Gene Page: BMPR1A

Summary ?
GeneID657
SymbolBMPR1A
Synonyms10q23del|ACVRLK3|ALK3|CD292|SKR5
Descriptionbone morphogenetic protein receptor type 1A
ReferenceMIM:601299|HGNC:HGNC:1076|HPRD:03192|
Gene typeprotein-coding
Map location10q22.3
Pascal p-value0.951
Sherlock p-value0.026
Fetal beta1.659
eGeneCerebellum
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF2590.950.96
MKRN10.950.95
DDX230.950.95
UBE2R20.940.95
NIPSNAP10.940.94
SSRP10.940.95
GPN10.940.93
UCK20.940.95
EDC30.940.94
PPM1G0.930.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.80-0.92
MT-CO2-0.78-0.91
AF347015.27-0.78-0.91
AF347015.33-0.77-0.89
MT-CYB-0.75-0.89
FXYD1-0.75-0.88
AF347015.8-0.75-0.90
HLA-F-0.74-0.79
C5orf53-0.74-0.76
AIFM3-0.74-0.79

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP2BMP2Abone morphogenetic protein 2Co-crystal Structure
Reconstituted Complex		BioGRID10692589 |10712517 
|10880444 |11263668 
BMP2BMP2Abone morphogenetic protein 2-HPRD10692589 |10881198 
|11263668|11263668 
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4-HPRD8702914 |11241215 
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4Reconstituted ComplexBioGRID8006002 
BMP6VGR | VGR1bone morphogenetic protein 6-HPRD,BioGRID10504300 |11401330 
BMP7OP-1bone morphogenetic protein 7Reconstituted ComplexBioGRID8006002 
BMP7OP-1bone morphogenetic protein 7-HPRD7791754 |8605097 
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IA-HPRD,BioGRID10712517 
BMPR1BALK-6 | ALK6 | CDw293bone morphogenetic protein receptor, type IB-HPRD,BioGRID10712517 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)-HPRD,BioGRID10712517 
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDaTwo-hybridBioGRID9663660 
FKBP1BFKBP12.6 | FKBP1L | OTK4 | PKBP1L | PPIaseFK506 binding protein 1B, 12.6 kDaTwo-hybridBioGRID15351706 
GDF5BMP14 | CDMP1 | LAP4 | SYNS2growth differentiation factor 5-HPRD,BioGRID9525338 |11282024 
GDF6BMP13 | CDMP2 | KFS | KFSL | MGC158100 | MGC158101 | SGM1growth differentiation factor 6Reconstituted ComplexBioGRID9525338 
GDF9-growth differentiation factor 9-HPRD10712517 |12135884 
HOXC8HOX3 | HOX3Ahomeobox C8-HPRD11139569 
MAP3K7IP13'-Tab1 | MGC57664 | TAB1mitogen-activated protein kinase kinase kinase 7 interacting protein 1-HPRD9663660 
SF3B4MGC10828 | SAP49 | SF3b49splicing factor 3b, subunit 4, 49kDa-HPRD,BioGRID15351706 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1-HPRD11438941 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7Affinity Capture-WesternBioGRID15148321 
TGFBRAP1TRAP-1 | TRAP1transforming growth factor, beta receptor associated protein 1-HPRD11278302 
ZMYND11BRAM1 | BS69 | MGC111056 | RP11-486H9.1zinc finger, MYND domain containing 11Affinity Capture-Western
Two-hybrid		BioGRID9663660 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY 3729All SZGR 2.0 genes in this pathway
PID BMP PATHWAY 4231All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP 2315All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276165All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 13983All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341197All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 8871All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK 8862All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 5132All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293160All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D4 5537All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 9175All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260174All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway