Gene Page: BRCA1

Summary
GeneID  672
Symbol  BRCA1
Synonyms  BRCAI|BRCC1|IRIS|PSCP|RNF53
Description  breast cancer 1, early onset
See related  HGNC:1100|MIM:113705|Ensembl:ENSG00000012048|HPRD:00218|
Locus tag  -
Gene type  protein-coding
Map location  17q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1208 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0003677DNA bindingIEA-
GO:0003684damaged DNA bindingIEA-
GO:0003713transcription coactivator activityNAS15572661 
GO:0005515protein bindingIEA-
GO:0004842ubiquitin-protein ligase activityNAS15905410 
GO:0008270zinc ion bindingIEA-
GO:0008270zinc ion bindingTAS8944023 
GO:0015631tubulin bindingNAS12214252 
GO:0019899enzyme bindingIPI15965487 
GO:0046872metal ion bindingIEA-
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000075cell cycle checkpointNAS-
GO:0000724double-strand break repair via homologous recombinationIDA17349954 
GO:0009048dosage compensation, by inactivation of X chromosomeIEA-
GO:0006359regulation of transcription from RNA polymerase III promoterTAS10918303 
GO:0006357regulation of transcription from RNA polymerase II promoterTAS10910365 
GO:0006301postreplication repairIDA17349954 
GO:0006281DNA repairIEA-
GO:0006260DNA replicationIEA-
GO:0008630DNA damage response, signal transduction resulting in induction of apoptosisIDA14654789 
GO:0007098centrosome cycleIEA-
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorTAS10918303 
GO:0007059chromosome segregationIMP15965487 
GO:0042981regulation of apoptosisTAS10918303 
GO:0016481negative regulation of transcriptionIDA16288014 
GO:0042127regulation of cell proliferationTAS10918303 
GO:0043009chordate embryonic developmentIEA-
GO:0031398positive regulation of protein ubiquitinationIDA15965487 
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045739positive regulation of DNA repairNAS12242698 
GO:0045893positive regulation of transcription, DNA-dependentNAS15572661 
GO:0045717negative regulation of fatty acid biosynthetic processIMP16326698 
GO:0045786negative regulation of cell cycleIEA-
GO:0043627response to estrogen stimulusIDA8895509 
GO:0046600negative regulation of centriole replicationNAS12214252 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000151ubiquitin ligase complexNAS14976165 
GO:0000793condensed chromosomeIEA-
GO:0005575cellular_componentND-
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005634nucleusTAS10918303 
GO:0005654nucleoplasmEXP10550055 
GO:0005737cytoplasmIEA-
GO:0008274gamma-tubulin ring complexNAS12214252 
GO:0031436BRCA1-BARD1 complexIDA15265711 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-WesternBioGRID12024016 
ACACAACAC | ACC | ACC1 | ACCAacetyl-Coenzyme A carboxylase alpha-HPRD,BioGRID12360400 
BRCA1 interacts with acetyl-CoA carboxylase.BIND12360400 
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Reconstituted ComplexBioGRID10542266 
APLP2APPH | APPL2 | CDEBPamyloid beta (A4) precursor-like protein 2Far WesternBioGRID11746496 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID11016951 |11085509 
ATF1EWS-ATF1 | FUS/ATF-1 | TREB36activating transcription factor 1-HPRD,BioGRID10945975 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedAffinity Capture-Western
Co-purification
Protein-peptide
Reconstituted Complex
BioGRID10550055 |10608806 
|10783165 |10866324 
|11016625 |11114888 
|11278964 
-HPRD2001833 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedBRCA1 physically and functionally interacts with ATR during genotoxic stressBIND11016625 |11278964 
Affinity Capture-Western
Protein-peptide
Reconstituted Complex
BioGRID10608806 |11016625 
|11114888 |11278964 
AURKAAIK | ARK1 | AURA | AURORA2 | BTAK | MGC34538 | STK15 | STK6 | STK7aurora kinase AAffinity Capture-Western
Reconstituted Complex
BioGRID14990569 
BACH1-BTB and CNC homology 1, basic leucine zipper transcription factor 1-HPRD,BioGRID11301010 
BAP1DKFZp686N04275 | FLJ35406 | FLJ37180 | HUCEP-13 | KIAA0272 | UCHL2 | hucep-6BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)-HPRD9528852 
