Summary ?
GeneID6582
SymbolSLC22A2
SynonymsOCT2
Descriptionsolute carrier family 22 member 2
ReferenceMIM:602608|HGNC:HGNC:10966|Ensembl:ENSG00000112499|HPRD:04008|Vega:OTTHUMG00000015950
Gene typeprotein-coding
Map location6q25.3
Pascal p-value0.066
Fetal beta-0.05
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg062362766160680078SLC22A24.024E-40.3830.044DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CALM30.900.91
ARF30.880.91
STX1A0.860.88
PTPRR0.860.89
MOAP10.860.87
SPRYD30.860.90
OXCT10.850.85
HPCAL40.850.86
AC073610.60.840.87
NAP1L50.830.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SMTN-0.42-0.42
HYAL2-0.42-0.42
IMPA2-0.40-0.44
IRF7-0.40-0.50
BCL7C-0.39-0.45
FAM59B-0.39-0.36
GRTP1-0.39-0.39
SH2D2A-0.39-0.40
SEMA4B-0.39-0.35
RAB13-0.38-0.46

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME ABACAVIR TRANSPORT AND METABOLISM 109All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RELEASE CYCLE 3430All SZGR 2.0 genes in this pathway
REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 1010All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 8954All SZGR 2.0 genes in this pathway
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 1712All SZGR 2.0 genes in this pathway
REACTOME AMINE COMPOUND SLC TRANSPORTERS 2716All SZGR 2.0 genes in this pathway
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT 139All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 8258All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION 4534All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
SU KIDNEY 158All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS DN 187109All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 6347All SZGR 2.0 genes in this pathway