Summary ?
GeneID6695
SymbolSPOCK1
SynonymsSPOCK|TESTICAN|TIC1
Descriptionsparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ReferenceMIM:602264|HGNC:HGNC:11251|Ensembl:ENSG00000152377|HPRD:11887|Vega:OTTHUMG00000129157
Gene typeprotein-coding
Map location5q31.2
Pascal p-value0.007
Sherlock p-value0.006
Fetal beta-0.707
eGenePutamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs176002765136433386SPOCK1ENSG00000152377.82.66E-60.01500682gtex_brain_putamen_basal
rs2015433165136436560SPOCK1ENSG00000152377.83.473E-60.01497508gtex_brain_putamen_basal
rs9651665136439130SPOCK1ENSG00000152377.81.641E-60.01494938gtex_brain_putamen_basal
rs9651675136439139SPOCK1ENSG00000152377.81.664E-60.01494929gtex_brain_putamen_basal
rs285675765136440247SPOCK1ENSG00000152377.81.405E-60.01493821gtex_brain_putamen_basal
rs664727235136440304SPOCK1ENSG00000152377.83.621E-60.01493764gtex_brain_putamen_basal
rs14682935136441222SPOCK1ENSG00000152377.83.575E-60.01492846gtex_brain_putamen_basal
rs175220165136447232SPOCK1ENSG00000152377.81.911E-60.01486836gtex_brain_putamen_basal
rs680279025136448540SPOCK1ENSG00000152377.82.408E-60.01485528gtex_brain_putamen_basal
rs7574235136449299SPOCK1ENSG00000152377.82.976E-60.01484769gtex_brain_putamen_basal
rs29059685136457836SPOCK1ENSG00000152377.83.267E-60.01476232gtex_brain_putamen_basal
rs7574245136459562SPOCK1ENSG00000152377.89.726E-70.01474506gtex_brain_putamen_basal
rs9169805136460641SPOCK1ENSG00000152377.89.745E-70.01473427gtex_brain_putamen_basal
rs29059715136461551SPOCK1ENSG00000152377.89.745E-70.01472517gtex_brain_putamen_basal
rs29059735136462383SPOCK1ENSG00000152377.89.745E-70.01471685gtex_brain_putamen_basal
rs29667295136462509SPOCK1ENSG00000152377.81.762E-60.01471559gtex_brain_putamen_basal
rs29667305136464224SPOCK1ENSG00000152377.81.762E-60.01469844gtex_brain_putamen_basal
rs29059765136464933SPOCK1ENSG00000152377.89.745E-70.01469135gtex_brain_putamen_basal
rs29059785136466480SPOCK1ENSG00000152377.85.449E-60.01467588gtex_brain_putamen_basal
rs22402235136466581SPOCK1ENSG00000152377.89.745E-70.01467487gtex_brain_putamen_basal
rs22402245136466764SPOCK1ENSG00000152377.89.745E-70.01467304gtex_brain_putamen_basal
rs65963665136467795SPOCK1ENSG00000152377.81.095E-60.01466273gtex_brain_putamen_basal
rs131862955136468871SPOCK1ENSG00000152377.82.66E-60.01465197gtex_brain_putamen_basal
rs348126695136481759SPOCK1ENSG00000152377.85.449E-60.01452309gtex_brain_putamen_basal
rs14346625136489133SPOCK1ENSG00000152377.81.343E-60.01444935gtex_brain_putamen_basal
rs5650092225136496186SPOCK1ENSG00000152377.85.712E-60.01437882gtex_brain_putamen_basal
rs77130125136502945SPOCK1ENSG00000152377.81.343E-60.01431123gtex_brain_putamen_basal
rs68825095136504046SPOCK1ENSG00000152377.84.451E-70.01430022gtex_brain_putamen_basal
rs358909615136505153SPOCK1ENSG00000152377.81.343E-60.01428915gtex_brain_putamen_basal
rs681789065136512226SPOCK1ENSG00000152377.81.482E-60.01421842gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9181134 
GO:0007155cell adhesionTAS8389704 
GO:0008283cell proliferationTAS8389704 
GO:0006928cell motionTAS8389704 
GO:0007275multicellular organismal developmentTAS8389704 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169118All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175120All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171112All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG UP 13085All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN 10472All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
MAHADEVAN IMATINIB RESISTANCE UP 2315All SZGR 2.0 genes in this pathway
MAHADEVAN GIST MORPHOLOGICAL SWITCH 1511All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 7347All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 4733All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP 3532All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256159All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 8358All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 7551All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 8451All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175116All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 5843All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280183All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE UP 3121All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260174All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 DN 7849All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 12170All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 11066All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE 6440All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS 3523All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275148All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.15665721Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-135944950m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1394294351Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-23326032671A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323326032661Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-326150156m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-375214421501Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA