Gene Page: SLC6A3

Summary ?
GeneID6531
SymbolSLC6A3
SynonymsDAT|DAT1|PKDYS
Descriptionsolute carrier family 6 member 3
ReferenceMIM:126455|HGNC:HGNC:11049|Ensembl:ENSG00000142319|HPRD:00543|Vega:OTTHUMG00000131016
Gene typeprotein-coding
Map location5p15.3
Pascal p-value0.876
Sherlock p-value0.925
DMG1 (# studies)
SupportDOPAMINE
NEUROTRANSMITTER METABOLISM

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3854 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2620513151444878SLC6A3-0.0210.29DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ARSB0.920.93
PTPN90.910.94
TSPAN140.900.91
DTX40.900.93
CDK5R10.900.92
PACS10.900.92
SARM10.900.93
SAP1300.890.92
DYRK20.890.94
GPRIN10.890.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
S100B-0.73-0.84
MT-CO2-0.73-0.86
C5orf53-0.73-0.78
AF347015.33-0.72-0.84
AF347015.31-0.72-0.84
FXYD1-0.72-0.83
AF347015.27-0.71-0.83
MT-CYB-0.69-0.81
AF347015.8-0.69-0.84
AC021016.1-0.69-0.81

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005330dopamine:sodium symporter activityIEANeurotransmitter, dopamine (GO term level: 10)-
GO:0005515protein bindingIPI11343649 
GO:0015293symporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0015872dopamine transportIEANeurotransmitter, dopamine (GO term level: 8)-
GO:0042053regulation of dopamine metabolic processIEAdopamine (GO term level: 9)-
GO:0042420dopamine catabolic processIEANeurotransmitter, dopamine (GO term level: 9)-
GO:0042416dopamine biosynthetic processIEANeurotransmitter, dopamine (GO term level: 9)-
GO:0007626locomotory behaviorIEA-
GO:0007608sensory perception of smellIEA-
GO:0007595lactationIEA-
GO:0015844monoamine transportIDA16024787 
GO:0021984adenohypophysis developmentIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0060134prepulse inhibitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS10823899 
GO:0005886plasma membraneIDA11343649 
GO:0005887integral to plasma membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PARKINSONS DISEASE 13378All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 8954All SZGR 2.0 genes in this pathway
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 1712All SZGR 2.0 genes in this pathway
REACTOME AMINE COMPOUND SLC TRANSPORTERS 2716All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 5P15 AMPLICON 2615All SZGR 2.0 genes in this pathway
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER 9460All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 12376All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 8255All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway