Gene Page: SLC13A1

Summary ?
GeneID6561
SymbolSLC13A1
SynonymsNAS1|NaSi-1
Descriptionsolute carrier family 13 member 1
ReferenceMIM:606193|HGNC:HGNC:10916|Ensembl:ENSG00000081800|HPRD:08394|Vega:OTTHUMG00000157087
Gene typeprotein-coding
Map location7q31.32
Pascal p-value0.59
eGeneMeta
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
DNM:McCarthy_2014Whole Exome Sequencing analysisWhole exome sequencing of 57 trios with sporadic or familial schizophrenia.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
SLC13A1chr7122765663AGNM_022444p.P400Psynonymous SNVSchizophreniaDNM:McCarthy_2014
SLC13A1chr7122787322CTNM_022444p.235V>MmissenseSchizophreniaDNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CPSF70.950.95
SF3A10.950.95
RNF2140.950.95
RPRD20.940.96
SART30.940.95
SF10.940.95
DHX80.940.94
DHX380.940.93
LSM14B0.930.93
RNASEN0.930.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.80-0.88
MT-CO2-0.78-0.86
HIGD1B-0.77-0.86
IFI27-0.77-0.84
AF347015.21-0.75-0.90
FXYD1-0.75-0.83
MT-CYB-0.74-0.82
AF347015.27-0.74-0.83
AF347015.33-0.73-0.80
AF347015.8-0.73-0.83

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 8954All SZGR 2.0 genes in this pathway
REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 116All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
TUOMISTO TUMOR SUPPRESSION BY COL13A1 DN 1711All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway