Gene Page: SOX2

Summary
GeneID  6657
Symbol  SOX2
Synonyms  ANOP3|MCOPS3|MGC2413
Description  SRY (sex determining region Y)-box 2
See related  HGNC:11195|MIM:184429|Ensembl:ENSG00000181449|HPRD:08921|
Locus tag  -
Gene type  protein-coding
Map location  3q26.3-q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.374 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ENO10.750.73
HIBADH0.730.74
CD590.730.75
BTN3A30.730.71
CTSF0.720.74
TECR0.710.76
ATPAF10.710.75
NR1H20.710.79
SDHD0.700.72
ANXA70.700.73
Top 10 negatively co-expressed genes
ANKRD12-0.45-0.46
RTF1-0.45-0.45
CCAR1-0.44-0.49
AC004017.1-0.44-0.38
FNBP1L-0.44-0.35
ZNF551-0.44-0.38
PHF14-0.44-0.46
RBMX2-0.43-0.48
KIAA1949-0.43-0.35
AC109829.1-0.43-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS7849401 
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001708cell fate specificationIEA-
GO:0006355regulation of transcription, DNA-dependentNAS7849401 
GO:0006350transcriptionIEA-
GO:0006325establishment or maintenance of chromatin architectureNAS7849401 
GO:0050973detection of mechanical stimulus involved in equilibrioceptionIEA-
GO:0042472inner ear morphogenesisIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0050910detection of mechanical stimulus involved in sensory perception of soundIEA-
GO:0046148pigment biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS7849401 
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PAX6AN | AN2 | D11S812E | MGC17209 | MGDA | WAGRpaired box 6-HPRD,BioGRID11358870 |12710953 
|12923055 
POU2F1OCT1 | OTF1POU class 2 homeobox 1-HPRD12923055 
POU5F1MGC22487 | OCT3 | OCT4 | OTF3 | OTF4POU class 5 homeobox 1-HPRD,BioGRID12923055 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_DN 5835All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
LIU_CDX2_TARGETS_DN 85All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_4 6134All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GROSS_HIF1A_TARGETS_DN 2515All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_UP 7536All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_DN 3822All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
MCCOLLUM_GELDANAMYCIN_RESISTANCE_DN 76All SZGR genes in this pathway
WANG_LSD1_TARGETS_UP 2414All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP 170107All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
CONRAD_STEM_CELL 3927All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
KORKOLA_EMBRYONIC_CARCINOMA_VS_SEMINOMA_UP 2215All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p768774m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-132/2127587641Ahsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-182535541m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-200bc/429477483m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-21522528m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-382105510611Ahsa-miR-382brainGAAGUUGUUCGUGGUGGAUUCG
miR-4507687741Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
hsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-493-5p6596651Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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