BARD1-BRCA1 associated RING domain 1Affinity Capture-MS
Affinity Capture-Western
Co-crystal Structure
Co-localization
Co-purification
FRET
Reconstituted Complex
Two-hybrid
BioGRID8944023 |9342365 
|9738006 |9788437 
|10026184 |10477523 
|10635334 |11257228 
|11278247 |11301010 
|11498787 |11504724 
|11526114 |11573085 
|11773071 |11925436 
|11927591 |12431996 
|12438698 |12485996 
|12700228 |12732733 
|12887909 |12890688 
|12951069 |14636569 
|14638690 |14647430 
|15159397 |15184379 
-HPRD8944023 |10026184 
|11573085 |11773071 
|12431996 
-HPRD8944023 |10026184 
|11773071 |12431996 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeCo-purificationBioGRID10783165 
BRAPBRAP2 | IMP | RNF52BRCA1 associated protein-HPRD,BioGRID9497340 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetCo-crystal Structure
Protein-peptide
Reconstituted Complex
BioGRID9525870 |11573086 
|14578343 
BRCA1 possesses E3 ubiquitin ligase activity and auto-ubiquitinatesBIND11320250 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onset-HPRD,BioGRID9774970 
BRCA1 interacts with BRCA2.BIND9774970 
BRCC3BRCC36 | C6.1A | CXorf53BRCA1/BRCA2-containing complex, subunit 3Affinity Capture-MS
Affinity Capture-Western
Co-purification
BioGRID14636569 
BREBRCC4 | BRCC45brain and reproductive organ-expressed (TNFRSF1A modulator)Affinity Capture-MS
Affinity Capture-Western
Co-purification
BioGRID14636569 
BRIP1BACH1 | FANCJ | FLJ90232 | MGC126521 | MGC126523 | OFBRCA1 interacting protein C-terminal helicase 1Affinity Capture-MS
Affinity Capture-Western
Co-crystal Structure
Protein-peptide
Reconstituted Complex
BioGRID11877378 |14576433 
|14578343 |15133502 
|15208681 |15242590 
-HPRD11301010 
CCNA1-cyclin A1BRCA1 associates with Cyclin ABIND9244350 |10373534 
Reconstituted ComplexBioGRID9244350 
CCNA2CCN1 | CCNAcyclin A2-HPRD,BioGRID9244350 |10373534 
CCNB1CCNBcyclin B1-HPRD,BioGRID9244350 
BRCA1 is a tyrosine phosphoprotein that associates with Cyclin B1BIND9244350 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1-HPRD,BioGRID9244350 
BRCA1 associates with Cyclin D1BIND9244350 
CCNE1CCNEcyclin E1Affinity Capture-WesternBioGRID17525332 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to M-HPRD,BioGRID9244350 
CDK2p33(CDK2)cyclin-dependent kinase 2BRCA1 associates with CDK2BIND9244350 |10373534 
Affinity Capture-Western
Reconstituted Complex
BioGRID8764100 |9244350 
|10373534 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4-HPRD,BioGRID9244350 
BRCA1 associates with CDK4BIND9244350 
CDK5PSSALREcyclin-dependent kinase 5Reconstituted ComplexBioGRID9244350 
CDK8K35 | MGC126074 | MGC126075cyclin-dependent kinase 8Co-purificationBioGRID9159119 
CDS1CDSCDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1Reconstituted ComplexBioGRID12438214 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)-HPRD,BioGRID10724175 
CLSPNCLASPIN | MGC131612 | MGC131613 | MGC131615claspin homolog (Xenopus laevis)-HPRD,BioGRID15096610 
COBRA1DKFZp586B0519 | KIAA1182 | NELF-B | NELFBcofactor of BRCA1Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11739404 
-HPRD12612062 
CREB1CREB | MGC9284cAMP responsive element binding protein 1Phenotypic EnhancementBioGRID10945975 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID10655477 
CBP interacts with BRCA1. This interaction was modelled on a demonstrated interaction between human BRCA1 and mouse CBP.BIND10655477 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID10403822 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptideReconstituted Complex
Two-hybrid
BioGRID10403822 
BRCA1 is phosphorylated by Casein kinase 2 through a physical interaction with CSNK2BBIND10403822 
CSTF1CstF-50 | CstFp50cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDaReconstituted ComplexBioGRID11257228 
CSTF2CstF-64cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDaAffinity Capture-Western
Co-purification
BioGRID10477523 |11257228 
CTBP1BARS | MGC104684C-terminal binding protein 1-HPRD,BioGRID10196224 
