Gene Page: TTC23
Summary ?
| GeneID | 64927 |
| Symbol | TTC23 |
| Synonyms | HCC-8 |
| Description | tetratricopeptide repeat domain 23 |
| Reference | HGNC:HGNC:25730|Ensembl:ENSG00000103852|HPRD:07777|Vega:OTTHUMG00000147344 |
| Gene type | protein-coding |
| Map location | 15q26.3 |
| Pascal p-value | 0.244 |
| Fetal beta | 0.36 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Hippocampus Hypothalamus Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs34567778 | 15 | 99642518 | TTC23 | ENSG00000103852.8 | 8.327E-7 | 0.03 | 148910 | gtex_brain_ba24 |
| rs34878632 | 15 | 99645262 | TTC23 | ENSG00000103852.8 | 8.136E-7 | 0.03 | 146166 | gtex_brain_ba24 |
| rs8037159 | 15 | 99660862 | TTC23 | ENSG00000103852.8 | 9.943E-7 | 0.03 | 130566 | gtex_brain_ba24 |
| rs7178124 | 15 | 99773270 | TTC23 | ENSG00000103852.8 | 8.389E-7 | 0.03 | 18158 | gtex_brain_ba24 |
| rs2084900 | 15 | 99774542 | TTC23 | ENSG00000103852.8 | 8.38E-7 | 0.03 | 16886 | gtex_brain_ba24 |
| rs55909409 | 15 | 99781204 | TTC23 | ENSG00000103852.8 | 1.369E-6 | 0.03 | 10224 | gtex_brain_ba24 |
| rs12591132 | 15 | 99784210 | TTC23 | ENSG00000103852.8 | 8.145E-7 | 0.03 | 7218 | gtex_brain_ba24 |
| rs8043311 | 15 | 99789742 | TTC23 | ENSG00000103852.8 | 8.132E-7 | 0.03 | 1686 | gtex_brain_ba24 |
| rs8025136 | 15 | 99789951 | TTC23 | ENSG00000103852.8 | 8.132E-7 | 0.03 | 1477 | gtex_brain_ba24 |
| rs62023767 | 15 | 99791392 | TTC23 | ENSG00000103852.8 | 8.111E-7 | 0.03 | 36 | gtex_brain_ba24 |
| rs8028374 | 15 | 99794174 | TTC23 | ENSG00000103852.8 | 5.645E-7 | 0.03 | -2746 | gtex_brain_ba24 |
| rs1567417 | 15 | 99794611 | TTC23 | ENSG00000103852.8 | 5.639E-7 | 0.03 | -3183 | gtex_brain_ba24 |
| rs5814930 | 15 | 99794742 | TTC23 | ENSG00000103852.8 | 5.634E-7 | 0.03 | -3314 | gtex_brain_ba24 |
| rs10152794 | 15 | 99800698 | TTC23 | ENSG00000103852.8 | 5.64E-7 | 0.03 | -9270 | gtex_brain_ba24 |
| rs7175165 | 15 | 99806661 | TTC23 | ENSG00000103852.8 | 1.213E-6 | 0.03 | -15233 | gtex_brain_ba24 |
| rs10152456 | 15 | 99810848 | TTC23 | ENSG00000103852.8 | 5.673E-7 | 0.03 | -19420 | gtex_brain_ba24 |
| rs8042439 | 15 | 99817442 | TTC23 | ENSG00000103852.8 | 7.594E-7 | 0.03 | -26014 | gtex_brain_ba24 |
| rs2902154 | 15 | 99818978 | TTC23 | ENSG00000103852.8 | 5.682E-7 | 0.03 | -27550 | gtex_brain_ba24 |
| rs1567418 | 15 | 99829531 | TTC23 | ENSG00000103852.8 | 5.669E-7 | 0.03 | -38103 | gtex_brain_ba24 |
| rs56341787 | 15 | 99830069 | TTC23 | ENSG00000103852.8 | 5.803E-7 | 0.03 | -38641 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 15Q26 AMPLICON | 22 | 19 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA CANCER | 83 | 52 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE MIDDLE | 98 | 56 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |