80
SCRIB0.790.77
LRP50.790.80
AC005005.30.780.76
SUV420H20.780.73
SBNO20.780.83
LEPRE10.780.70
MUTYH0.780.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACOT13-0.60-0.69
ITM2B-0.59-0.65
ACYP2-0.57-0.66
TPMT-0.55-0.62
FAM162A-0.55-0.64
HIGD1A-0.55-0.65
OMG-0.55-0.63
CLYBL-0.55-0.62
CISD1-0.55-0.64
C5orf53-0.55-0.59

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activityIEA-
GO:0016757transferase activity, transferring glycosyl groupsIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006486protein amino acid glycosylationIEA-
GO:0005975carbohydrate metabolic processTAS8195250 
GO:0008284positive regulation of cell proliferationIEA-
GO:0006688glycosphingolipid biosynthetic processTAS8195250 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneTAS8195250 
GO:0030173integral to Golgi membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES 2619All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS GLOBO SERIES 1412All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS GANGLIO SERIES 159All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 17582All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162116All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 9264All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN 4528All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR UP 1813All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN T LYMPHOCYTE DN 3729All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 9772All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN UP 3920All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240153All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 11573All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway