Gene Page: BNIP1

Summary ?
GeneID662
SymbolBNIP1
SynonymsNIP1|SEC20|TRG-8
DescriptionBCL2/adenovirus E1B 19kDa interacting protein 1
ReferenceMIM:603291|HGNC:HGNC:1082|Ensembl:ENSG00000113734|HPRD:04480|Vega:OTTHUMG00000130521
Gene typeprotein-coding
Map location5q35.1
Pascal p-value0.002
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.0276 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17703470chr5171812351BNIP16620.14cis
rs13356223chr5171821670BNIP16620.14cis
rs13436547chr5171840724BNIP16620.2cis
rs177298415172472573BNIP1ENSG00000113734.131.178E-60.02-98872gtex_brain_ba24
rs1411781595172475940BNIP1ENSG00000113734.131.069E-60.02-95505gtex_brain_ba24
rs728141675172478593BNIP1ENSG00000113734.131.064E-60.02-92852gtex_brain_ba24
rs3752923385172482903BNIP1ENSG00000113734.131.028E-60.02-88542gtex_brain_ba24
rs728141785172486739BNIP1ENSG00000113734.131.073E-60.02-84706gtex_brain_ba24
rs728141795172489416BNIP1ENSG00000113734.131.073E-60.02-82029gtex_brain_ba24
rs580660265172494772BNIP1ENSG00000113734.131.073E-60.02-76673gtex_brain_ba24
rs360011735172500586BNIP1ENSG00000113734.131.073E-60.02-70859gtex_brain_ba24
rs1455439535172509306BNIP1ENSG00000113734.131.073E-60.02-62139gtex_brain_ba24
rs728161105172509839BNIP1ENSG00000113734.131.073E-60.02-61606gtex_brain_ba24
rs728161125172511550BNIP1ENSG00000113734.131.073E-60.02-59895gtex_brain_ba24
rs1490075715172512513BNIP1ENSG00000113734.131.073E-60.02-58932gtex_brain_ba24
rs728161155172515179BNIP1ENSG00000113734.131.073E-60.02-56266gtex_brain_ba24
rs728161175172516765BNIP1ENSG00000113734.131.073E-60.02-54680gtex_brain_ba24
rs728161195172519608BNIP1ENSG00000113734.131.073E-60.02-51837gtex_brain_ba24
rs604180955172522096BNIP1ENSG00000113734.131.073E-60.02-49349gtex_brain_ba24
rs728161225172524035BNIP1ENSG00000113734.131.073E-60.02-47410gtex_brain_ba24
rs728161245172524537BNIP1ENSG00000113734.131.073E-60.02-46908gtex_brain_ba24
rs728161265172524845BNIP1ENSG00000113734.131.073E-60.02-46600gtex_brain_ba24
rs578585575172531348BNIP1ENSG00000113734.131.073E-60.02-40097gtex_brain_ba24
rs176626395172534347BNIP1ENSG00000113734.131.073E-60.02-37098gtex_brain_ba24
rs1123567295172544816BNIP1ENSG00000113734.131.612E-60.02-26629gtex_brain_ba24
rs1381141445172547600BNIP1ENSG00000113734.131.073E-60.02-23845gtex_brain_ba24
rs728161425172549449BNIP1ENSG00000113734.131.073E-60.02-21996gtex_brain_ba24
rs728161465172552315BNIP1ENSG00000113734.131.073E-60.02-19130gtex_brain_ba24
rs728161475172552330BNIP1ENSG00000113734.131.073E-60.02-19115gtex_brain_ba24
rs1120247515172557038BNIP1ENSG00000113734.131.073E-60.02-14407gtex_brain_ba24
rs353872095172560793BNIP1ENSG00000113734.131.073E-60.02-10652gtex_brain_ba24
rs177304515172566698BNIP1ENSG00000113734.131.073E-60.02-4747gtex_brain_ba24
rs728161555172569032BNIP1ENSG00000113734.131.073E-60.02-2413gtex_brain_ba24
rs57450985172570687BNIP1ENSG00000113734.131.073E-60.02-758gtex_brain_ba24
rs57451105172572954BNIP1ENSG00000113734.131.073E-60.021509gtex_brain_ba24
rs57451145172574252BNIP1ENSG00000113734.131.081E-60.022807gtex_brain_ba24
rs57451165172575703BNIP1ENSG00000113734.131.073E-60.024258gtex_brain_ba24
rs57451185172576100BNIP1ENSG00000113734.131.073E-60.024655gtex_brain_ba24
rs57451205172576255BNIP1ENSG00000113734.131.073E-60.024810gtex_brain_ba24
rs57451275172577864BNIP1ENSG00000113734.131.073E-60.026419gtex_brain_ba24
rs57451355172580933BNIP1ENSG00000113734.131.073E-60.029488gtex_brain_ba24
rs3978437115172585210BNIP1ENSG00000113734.131.073E-60.0213765gtex_brain_ba24
rs85435172591337BNIP1ENSG00000113734.131.073E-60.0219892gtex_brain_ba24
rs728161685172595024BNIP1ENSG00000113734.131.073E-60.0223579gtex_brain_ba24
rs728161715172595998BNIP1ENSG00000113734.131.072E-60.0224553gtex_brain_ba24
rs177298415172472573BNIP1ENSG00000113734.132.152E-60.01-98872gtex_brain_putamen_basal
rs1411781595172475940BNIP1ENSG00000113734.137.17E-70.01-95505gtex_brain_putamen_basal
rs728141675172478593BNIP1ENSG00000113734.137.194E-70.01-92852gtex_brain_putamen_basal
rs3752923385172482903BNIP1ENSG00000113734.137.285E-70.01-88542gtex_brain_putamen_basal
rs728141785172486739BNIP1ENSG00000113734.137.2E-70.01-84706gtex_brain_putamen_basal
rs728141795172489416BNIP1ENSG00000113734.137.2E-70.01-82029gtex_brain_putamen_basal
rs1124270775172490001BNIP1ENSG00000113734.131.564E-70.01-81444gtex_brain_putamen_basal
rs580660265172494772BNIP1ENSG00000113734.137.2E-70.01-76673gtex_brain_putamen_basal
rs360011735172500586BNIP1ENSG00000113734.137.2E-70.01-70859gtex_brain_putamen_basal
rs1455439535172509306BNIP1ENSG00000113734.137.2E-70.01-62139gtex_brain_putamen_basal
rs728161105172509839BNIP1ENSG00000113734.137.2E-70.01-61606gtex_brain_putamen_basal
rs728161125172511550BNIP1ENSG00000113734.137.2E-70.01-59895gtex_brain_putamen_basal
rs1490075715172512513BNIP1ENSG00000113734.137.2E-70.01-58932gtex_brain_putamen_basal
rs728161155172515179BNIP1ENSG00000113734.137.2E-70.01-56266gtex_brain_putamen_basal
rs728161175172516765BNIP1ENSG00000113734.137.2E-70.01-54680gtex_brain_putamen_basal
rs728161195172519608BNIP1ENSG00000113734.136.945E-70.01-51837gtex_brain_putamen_basal
rs604180955172522096BNIP1ENSG00000113734.137.2E-70.01-49349gtex_brain_putamen_basal
rs728161225172524035BNIP1ENSG00000113734.137.2E-70.01-47410gtex_brain_putamen_basal
rs728161245172524537BNIP1ENSG00000113734.137.2E-70.01-46908gtex_brain_putamen_basal
rs728161265172524845BNIP1ENSG00000113734.137.2E-70.01-46600gtex_brain_putamen_basal
rs578585575172531348BNIP1ENSG00000113734.137.251E-70.01-40097gtex_brain_putamen_basal
rs176626395172534347BNIP1ENSG00000113734.137.251E-70.01-37098gtex_brain_putamen_basal
rs1123567295172544816BNIP1ENSG00000113734.132.063E-60.01-26629gtex_brain_putamen_basal
rs1381141445172547600BNIP1ENSG00000113734.137.251E-70.01-23845gtex_brain_putamen_basal
rs728161425172549449BNIP1ENSG00000113734.137.251E-70.01-21996gtex_brain_putamen_basal
rs728161465172552315BNIP1ENSG00000113734.137.251E-70.01-19130gtex_brain_putamen_basal
rs728161475172552330BNIP1ENSG00000113734.137.251E-70.01-19115gtex_brain_putamen_basal
rs1120247515172557038BNIP1ENSG00000113734.137.251E-70.01-14407gtex_brain_putamen_basal
rs353872095172560793BNIP1ENSG00000113734.137.251E-70.01-10652gtex_brain_putamen_basal
rs177304515172566698BNIP1ENSG00000113734.137.251E-70.01-4747gtex_brain_putamen_basal
rs728161555172569032BNIP1ENSG00000113734.137.251E-70.01-2413gtex_brain_putamen_basal
rs57450985172570687BNIP1ENSG00000113734.137.251E-70.01-758gtex_brain_putamen_basal
rs57451105172572954BNIP1ENSG00000113734.137.251E-70.011509gtex_brain_putamen_basal
rs57451145172574252BNIP1ENSG00000113734.135.867E-70.012807gtex_brain_putamen_basal
rs57451165172575703BNIP1ENSG00000113734.137.251E-70.014258gtex_brain_putamen_basal
rs57451185172576100BNIP1ENSG00000113734.137.251E-70.014655gtex_brain_putamen_basal
rs57451205172576255BNIP1ENSG00000113734.137.251E-70.014810gtex_brain_putamen_basal
rs57451275172577864BNIP1ENSG00000113734.137.251E-70.016419gtex_brain_putamen_basal
rs57451355172580933BNIP1ENSG00000113734.137.251E-70.019488gtex_brain_putamen_basal
rs85435172591337BNIP1ENSG00000113734.137.251E-70.0119892gtex_brain_putamen_basal
rs728161685172595024BNIP1ENSG00000113734.137.251E-70.0123579gtex_brain_putamen_basal
rs728161715172595998BNIP1ENSG00000113734.137.269E-70.0124553gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CDKN1C0.800.82
NAGLU0.740.72
CDC42EP20.740.76
C22orf90.720.73
RGS190.710.62
TESK10.700.69
CHST20.690.63
SLC25A100.690.63
NR2F60.680.64
MVK0.680.67
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.39-0.39
AF347015.21-0.39-0.41
MT-ATP8-0.38-0.43
AF347015.8-0.38-0.39
AF347015.27-0.38-0.37
MT-CO2-0.37-0.37
AF347015.2-0.35-0.36
AF347015.33-0.35-0.34
AF347015.15-0.34-0.36
MT-CYB-0.34-0.36

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI7954800 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006917induction of apoptosisIMP15272311 
GO:0007029endoplasmic reticulum organizationIMP15272311 
GO:0006916anti-apoptosisTAS7954800 
GO:0006915apoptosisIDA7954800 
GO:0016192vesicle-mediated transportIEA-
GO:0016320endoplasmic reticulum membrane fusionIMP15272311 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031201SNARE complexIDAneuron, Synap (GO term level: 6)15272311 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005635nuclear envelopeIDA7954800 
GO:0005737cytoplasmIDA7954800 
GO:0005783endoplasmic reticulumIDA15272311 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0030176integral to endoplasmic reticulum membraneTAS15272311 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT 3825All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA SIZE DN 148All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway