Gene Page: TACR1

Summary ?
GeneID6869
SymbolTACR1
SynonymsNK1R|NKIR|SPR|TAC1R
Descriptiontachykinin receptor 1
ReferenceMIM:162323|HGNC:HGNC:11526|Ensembl:ENSG00000115353|HPRD:01208|Vega:OTTHUMG00000129973
Gene typeprotein-coding
Map location2p12
Pascal p-value0.054
Sherlock p-value0.334
Fetal beta0.152

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GPER0.870.83
FAM38A0.830.84
SLC6A120.810.79
SOX180.800.79
RIN30.790.80
BCAM0.780.81
HLA-E0.780.79
GPR37L10.780.71
COL5A30.770.73
TINAGL10.770.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRG1-0.64-0.71
PSMA4-0.60-0.63
FARSB-0.60-0.60
ASNSD1-0.59-0.59
SPATA7-0.59-0.59
C18orf21-0.59-0.60
COQ3-0.59-0.59
TXNL1-0.58-0.60
GGPS1-0.58-0.56
POLB-0.57-0.64

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004995tachykinin receptor activityIEA-
GO:0004995tachykinin receptor activityTAS8985172 
GO:0005515protein bindingIPI17986524 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)TAS1657150 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007217tachykinin signaling pathwayTAS8985172 
GO:0007165signal transductionIEA-
GO:0009582detection of abiotic stimulusTAS9537323 
GO:0006954inflammatory responseTAS10854844 
GO:0007638mechanosensory behaviorTAS9537323 
GO:0048265response to painIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005886plasma membraneTAS10611312 
GO:0005887integral to plasma membraneTAS1657150 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 1 UP 3618All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210148All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway