Gene Page: C12orf43
Summary ?
| GeneID | 64897 |
| Symbol | C12orf43 |
| Synonyms | - |
| Description | chromosome 12 open reading frame 43 |
| Reference | HGNC:HGNC:25719|Ensembl:ENSG00000157895|HPRD:07771| |
| Gene type | protein-coding |
| Map location | 12q24.31 |
| Pascal p-value | 0.012 |
| Sherlock p-value | 0.135 |
| Fetal beta | -0.501 |
| DMG | 1 (# studies) |
| eGene | Cerebellum Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg03531916 | 12 | 121454356 | C12orf43 | 5.54E-9 | -0.022 | 3.04E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10751722 | chr1 | 27543522 | C12orf43 | 64897 | 0.01 | trans | ||
| rs10211183 | chr2 | 60302291 | C12orf43 | 64897 | 0.07 | trans | ||
| rs3769467 | chr2 | 201205340 | C12orf43 | 64897 | 0.11 | trans | ||
| rs3769461 | chr2 | 201222657 | C12orf43 | 64897 | 0.11 | trans | ||
| rs2840033 | chr5 | 124609648 | C12orf43 | 64897 | 0.18 | trans | ||
| rs763641 | chr11 | 123846625 | C12orf43 | 64897 | 0 | trans | ||
| rs4598716 | chr12 | 19225582 | C12orf43 | 64897 | 0.12 | trans | ||
| rs7309022 | chr12 | 92666566 | C12orf43 | 64897 | 0.02 | trans | ||
| rs570278 | chr19 | 39632812 | C12orf43 | 64897 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |