SZGR2

Summary ?

GeneID	6664
Symbol	SOX11
Synonyms	MRD27
Description	SRY-box 11
Reference	MIM:600898\|HGNC:HGNC:11191\|Ensembl:ENSG00000176887\|HPRD:02940\|Vega:OTTHUMG00000090333
Gene type	protein-coding
Map location	2p25
Pascal p-value	0.001
Fetal beta	6.165

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003677	DNA binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	TAS	neurite (GO term level: 5)	8666406
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS DN	68	49	All SZGR 2.0 genes in this pathway
DAVICIONI RHABDOMYOSARCOMA PAX FOXO1 FUSION DN	15	11	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS UP	8	7	All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 DN	48	28	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN	242	165	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP	43	27	All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS UP	50	26	All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 DN	25	15	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN	200	112	All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS	74	41	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN	185	111	All SZGR 2.0 genes in this pathway
GUO HEX TARGETS UP	81	54	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP	98	64	All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN	57	39	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS UP	37	27	All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK	75	47	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING	246	152	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP	102	64	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP	111	70	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN	74	47	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
RAFFEL VEGFA TARGETS UP	9	8	All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE B ALL UP	38	22	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1284	1291	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-125/351	5225	5231	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
				hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
				hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
				hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	750	756	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	750	756	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-132/212	6635	6641	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	6635	6641	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-133	592	598	m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	592	598	m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-137	6253	6260	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-137	6253	6260	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-141/200a	7223	7230	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	7223	7230	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-3p	5726	5732	m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-142-5p	5074	5080	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-144	1285	1291	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	6392	6399	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-145	6392	6399	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152	1496	1502	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-153	674	680	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-155	7104	7110	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-186	4444	4451	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-196	5728	5735	1A,m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	5728	5735	1A,m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-204/211	985	992	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
				hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
				hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
				hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
				hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
				hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-217	7220	7226	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-217	7220	7226	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-218	5875	5882	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-223	756	762	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-224	759	765	1A	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-23	810	816	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	810	816	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/367	1425	1432	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	6234	6240	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
				hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-323	810	816	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-3p	5779	5785	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-324-5p	5775	5781	1A	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGUGU
miR-328	5264	5271	1A,m8	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-33	1493	1499	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1493	1499	m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-330	4548	4554	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-376c	7122	7128	1A	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-381	5315	5321	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-383	7144	7150	1A	hsa-miR-383^brain	AGAUCAGAAGGUGAUUGUGGCU
miR-421	5119	5125	1A	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG
miR-448	4700	4706	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-455	1396	1403	1A,m8	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-485-3p	7070	7076	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-490	6818	6824	m8	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-493-5p	725	731	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-499	4256	4262	m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-539	1414	1420	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
				hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
				hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-543	4673	4679	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SOX11