CTCFLBORIS | CTCF-T | MGC163358 | dJ579F20.2CCCTC-binding factor (zinc finger protein)-likeProtein-peptideBioGRID14578343 
DHX9DDX9 | LKP | NDHII | RHADEAH (Asp-Glu-Ala-His) box polypeptide 9-HPRD9662397|12592385 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9662397 |12592385 
DNAJA3FLJ45758 | TID1 | hTid-1DnaJ (Hsp40) homolog, subfamily A, member 3Protein-peptideBioGRID14578343 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1BRCA1 associates with E2F-1BIND9244350 
-HPRD9244350 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingBRCA1 associates with E2F-4BIND9244350 
-HPRD,BioGRID9244350 
ELK1-ELK1, member of ETS oncogene family-HPRD11313879 
ELK4SAP1ELK4, ETS-domain protein (SRF accessory protein 1)Affinity Capture-Western
Reconstituted Complex
BioGRID11313879 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID10655477 
p300 interacts with BRCA1.BIND10655477 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD10334989 
Affinity Capture-Western
Co-localization
Reconstituted Complex
BioGRID11244506 |11493692 
|11782371 |12400015 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Reconstituted ComplexBioGRID11313879 
ETS2ETS2IT1v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)ETS2 (Ets-2) interacts with BRCA1 promoter. This interaction was modeled on a demonstrated interaction between ETS2 from an unspecified species and BRCA1 promoter from an unspecified species.BIND12637547 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group ABRCA1 interacts with FANCA.BIND12354784 
-HPRD,BioGRID12354784 
FANCD2DKFZp762A223 | FA-D2 | FA4 | FACD | FAD | FAD2 | FANCD | FLJ23826Fanconi anemia, complementation group D2Co-localization
Reconstituted Complex
Two-hybrid
BioGRID12887909 |14499622 
-HPRD11239454 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID14550570 |14986435 
FLI1EWSR2 | SIC-1Friend leukemia virus integration 1Reconstituted ComplexBioGRID11313879 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD11602572 
GTF2E1FE | TF2E1 | TFIIE-Ageneral transcription factor IIE, polypeptide 1, alpha 56kDaCo-purificationBioGRID9159119 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDaCo-purificationBioGRID9159119 
GTF2H4TFB2 | TFIIHgeneral transcription factor IIH, polypeptide 4, 52kDaCo-purificationBioGRID9159119 
H2AFXH2A.X | H2A/X | H2AXH2A histone family, member XCo-localization
Reconstituted Complex
BioGRID10959836 |11927591 
|12485996 
H2AFYH2A.y | H2A/y | H2AF12M | H2AFJ | MACROH2A1.1 | mH2A1 | macroH2A1.2H2A histone family, member YCo-localizationBioGRID12419249 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1BRCA1 interacts with HDAC1BIND10220405 
-HPRD,BioGRID10220405 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID10220405 
BRCA1 interacts with HDAC2BIND10220405 
HIST2H2ACH2A | H2A-GL101 | H2A/q | H2AFQ | MGC74460histone cluster 2, H2acReconstituted ComplexBioGRID11927591 
HIST2H3CH3 | H3.2 | H3/M | H3F2 | H3FM | MGC9629histone cluster 2, H3cCo-localizationBioGRID12419249 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8Two-hybridBioGRID9738006 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID11163768 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID11163768 
JUNAP-1 | AP1 | c-Junjun oncogeneBRCA1 interacts with c-Jun.BIND12080089 
-HPRD,BioGRID12080089 
JUNBAP-1jun B proto-oncogeneBRCA1 interacts with JunB.BIND12080089 
-HPRD,BioGRID12080089 
JUNDAP-1jun D proto-oncogene-HPRD,BioGRID12080089 
BRCA1 interacts with JunD.BIND12080089 
KIF1BCMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844kinesin family member 1BProtein-peptideBioGRID14578343 
KPNA2IPOA1 | QIP2 | RCH1 | SRP1alphakaryopherin alpha 2 (RAG cohort 1, importin alpha 1)Two-hybridBioGRID8955125 
-HPRD9497340 
LMO4-LIM domain only 4-HPRD,BioGRID11751867 
The LIM domain protein LMO4 interacts with BRCA1BIND11751867 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3Affinity Capture-Western
Two-hybrid
BioGRID15205325 
BRCA1 interacts with MEKK3.BIND15205325 
