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| GeneID |
6531
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| Symbol |
SLC6A3
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| Synonyms |
DAT|DAT1
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| Description |
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 |
| See related |
HGNC:11049|MIM:126455|Ensembl:ENSG00000142319|HPRD:00543| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
5p15.3 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 2 | Link to SZGene | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 5 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.3854 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
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| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| ARSB | 0.92 | 0.93 | | |
| PTPN9 | 0.91 | 0.94 | | |
| TSPAN14 | 0.90 | 0.91 | | |
| DTX4 | 0.90 | 0.93 | | |
| CDK5R1 | 0.90 | 0.92 | | |
| PACS1 | 0.90 | 0.92 | | |
| SARM1 | 0.90 | 0.93 | | |
| SAP130 | 0.89 | 0.92 | | |
| DYRK2 | 0.89 | 0.94 | | |
| GPRIN1 | 0.89 | 0.91 | | |
Top 10 negatively co-expressed genes | | S100B | -0.73 | -0.84 | | |
| MT-CO2 | -0.73 | -0.86 | | |
| C5orf53 | -0.73 | -0.78 | | |
| AF347015.33 | -0.72 | -0.84 | | |
| AF347015.31 | -0.72 | -0.84 | | |
| FXYD1 | -0.72 | -0.83 | | |
| AF347015.27 | -0.71 | -0.83 | | |
| MT-CYB | -0.69 | -0.81 | | |
| AF347015.8 | -0.69 | -0.84 | | |
| AC021016.1 | -0.69 | -0.81 | | |
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| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005330 | dopamine:sodium symporter activity | IEA | Neurotransmitter, dopamine (GO term level: 10) | - |
| GO:0005515 | protein binding | IPI | | 11343649 |
| GO:0015293 | symporter activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0015872 | dopamine transport | IEA | Neurotransmitter, dopamine (GO term level: 8) | - |
| GO:0042053 | regulation of dopamine metabolic process | IEA | dopamine (GO term level: 9) | - |
| GO:0042420 | dopamine catabolic process | IEA | Neurotransmitter, dopamine (GO term level: 9) | - |
| GO:0042416 | dopamine biosynthetic process | IEA | Neurotransmitter, dopamine (GO term level: 9) | - |
| GO:0007626 | locomotory behavior | IEA | | - |
| GO:0007608 | sensory perception of smell | IEA | | - |
| GO:0007595 | lactation | IEA | | - |
| GO:0015844 | monoamine transport | IDA | | 16024787 |
| GO:0021984 | adenohypophysis development | IEA | | - |
| GO:0040018 | positive regulation of multicellular organism growth | IEA | | - |
| GO:0060134 | prepulse inhibition | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005737 | cytoplasm | TAS | | 10823899 |
| GO:0005886 | plasma membrane | IDA | | 11343649 |
| GO:0005887 | integral to plasma membrane | IEA | | - |
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