Gene Page: SNRNP70

Summary ?
GeneID6625
SymbolSNRNP70
SynonymsRNPU1Z|RPU1|SNRP70|Snp1|U1-70K|U170K|U1AP|U1RNP
Descriptionsmall nuclear ribonucleoprotein U1 subunit 70
ReferenceMIM:180740|HGNC:HGNC:11150|Ensembl:ENSG00000104852|HPRD:01617|Vega:OTTHUMG00000183344
Gene typeprotein-coding
Map location19q13.3
Pascal p-value0.007
Sherlock p-value0.095
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407SNRNP7066250trans
rs3845734chr2171125572SNRNP7066250.16trans
rs4114866chr66257660SNRNP7066250.12trans
rs3851513chr66274160SNRNP7066250.09trans
rs16955618chr1529937543SNRNP7066254.14E-4trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
COQ40.870.86
MOSPD30.840.84
ACD0.820.83
TADA3L0.820.81
ADCK40.810.82
MRPL430.810.81
UNC1190.810.82
VPS280.810.82
LRRC240.810.81
AP4M10.810.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.59-0.64
MT-CYB-0.58-0.65
AF347015.27-0.58-0.64
AF347015.31-0.58-0.63
AF347015.8-0.57-0.63
AF347015.15-0.55-0.63
AF347015.2-0.55-0.63
AF347015.33-0.55-0.59
AF347015.26-0.53-0.62
GBP2-0.50-0.54

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CRPMGC149895 | MGC88244 | PTX1C-reactive protein, pentraxin-related-HPRD,BioGRID2477447 
CTDP1CCFDN | FCP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1-HPRD12560496 
DDX17DKFZp761H2016 | P72 | RH70DEAD (Asp-Glu-Ala-Asp) box polypeptide 17-HPRD,BioGRID12193588 
FUSIP1FUSIP2 | NSSR | SFRS13 | SRp38 | SRrp40 | TASR | TASR1 | TASR2FUS interacting protein (serine/arginine-rich) 1Dephosphorylated SRp38 interacts with U1-70KBIND14765198 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-MSBioGRID17353931 
HNRNPA2B1DKFZp779B0244 | FLJ22720 | HNRNPA2 | HNRNPB1 | HNRPA2 | HNRPA2B1 | HNRPB1 | RNPA2 | SNRPB1heterogeneous nuclear ribonucleoprotein A2/B1-HPRD1833625 
NUDT21CFIM25 | CPSF5 | DKFZp686H1588nudix (nucleoside diphosphate linked moiety X)-type motif 21Reconstituted ComplexBioGRID14561889 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
SFRS1ASF | MGC5228 | SF2 | SF2p33 | SRp30asplicing factor, arginine/serine-rich 1-HPRD,BioGRID9799243 
SFRS11DKFZp686M13204 | dJ677H15.2 | p54splicing factor, arginine/serine-rich 11-HPRD8816452 
SFRS2PR264 | SC-35 | SC35 | SFRS2A | SRp30bsplicing factor, arginine/serine-rich 2-HPRD8261509 
SFRS2IPCASP11 | SIP1 | SRRP129splicing factor, arginine/serine-rich 2, interacting protein-HPRD9447963 
SIP1GEMIN2 | SIP1-deltasurvival of motor neuron protein interacting protein 1-HPRD9447963 
SNRPCFLJ20302small nuclear ribonucleoprotein polypeptide C-HPRD,BioGRID9826776 
SRPK1SFRSK1SFRS protein kinase 1Affinity Capture-Western
Biochemical Activity		BioGRID9472028 |12417631 
SRPK2FLJ36101 | SFRSK2SFRS protein kinase 2Biochemical ActivityBioGRID9472028 
ZRANB2DKFZp686J1831 | DKFZp686N09117 | FLJ41119 | ZIS | ZIS1 | ZIS2 | ZNF265zinc finger, RAN-binding domain containing 2-HPRD,BioGRID11448987 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SPLICEOSOME 12872All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 14077All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 16186All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING 11158All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID UP 2518All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 DN 107All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
LIN APC TARGETS 7755All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR 4330All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP 5225All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209137All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 7253All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 14081All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 11868All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway