Summary ?
GeneID6588
SymbolSLN
Synonyms-
Descriptionsarcolipin
ReferenceMIM:602203|HGNC:HGNC:11089|Ensembl:ENSG00000170290|HPRD:03729|
Gene typeprotein-coding
Map location11q22.3
Pascal p-value0.241
Fetal beta1.341
eGeneCerebellar Hemisphere
Cerebellum
Nucleus accumbens basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4526604chr142182143SLN65880.06trans
rs10158440chr1157672303SLN65880.19trans
rs7662675chr42413016SLN65880.1trans
rs4974710chr42414667SLN65880.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SNRPC0.920.90
H2AFZ0.910.89
BAT40.900.89
PMF10.890.88
BOD10.890.88
PHB20.880.93
DDX390.880.85
ABT10.880.89
RANBP10.880.85
APEX10.880.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.33-0.67-0.80
MT-CYB-0.67-0.81
AF347015.26-0.67-0.83
AF347015.15-0.66-0.81
AF347015.27-0.66-0.79
AF347015.8-0.66-0.80
MT-CO2-0.66-0.77
AF347015.31-0.65-0.76
AF347015.2-0.64-0.78
APOL1-0.62-0.71

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingISS-
GO:0030234enzyme regulator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006810transportTAS9367679 
GO:0051924regulation of calcium ion transportISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneTAS9367679 
GO:0033017sarcoplasmic reticulum membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 14699All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F 5432All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 5129All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
YAMANAKA GLIOBLASTOMA SURVIVAL UP 117All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280158All SZGR 2.0 genes in this pathway