MAP4K4FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIKmitogen-activated protein kinase kinase kinase kinase 4Protein-peptideBioGRID14578343 
MDC1DKFZp781A0122 | KIAA0170 | MGC166888 | NFBD1mediator of DNA damage checkpoint 1-HPRD12607005 
Affinity Capture-WesternBioGRID17525332 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1BRCA1 interacts with TRAP220.BIND15208681 
Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID15208681 
MED13ARC250 | DRIP250 | HSPC221 | KIAA0593 | THRAP1 | TRAP240mediator complex subunit 13Affinity Capture-MSBioGRID15208681 
MED17CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80mediator complex subunit 17Affinity Capture-MS
Co-purification
BioGRID11504724 |12154023 
|15208681 
MED21SRB7 | SURB7mediator complex subunit 21-HPRD,BioGRID9159119 
MED23CRSP130 | CRSP133 | CRSP3 | DKFZp434H0117 | DRIP130 | SUR2mediator complex subunit 23Affinity Capture-MSBioGRID15208681 
MED24ARC100 | CRSP100 | CRSP4 | DRIP100 | KIAA0130 | MGC8748 | THRAP4 | TRAP100mediator complex subunit 24Affinity Capture-MS
Affinity Capture-Western
BioGRID15208681 
MLH1COCA2 | FCC2 | HNPCC | HNPCC2 | MGC5172 | hMLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)-HPRD,BioGRID10783165 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Affinity Capture-Western
Co-localization
Co-purification
Reconstituted Complex
BioGRID10426999 |10783165 
|11353843 |11504724 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)-HPRD,BioGRID11498787 
BRCA1 interacts with MSH2 in the absence of ADP-MSH2 interaction.BIND10783165 
MSH3DUP | MGC163306 | MGC163308 | MRP1mutS homolog 3 (E. coli)Protein-peptide
Reconstituted Complex
BioGRID11498787 |14578343 
MSH6GTBP | HNPCC5 | HSAPmutS homolog 6 (E. coli)BRCA1 associates with MSH6.BIND10783165 |11498787 
-HPRD,BioGRID11498787 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID9788437 
BRCA1 association with c-Myc, a proto-oncogene that is implicated in tumorigenesis, embryonic development and apoptosis, inhibits its transcriptional and transforming activity in cells.BIND9788437 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrin-HPRD,BioGRID10426999 |10783165 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2Protein-peptide
Reconstituted Complex
BioGRID11085509 |14578343 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3Protein-peptideBioGRID14578343 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD12700228 
NFYACBF-A | CBF-B | FLJ11236 | HAP2 | NF-YAnuclear transcription factor Y, alpha-HPRD,BioGRID11777930 
BRCA1 interacts with NF-YABIND11777930 
NMI-N-myc (and STAT) interactor-HPRD,BioGRID11916966 
BRCA1 interacts with Nmi.BIND11916966 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID15184379 
NUFIP1NUFIP | bA540M5.1nuclear fragile X mental retardation protein interacting protein 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID15107825 
BRCA1 interacts with NUFIP.BIND15107825 
NUP153HNUP153 | N153nucleoporin 153kDaProtein-peptideBioGRID14578343 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)Affinity Capture-WesternBioGRID17525332 
ORC3LLAT | LATHEO | ORC3origin recognition complex, subunit 3-like (yeast)Affinity Capture-WesternBioGRID17525332 
PCTK1FLJ16665 | PCTAIRE | PCTAIRE1 | PCTGAIREPCTAIRE protein kinase 1Two-hybridBioGRID9738006 
PEG3DKFZp781A095 | KIAA0287 | PW1 | ZSCAN24paternally expressed 3Far WesternBioGRID11746496 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD4506230 |9159119 
|12154023|10725406 
-HPRD4506230 |9159119 
|12154023 
Affinity Capture-Western
Co-purification
BioGRID9159119 |11504724 
|12955082 |14506230 
POLR2KABC10-alpha | RPABC4 | RPB10alpha | RPB12 | RPB7.0 | hRPB7.0 | hsRPB10apolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa-HPRD10725406 
POU2F1OCT1 | OTF1POU class 2 homeobox 1Affinity Capture-WesternBioGRID11777930 
BRCA1 interacts with Oct-1.BIND11777930 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoformAffinity Capture-Western
Reconstituted Complex
BioGRID12438214 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptideProtein-peptideBioGRID10608806 
RAD50RAD50-2 | hRad50RAD50 homolog (S. cerevisiae)-HPRD,BioGRID10426999 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)-HPRD,BioGRID9774970 
BRCA1 and Rad51 associate in mitotic and meiotic cellsBIND9008167 
-HPRD9008167 |9774970|9774970 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID10220405 
BRCA1 interacts with Rb.BIND10518542 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4BRCA1 interacts with RbAp48.BIND10220405 
-HPRD,BioGRID10220405 
RBBP7MGC138867 | MGC138868 | RbAp46retinoblastoma binding protein 7BRCA1 interacts with RbAp46.BIND10220405 
-HPRD,BioGRID10220405 
RBBP8CTIP | RIMretinoblastoma binding protein 8-HPRD9738006 |10196224 
Affinity Capture-Western
Protein-peptide
Reconstituted Complex
Two-hybrid
BioGRID9738006 |9811458 
|10196224 |10764811 
|10910365 |11689934 
|14578343 
BRCA1 interacts with CtIP.BIND9811458 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)Co-localization
Reconstituted Complex
BioGRID11521194 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)Co-localization
Reconstituted Complex
BioGRID11521194 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID12700228 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDa-HPRD,BioGRID10783165 
RPL31MGC88191ribosomal protein L31Far Western
Reconstituted Complex
BioGRID11746496 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2BRCA1 interacts with Smad2. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad2 from an unspecified species.BIND15735739 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3BRCA1 interacts with Smad3.BIND15735739 
SMAD4DPC4 | JIP | MADH4SMAD family member 4BRCA1 interacts with Smad4. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad4 from an unspecified species.BIND15735739 
SMARCA2BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Affinity Capture-WesternBioGRID15034933 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID10943845 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Co-purificationBioGRID10943845 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Co-purificationBioGRID10943845 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Co-purificationBioGRID10943845 
SMARCD2BAF60B | CRACD2 | PRO2451 | Rsc6pSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2Co-purificationBioGRID10943845 
SMC1ACDLS2 | DKFZp686L19178 | DXS423E | KIAA0178 | MGC138332 | SB1.8 | SMC1 | SMC1L1 | SMC1alpha | SMCBstructural maintenance of chromosomes 1A-HPRD11877377 
SP1-Sp1 transcription factor-HPRD10720440 
BRCA1 interacts with Sp1.BIND12706836 
Affinity Capture-WesternBioGRID12706836 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID10792030 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD11163768 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID12459499 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDaTOP2A (Topo II) interacts with BRCA1BIND15965487 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53BRCA1a interacts with p53.BIND9926942 
BRCA1 physically associates with p53 and stimulates its transcriptional activityBIND9582019 
-HPRD,BioGRID9482880 
TP53BP153BP1 | FLJ41424 | MGC138366 | p202tumor protein p53 binding protein 1Affinity Capture-WesternBioGRID17525332 
TUBG1TUBG | TUBGCP1tubulin, gamma 1-HPRD,BioGRID9789027 |11691781 
UBA1A1S9 | A1S9T | A1ST | AMCX1 | GXP1 | MGC4781 | SMAX2 | UBA1A | UBE1 | UBE1Xubiquitin-like modifier activating enzyme 1Reconstituted ComplexBioGRID11278247 |11927591 
|12438698 |12485996 
|12887909 |14638690 
|15184379 
UBBFLJ25987 | MGC8385ubiquitin BBRCA1 interacts with Ub. This interaction was modelled on a demonstrated interaction between human BRCA1 and Ub from an unspecified source.BIND11320250 
UBE2D1E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5Aubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)Reconstituted ComplexBioGRID11278247 |11927591 
|12438698 |12485996 
|12732733 |12887909 
|12890688 |14636569 
|14638690 |15184379 
UBE2D3E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5Cubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)-HPRD12732733 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD,BioGRID12732733 
UBE3AANCR | AS | E6-AP | EPVE6AP | FLJ26981 | HPVE6Aubiquitin protein ligase E3AReconstituted ComplexBioGRID12890688 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interacting-HPRD,BioGRID14502648 
VCPIBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97valosin-containing protein-HPRD,BioGRID10855792 
WNT2BWNT13 | XWNT2wingless-type MMTV integration site family, member 2BFar WesternBioGRID11746496 
XISTDKFZp779P0129 | DXS1089 | DXS399E | NCRNA00001 | SXI1 | XCE | XIC | swd66X (inactive)-specific transcript (non-protein coding)Co-localizationBioGRID12419249 |15065664 
XRCC1RCCX-ray repair complementing defective repair in Chinese hamster cells 1-HPRD11352725 
ZCCHC8DKFZp434E2220zinc finger, CCHC domain containing 8Affinity Capture-WesternBioGRID17525332 
ZNF350ZBRK1 | ZFQRzinc finger protein 350-HPRD,BioGRID11090615 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
BIOCARTA_ATM_PATHWAY 2016All SZGR genes in this pathway
BIOCARTA_CARM_ER_PATHWAY 3527All SZGR genes in this pathway
BIOCARTA_G2_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_ATRBRCA_PATHWAY 2112All SZGR genes in this pathway
PID_FANCONI_PATHWAY 4728All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_ATM_PATHWAY 3425All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_ERA_GENOMIC_PATHWAY 6537All SZGR genes in this pathway
PID_AURORA_A_PATHWAY 3120All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
PID_BARD1_PATHWAY 2919All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 1711All SZGR genes in this pathway
REACTOME_FANCONI_ANEMIA_PATHWAY 2511All SZGR genes in this pathway
REACTOME_DOUBLE_STRAND_BREAK_REPAIR 2414All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_MEIOTIC_RECOMBINATION 8662All SZGR genes in this pathway
REACTOME_MEIOTIC_SYNAPSIS 7357All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SCIBETTA_KDM5B_TARGETS_DN 8155All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
BUSA_SAM68_TARGETS_DN 65All SZGR genes in this pathway
KONG_E2F3_TARGETS 9758All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP 181108All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_12 118All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
XU_AKT1_TARGETS_6HR 2718All SZGR genes in this pathway
XU_AKT1_TARGETS_48HR 96All SZGR genes in this pathway
YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN 8748All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
WANG_RESPONSE_TO_BEXAROTENE_UP 3417All SZGR genes in this pathway
KARAKAS_TGFB1_SIGNALING 1815All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
OHM_METHYLATED_IN_ADULT_CANCERS 2723All SZGR genes in this pathway
OHM_EMBRYONIC_CARCINOMA_UP 65All SZGR genes in this pathway
KAUFFMANN_MELANOMA_RELAPSE_UP 6125All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
MENSSEN_MYC_TARGETS 5335All SZGR genes in this pathway
KANNAN_TP53_TARGETS_DN 2115All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_UP 5240All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_DN 2616All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_UP 6042All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_UP 2923All SZGR genes in this pathway
NAKAJIMA_MAST_CELL 4634All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
ZHANG_TLX_TARGETS_DN 8950All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
UROSEVIC_RESPONSE_TO_IMIQUIMOD 2314All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_S 16286All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
THILLAINADESAN_ZNF217_TARGETS_UP 4422All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
YU_BAP1_TARGETS 2921All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR 8549All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/21212421248m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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