Gene Page: SP3

Summary
GeneID  6670
Symbol  SP3
Synonyms  DKFZp686O1631|SPR-2
Description  Sp3 transcription factor
See related  HGNC:11208|MIM:601804|Ensembl:ENSG00000172845|HPRD:03483|
Locus tag  -
Gene type  protein-coding
Map location  2q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0333 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RAB11FIP40.870.89
PCNXL20.840.88
FBXO100.840.84
RHOBTB20.830.89
OSBP20.820.85
C4orf500.820.85
GABBR20.820.83
CAMK2B0.820.84
CNNM10.820.83
FBXO410.820.87
Top 10 negatively co-expressed genes
GNG11-0.44-0.50
AF347015.21-0.43-0.41
C1orf54-0.43-0.50
AL139819.3-0.43-0.44
SAT1-0.43-0.49
C1orf61-0.42-0.49
AP002478.3-0.41-0.45
S100A13-0.40-0.39
ACAA2-0.40-0.41
MYL12A-0.39-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003682chromatin bindingIEA-
GO:0003690double-stranded DNA bindingIEA-
GO:0005515protein bindingIPI14667819 |16696853 
GO:0008270zinc ion bindingIEA-
GO:0016564transcription repressor activityNAS9278495 
GO:0016563transcription activator activityNAS9278495 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001779natural killer cell differentiationIEA-
GO:0006355regulation of transcription, DNA-dependentIDA12560508 
GO:0030224monocyte differentiationIEA-
GO:0006350transcriptionIEA-
GO:0030218erythrocyte differentiationIEA-
GO:0030217T cell differentiationIEA-
GO:0030851granulocyte differentiationIEA-
GO:0030183B cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIC12560508 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1-HPRD,BioGRID10547281 
GABPAE4TF1-60 | E4TF1A | NFT2 | NRF2 | NRF2AGA binding protein transcription factor, alpha subunit 60kDa-HPRD,BioGRID11237613 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD14970236 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID12176973 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID12151407 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1-HPRD,BioGRID12356736 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD7732011 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Affinity Capture-WesternBioGRID12091390 
-HPRD12943729 
SENP1SuPr-2SUMO1/sentrin specific peptidase 1SENP1 desumoylates sumoylated SP3. This interaction was modeled on a demonstrated interaction between SENP1 from an unspecified species and SP3 from an unspecified species.BIND15546615 
SP1-Sp1 transcription factor-HPRD9329821 
SP4HF1B | MGC130008 | MGC130009 | SPR-1Sp4 transcription factorPhenotypic SuppressionBioGRID7559627 
STK19D6S60 | D6S60E | G11 | HLA-RP1 | MGC117388 | RP1serine/threonine kinase 19-HPRD,BioGRID14667819 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10SP3 interacts with the TNFSF10 promoter.BIND15619633 
ZBTB7ADKFZp547O146 | FBI-1 | FBI1 | LRF | MGC99631 | ZBTB7 | ZNF857A | pokemonzinc finger and BTB domain containing 7A-HPRD12004059 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_CCNE1 4026All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_G1_G2_DN 2518All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_EXPRESSION 4029All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_12HR 3523All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BURTON_ADIPOGENESIS_12 3618All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C2 1815All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
MMS_MOUSE_LYMPH_HIGH_4HRS_UP 3620All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
VANLOO_SP3_TARGETS_DN 8947All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1141147m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061411471Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-129-5p9399m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-1338018071Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-135886892m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1454184241Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1539209261Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-155554560m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-1826546611A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-186678684m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-1886036091Ahsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-1944664721Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-208825831m8hsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-2234394461A,m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-30-3p134140m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-36391971Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-369-3p136213691A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374136313701A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4102412481A,m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4489199261A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-45093991Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-4529229291A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-485-3p151157m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-493-5p5395461A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-5056266321Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-5434644701Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520104810541Ahsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
miR-966556611Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.