Gene Page: SMARCA2

Summary
GeneID  6595
Symbol  SMARCA2
Synonyms  BAF190|BRM|FLJ36757|MGC74511|SNF2|SNF2L2|SNF2LA|SWI2|Sth1p|hBRM|hSNF2a
Description  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
See related  HGNC:11098|MIM:600014|Ensembl:ENSG00000080503|HPRD:02483|
Locus tag  -
Gene type  protein-coding
Map location  9p22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RPL300.940.84
RPL230.930.87
RPS80.930.88
HAUS10.930.88
RPL6P100.930.89
RPL35A0.930.85
TUT10.920.87
RPS16P10.920.81
RPL50.910.90
RPS25P80.910.84
Top 10 negatively co-expressed genes
HLA-F-0.59-0.72
ATP10A-0.59-0.74
PTH1R-0.58-0.71
TINAGL1-0.58-0.76
FBXO2-0.57-0.66
AIFM3-0.57-0.72
ALDOC-0.57-0.69
TNFSF12-0.56-0.61
AF347015.27-0.56-0.78
SLC6A12-0.56-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingIEA-
GO:0003713transcription coactivator activityTAS8223438 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI8895581 |12200431 |12437990 
|14701856 |15696166 
|16341228 
GO:0005524ATP bindingIEA-
GO:0004386helicase activityTAS8223438 
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS8223438 
GO:0006350transcriptionIEA-
GO:0008285negative regulation of cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmTAS8670841 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTL6AACTL6 | Arp4 | BAF53A | INO80K | MGC5382actin-like 6A-HPRD,BioGRID12437990 
ACTL6BACTL6 | BAF53Bactin-like 6B-HPRD,BioGRID12437990 
ARID1AB120 | BAF250 | BAF250a | BM029 | C1orf4 | P270 | SMARCF1AT rich interactive domain 1A (SWI-like)Co-purificationBioGRID8895581 
ARID1B6A3-5 | BAF250b | BRIGHT | DAN15 | ELD/OSA1 | KIAA1235 | p250RAT rich interactive domain 1B (SWI1-like)-HPRD,BioGRID12200431 
BAZ1BWBSCR10 | WBSCR9 | WSTFbromodomain adjacent to zinc finger domain, 1B-HPRD12837248 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-WesternBioGRID15034933 
CCNE1CCNEcyclin E1Affinity Capture-WesternBioGRID9891079 
CDK8K35 | MGC126074 | MGC126075cyclin-dependent kinase 8Co-fractionationBioGRID9710619 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), betaAffinity Capture-Western
Reconstituted Complex		BioGRID10619021 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID9099865 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Co-purificationBioGRID11238380 
HDAC2RPD3 | YAF1histone deacetylase 2Co-purificationBioGRID11238380 
MECP2AUTSX3 | DKFZp686A24160 | MRX16 | MRX79 | MRXS13 | MRXSL | PPMX | RTS | RTTmethyl CpG binding protein 2 (Rett syndrome)MeCP2 interacts with Brm.BIND15696166 
MYBCmyb | c-myb | c-myb_CDS | efgv-myb myeloblastosis viral oncogene homolog (avian)Reconstituted ComplexBioGRID10619021 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID8223438 
PHBPHB1prohibitinProhibitin interacts with Brm.BIND12065415 
-HPRD,BioGRID12065415 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD,BioGRID9710619 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Co-purificationBioGRID11238380 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)Co-fractionationBioGRID11839798 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Co-purification
Reconstituted Complex		BioGRID11238380 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Co-purificationBioGRID8895581 |11238380 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Co-purificationBioGRID8895581 |11238380 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Co-purificationBioGRID8895581 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1Co-purificationBioGRID8895581 
SS18MGC116875 | SSXT | SYT | SYT-SSX1 | SYT-SSX2synovial sarcoma translocation, chromosome 18-HPRD,BioGRID10072425 |11734557 
|14603256 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
PYEON_HPV_POSITIVE_TUMORS_UP 9847All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_DN 5234All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
SCIBETTA_KDM5B_TARGETS_DN 8155All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN 11671All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN 2915All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q 11671All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_UP 2820All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR 6233All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX1_UP 1510All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN 3222All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
LU_IL4_SIGNALING 9456All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
MEDINA_SMARCA4_TARGETS 4429All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_DN 5132All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP 166105All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN 207139All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1015956011Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-128463469m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1445956011Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-197727791A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-3201231291Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-376549555m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-4218068121Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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