Summary ?
GeneID653361
SymbolNCF1
SynonymsNCF1A|NOXO2|SH3PXD1A|p47phox
Descriptionneutrophil cytosolic factor 1
ReferenceMIM:608512|HGNC:HGNC:7660|Ensembl:ENSG00000158517|Vega:OTTHUMG00000149965
Gene typeprotein-coding
Map location7q11.23
Pascal p-value0.009
Sherlock p-value0.585
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17013080chr1208862652NCF16533610.14trans
rs4844714chr1208874118NCF16533610.06trans
rs16827560chr2148370349NCF16533610.11trans
rs13076961chr3145745812NCF16533610.14trans
snp_a-18785830NCF16533610.03trans
rs16999761chr4107454800NCF16533610.06trans
rs10517578chr4154648151NCF16533610.17trans
rs17030417chr4154670812NCF16533610.07trans
rs11732581chr4154720237NCF16533610.11trans
rs10038062chr535220518NCF16533610.04trans
rs7731153chr535220864NCF16533610.04trans
rs10940060chr565712524NCF16533610.13trans
rs6862998chr5124365920NCF16533610.19trans
rs6862844chr5124365966NCF16533610.19trans
rs17116175chr5153844992NCF16533610.18trans
rs7754123chr6132667231NCF16533610.04trans
rs1830326chr756266838NCF16533610.13trans
rs6959168chr756288292NCF16533610.03trans
rs1357741chr756291169NCF16533610.03trans
rs11489759chr756393851NCF16533610.06trans
rs7807249chr7131615735NCF16533610trans
rs10828685chr1024975616NCF16533610.02trans
rs17111391chr1097950485NCF16533610.01trans
rs231348chr112673680NCF16533610.14trans
rs767957chr12119038434NCF16533610.01trans
rs17076272chr1322726361NCF16533610.04trans
rs17076274chr1322726381NCF16533610.04trans
rs4814967chr2020209446NCF16533610.03trans
rs16981724chr2020210644NCF16533610.03trans
rs6114613chr2024277074NCF16533610.19trans
rs6106843chr2024288460NCF16533610.19trans
rs16993265chr2245396341NCF16533610.11trans
rs16979494chrX14301660NCF16533610.13trans
rs5955544chrX19246404NCF16533610.12trans
rs6527909chrX19265358NCF16533610.02trans
rs16982879chrX92924110NCF16533610.04trans
rs5908820chrX142941845NCF16533610.04trans
rs7879274chrX145592957NCF16533610.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, betaFar WesternBioGRID11027608 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptideTwo-hybridBioGRID11485312 
CYBAp22-PHOXcytochrome b-245, alpha polypeptideReconstituted ComplexBioGRID7938008 
IL4RCD124 | IL4RAinterleukin 4 receptorin vivoBioGRID10369419 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Reconstituted ComplexBioGRID8766817 
MSN-moesinAffinity Capture-Western
Reconstituted Complex
BioGRID11716484 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Reconstituted ComplexBioGRID7938008 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2Co-crystal Structure
Far Western
Protein-peptide
Reconstituted Complex
BioGRID7938008 |10486263 
|11733522 |11796733 
|12169629 
NCF4MGC3810 | NCF | P40PHOX | SH3PXD4neutrophil cytosolic factor 4, 40kDaReconstituted Complex
Two-hybrid
BioGRID9083043 |11258927 
|11796733 
PRKCBMGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2protein kinase C, betaAffinity Capture-WesternBioGRID11120743 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptideBiochemical ActivityBioGRID9914162 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-Western
Reconstituted Complex
BioGRID12618429 
SYN1SYN1a | SYN1b | SYNIsynapsin Iin vivoBioGRID10899172 
SYTL1FLJ14996 | JFC1 | SLP1synaptotagmin-like 1Reconstituted ComplexBioGRID11278853 
TRAF4CART1 | MLN62 | RNF83TNF receptor-associated factor 4Affinity Capture-WesternBioGRID12023963 
TRIM9KIAA0282 | RNF91 | SPRINGtripartite motif-containing 9Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
WILENSKY RESPONSE TO DARAPLADIB 2920All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION DN 137All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING UP 4124All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION UP 4126All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway