Gene Page: STAT2
Summary ?
GeneID | 6773 |
Symbol | STAT2 |
Synonyms | IMD44|ISGF-3|P113|STAT113 |
Description | signal transducer and activator of transcription 2 |
Reference | MIM:600556|HGNC:HGNC:11363|Ensembl:ENSG00000170581|HPRD:02778|Vega:OTTHUMG00000170760 |
Gene type | protein-coding |
Map location | 12q13.3 |
Pascal p-value | 0.038 |
Sherlock p-value | 0.577 |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs4436485 | chr10 | 103245360 | STAT2 | 6773 | 0.09 | trans | ||
rs2796843 | chr13 | 51240181 | STAT2 | 6773 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
PLCB2 | 0.64 | 0.57 |
ARHGAP4 | 0.62 | 0.60 |
MPPE1 | 0.59 | 0.52 |
EXOC3L | 0.58 | 0.56 |
LRRC56 | 0.57 | 0.59 |
RRP7A | 0.56 | 0.58 |
PPP1R16A | 0.56 | 0.63 |
ACAP1 | 0.56 | 0.42 |
DUSP15 | 0.55 | 0.47 |
RFNG | 0.55 | 0.59 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.27 | -0.34 | -0.34 |
MT-ATP8 | -0.34 | -0.35 |
AF347015.31 | -0.34 | -0.32 |
AF347015.2 | -0.32 | -0.34 |
AF347015.21 | -0.31 | -0.30 |
AF347015.8 | -0.31 | -0.30 |
AF347015.33 | -0.31 | -0.31 |
AL139819.3 | -0.30 | -0.34 |
MT-CO2 | -0.29 | -0.29 |
AF347015.15 | -0.29 | -0.30 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
CREBBP | CBP | KAT3A | RSTS | CREB binding protein | - | HPRD,BioGRID | 8848048 |10464260 |
EP300 | KAT3B | p300 | E1A binding protein p300 | Reconstituted Complex | BioGRID | 10464260 |
EP300 | KAT3B | p300 | E1A binding protein p300 | Stat2 interacts with p300. | BIND | 10464260 |
IFNAR1 | AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRC | interferon (alpha, beta and omega) receptor 1 | Affinity Capture-Western Reconstituted Complex | BioGRID | 7559568 |8605876 |9121453 |
IFNAR1 | AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRC | interferon (alpha, beta and omega) receptor 1 | - | HPRD | 7559568|8605876 |11786546 |
IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | - | HPRD,BioGRID | 9121453 |11786546 |
IRF9 | IRF-9 | ISGF3 | ISGF3G | p48 | interferon regulatory factor 9 | - | HPRD,BioGRID | 9242679 |
IRF9 | IRF-9 | ISGF3 | ISGF3G | p48 | interferon regulatory factor 9 | Stat2 interacts with p48. This interaction is modelled on a demonstrated interaction between stat2 from an unspecified species and human p48. | BIND | 8943351 |
MED14 | CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170 | mediator complex subunit 14 | - | HPRD,BioGRID | 12509459 |
SMARCA4 | BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2b | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | - | HPRD,BioGRID | 12244326 |
SMARCC1 | BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | Affinity Capture-Western | BioGRID | 12244326 |
SMARCC2 | BAF170 | CRACC2 | Rsc8 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | Affinity Capture-Western | BioGRID | 12244326 |
SMARCE1 | BAF57 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | Affinity Capture-Western | BioGRID | 12244326 |
STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | STAT1 interacts with STAT2. | BIND | 15467722 |
STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | - | HPRD,BioGRID | 8621447 |10446176 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | All SZGR 2.0 genes in this pathway |
BIOCARTA BIOPEPTIDES PATHWAY | 45 | 35 | All SZGR 2.0 genes in this pathway |
BIOCARTA EGF PATHWAY | 31 | 25 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL10 PATHWAY | 17 | 14 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL22BP PATHWAY | 16 | 12 | All SZGR 2.0 genes in this pathway |
BIOCARTA PDGF PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
ST TYPE I INTERFERON PATHWAY | 9 | 8 | All SZGR 2.0 genes in this pathway |
PID IL27 PATHWAY | 26 | 20 | All SZGR 2.0 genes in this pathway |
PID CXCR4 PATHWAY | 102 | 78 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON ALPHA BETA SIGNALING | 64 | 50 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF IFNA SIGNALING | 24 | 22 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON SIGNALING | 159 | 116 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
BARRIER COLON CANCER RECURRENCE DN | 20 | 16 | All SZGR 2.0 genes in this pathway |
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP | 182 | 110 | All SZGR 2.0 genes in this pathway |
KINSEY TARGETS OF EWSR1 FLII FUSION DN | 329 | 219 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
STREICHER LSM1 TARGETS UP | 44 | 34 | All SZGR 2.0 genes in this pathway |
AUNG GASTRIC CANCER | 54 | 20 | All SZGR 2.0 genes in this pathway |
DAUER STAT3 TARGETS UP | 49 | 35 | All SZGR 2.0 genes in this pathway |
YAN ESCAPE FROM ANOIKIS | 24 | 19 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
GARCIA TARGETS OF FLI1 AND DAX1 UP | 57 | 34 | All SZGR 2.0 genes in this pathway |
PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 | 52 | 32 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
WORSCHECH TUMOR REJECTION UP | 56 | 32 | All SZGR 2.0 genes in this pathway |
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
QI PLASMACYTOMA DN | 100 | 63 | All SZGR 2.0 genes in this pathway |
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK DN | 20 | 13 | All SZGR 2.0 genes in this pathway |
HOFMANN MYELODYSPLASTIC SYNDROM RISK DN | 23 | 12 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA LB DN | 44 | 23 | All SZGR 2.0 genes in this pathway |
CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |
YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE | 78 | 48 | All SZGR 2.0 genes in this pathway |
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION | 128 | 81 | All SZGR 2.0 genes in this pathway |
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |