Gene Page: TAF7
Summary ?
| GeneID | 6879 |
| Symbol | TAF7 |
| Synonyms | TAF2F|TAFII55 |
| Description | TATA-box binding protein associated factor 7 |
| Reference | MIM:600573|HGNC:HGNC:11541|Ensembl:ENSG00000178913|HPRD:07196|Vega:OTTHUMG00000129628 |
| Gene type | protein-coding |
| Map location | 5q31 |
| Pascal p-value | 0.073 |
| Sherlock p-value | 0.415 |
| Fetal beta | 0.256 |
| DMG | 2 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 3 |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 3 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0032 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg06284322 | 5 | 140700662 | TAF7 | -0.019 | 0.96 | DMG:Nishioka_2013 | |
| cg15361590 | 5 | 140864701 | TAF7 | 2.817E-4 | 5.765 | DMG:vanEijk_2014 | |
| cg11647681 | 5 | 140810161 | TAF7 | 0.003 | 2.993 | DMG:vanEijk_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9355872 | chr6 | 161534332 | TAF7 | 6879 | 0.2 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FLOT1 | 0.88 | 0.86 |
| C19orf62 | 0.87 | 0.84 |
| UQCRC1 | 0.86 | 0.82 |
| FBXL15 | 0.86 | 0.87 |
| RNF167 | 0.85 | 0.83 |
| TMEM53 | 0.85 | 0.85 |
| TRAPPC1 | 0.85 | 0.84 |
| AP2S1 | 0.85 | 0.82 |
| KHK | 0.85 | 0.82 |
| MRPL4 | 0.84 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.56 | -0.30 |
| MT-ATP8 | -0.51 | -0.28 |
| AF347015.26 | -0.48 | -0.26 |
| AF347015.8 | -0.48 | -0.23 |
| AF347015.2 | -0.47 | -0.22 |
| AF347015.21 | -0.47 | -0.20 |
| AC010300.1 | -0.45 | -0.38 |
| NSBP1 | -0.44 | -0.39 |
| AF347015.15 | -0.44 | -0.22 |
| EDN1 | -0.44 | -0.33 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003713 | transcription coactivator activity | TAS | 7824954 | |
| GO:0005515 | protein binding | TAS | 7824954 | |
| GO:0016251 | general RNA polymerase II transcription factor activity | TAS | 7824954 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0030520 | estrogen receptor signaling pathway | IEA | - | |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005794 | Golgi apparatus | IDA | 18029348 | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005669 | transcription factor TFIID complex | IDA | 14580349 | |
| GO:0005730 | nucleolus | IDA | 18029348 | |
| GO:0005737 | cytoplasm | IDA | 18029348 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG BASAL TRANSCRIPTION FACTORS | 36 | 24 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| CHEN NEUROBLASTOMA COPY NUMBER GAINS | 50 | 35 | All SZGR 2.0 genes in this pathway |
| FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP | 151 | 100 | All SZGR 2.0 genes in this pathway |
| HEDVAT ELF4 TARGETS UP | 12 | 8 | All SZGR 2.0 genes in this pathway |
| WANG CISPLATIN RESPONSE AND XPC DN | 228 | 146 | All SZGR 2.0 genes in this pathway |
| SESTO RESPONSE TO UV C0 | 107 | 72 | All SZGR 2.0 genes in this pathway |
| KONDO PROSTATE CANCER HCP WITH H3K27ME3 | 97 | 72 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |