SZGR2

Summary ?

GeneID	6837
Symbol	MED22
Synonyms	MED24\|SURF5\|surf-5
Description	mediator complex subunit 22
Reference	MIM:185641\|HGNC:HGNC:11477\|Ensembl:ENSG00000148297\|HPRD:01713\|Vega:OTTHUMG00000020869
Gene type	protein-coding
Map location	9q34.2
Pascal p-value	0.308
Sherlock p-value	0.008
Fetal beta	0.717

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NONO	0.96	0.93
ANP32A	0.95	0.92
KDM1	0.95	0.94
INTS7	0.95	0.94
FUBP1	0.95	0.95
XRN2	0.95	0.93
EIF4B	0.94	0.93
DHX9	0.94	0.95
MSH6	0.94	0.94
RBMX	0.94	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
HLA-F	-0.70	-0.81
AF347015.31	-0.70	-0.91
FXYD1	-0.70	-0.92
AIFM3	-0.70	-0.81
TSC22D4	-0.70	-0.84
MT-CO2	-0.69	-0.91
AF347015.33	-0.69	-0.89
C5orf53	-0.69	-0.76
PTH1R	-0.69	-0.79
IFI27	-0.69	-0.90

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
GOLM1	C9orf155 \| FLJ22634 \| FLJ23608 \| GOLPH2 \| GP73 \| PSEC0257 \| bA379P1.3	golgi membrane protein 1	Two-hybrid	BioGRID	16169070
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS	BioGRID	12584197 \|15175163
MED11	HSPC296 \| MGC88387	mediator complex subunit 11	-	HPRD,BioGRID	12584197
MED11	HSPC296 \| MGC88387	mediator complex subunit 11	Surf5 interacts with HSPC296. This interaction was modelled on a demonstrated interaction between human Surf5 and mouse HSPC296.	BIND	12584197
MED17	CRSP6 \| CRSP77 \| DRIP80 \| FLJ10812 \| TRAP80	mediator complex subunit 17	TRAP80 interacts with Surf5.	BIND	12584197
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	Affinity Capture-MS	BioGRID	15175163
MED25	ACID1 \| ARC92 \| DKFZp434K0512 \| MGC70671 \| P78 \| PTOV2 \| TCBAP0758	mediator complex subunit 25	Affinity Capture-Western	BioGRID	14638676
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	Affinity Capture-MS	BioGRID	15175163
MED27	CRAP34 \| CRSP34 \| CRSP8 \| MGC11274 \| TRAP37	mediator complex subunit 27	Reconstituted Complex	BioGRID	12584197
MED27	CRAP34 \| CRSP34 \| CRSP8 \| MGC11274 \| TRAP37	mediator complex subunit 27	TRAP37 interacts with Surf5.	BIND	12584197
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	-	HPRD	14576168
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS	BioGRID	15175163
MED30	MGC9890 \| THRAP6 \| TRAP25	mediator complex subunit 30	-	HPRD,BioGRID	12584197
MED30	MGC9890 \| THRAP6 \| TRAP25	mediator complex subunit 30	Surf5 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human Surf5 and mouse TRAP25.	BIND	12584197
MED7	CRSP33 \| CRSP9 \| MGC12284	mediator complex subunit 7	Reconstituted Complex	BioGRID	12584197
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	-	HPRD	14638676
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	Affinity Capture-MS	BioGRID	15175163
THOC7	FLJ23445 \| NIF3L1BP1 \| fSAP24	THO complex 7 homolog (Drosophila)	Reconstituted Complex	BioGRID	12584197

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4	61	34	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC	210	123	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2	86	50	All SZGR 2.0 genes in this pathway

Gene Page: MED22