Gene Page: SLC6A2

Summary ?
GeneID6530
SymbolSLC6A2
SynonymsNAT1|NET|NET1|SLC6A5
Descriptionsolute carrier family 6 member 2
ReferenceMIM:163970|HGNC:HGNC:11048|Ensembl:ENSG00000103546|HPRD:01232|Vega:OTTHUMG00000133208
Gene typeprotein-coding
Map location16q12.2
Pascal p-value0.439
Fetal beta0.359
eGeneMyers' cis & trans
Meta
SupportNEUROTRANSMITTER METABOLISM

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16869851chr420690056SLC6A265300.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CMTM60.740.70
TMBIM60.730.58
CYP2U10.710.65
PTTG1IP0.700.53
AP000872.10.700.62
NXT20.700.46
TRAM10.690.63
ANO60.680.70
SEPT20.680.55
SLC35F50.670.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC098691.2-0.39-0.46
AL022328.1-0.35-0.35
AF347015.21-0.33-0.40
FXYD1-0.32-0.37
AC104794.1-0.32-0.30
AC018755.7-0.32-0.34
APOC1-0.30-0.29
S100A13-0.29-0.34
MYL3-0.29-0.34
AF347015.18-0.29-0.37

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005334norephinephrine:sodium symporter activityTASNeurotransmitter (GO term level: 10)2008212 
GO:0005328neurotransmitter:sodium symporter activityIEANeurotransmitter (GO term level: 9)-
GO:0005515protein bindingIPI11343649 
GO:0008504monoamine transmembrane transporter activityIDA16024787 
GO:0015293symporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)2008212 
GO:0006836neurotransmitter transportIEAneuron, Neurotransmitter (GO term level: 5)-
GO:0015844monoamine transportIDA16024787 
GO:0048265response to painIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS2008212 
GO:0005737cytoplasmIDA18029348 
GO:0005739mitochondrionIDA18029348 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneIEA-
GO:0005887integral to plasma membraneTAS2008212 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 8954All SZGR 2.0 genes in this pathway
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 1712All SZGR 2.0 genes in this pathway
REACTOME AMINE COMPOUND SLC TRANSPORTERS 2716All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN 172112All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
ROYLANCE BREAST CANCER 16Q COPY NUMBER DN 2619All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 11471All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 7447All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR UP 1813All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER 5729All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN 159105All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION D 6844All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 UP 6543All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway