Gene Page: SPN

Summary ?
GeneID6693
SymbolSPN
SynonymsCD43|GALGP|GPL115|LSN
Descriptionsialophorin
ReferenceMIM:182160|HGNC:HGNC:11249|Ensembl:ENSG00000197471|HPRD:06770|
Gene typeprotein-coding
Map location16p11.2
Pascal p-value0.425
Fetal beta0.197

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DNM1L0.940.93
NKRF0.930.93
PJA20.930.96
SLC30A90.930.92
UCHL50.930.92
ACTR20.930.92
SERINC10.920.91
PAFAH1B10.920.93
CLTC0.920.93
UBQLN10.920.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.73-0.66
HIGD1B-0.70-0.65
MT-CO2-0.69-0.62
GSDMD-0.69-0.67
AP002478.3-0.68-0.67
AF347015.21-0.68-0.59
AF347015.31-0.67-0.61
ACSF2-0.67-0.65
EIF4EBP3-0.66-0.68
RAB34-0.66-0.72

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityTAS1683685 
GO:0008367bacterial bindingIDA10899905 
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001562response to protozoanIEA-
GO:0001808negative regulation of type IV hypersensitivityIEA-
GO:0007162negative regulation of cell adhesionTAS10753822 
GO:0006968cellular defense responseTAS1683685 
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0007163establishment or maintenance of cell polarityTAS10753822 
GO:0006935chemotaxisTAS10753822 
GO:0008624induction of apoptosis by extracellular signalsIEA-
GO:0042535positive regulation of tumor necrosis factor biosynthetic processIDA10899905 
GO:0042130negative regulation of T cell proliferationIEA-
GO:0042102positive regulation of T cell proliferationIEA-
GO:0042742defense response to bacteriumIDA10899905 
GO:0031295T cell costimulationIEA-
GO:0050688regulation of defense response to virusIEA-
GO:0050776regulation of immune responseIEA-
GO:0045060negative thymic T cell selectionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001931uropodIEASynap (GO term level: 5)-
GO:0005604basement membraneIEA-
GO:0005615extracellular spaceIDA10899905 
GO:0016020membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005887integral to plasma membraneTAS2023632 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL ADHESION MOLECULES CAMS 13493All SZGR 2.0 genes in this pathway
SA MMP CYTOKINE CONNECTION 159All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9165All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 3023All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING DN 4629All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 7851All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR DN 4731All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER DN 2211All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway