Gene Page: TAF13
Summary ?
| GeneID | 6884 |
| Symbol | TAF13 |
| Synonyms | TAF(II)18|TAF2K|TAFII-18|TAFII18 |
| Description | TATA-box binding protein associated factor 13 |
| Reference | MIM:600774|HGNC:HGNC:11546| |
| Gene type | protein-coding |
| Map location | 1p13.3 |
| Pascal p-value | 0.551 |
| TADA p-value | 4.86E-6 |
| Fetal beta | -0.582 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| Expression | Meta-analysis of gene expression | P value: 1.684 |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TAF13 | chr1 | 109607282 | G | A | NM_005645 | p.80R>* | nonsense | Schizophrenia | DNM:Fromer_2014 | ||
| TAF13 | chr1 | 109617626..109617630 | CTCTT | C | NM_005645 | . | frameshift | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HP1BP3 | 0.97 | 0.96 |
| ADNP | 0.96 | 0.96 |
| KDM4A | 0.96 | 0.96 |
| THRAP3 | 0.96 | 0.97 |
| CNOT6 | 0.96 | 0.96 |
| CHD8 | 0.96 | 0.96 |
| NCOA5 | 0.96 | 0.96 |
| MSL2 | 0.96 | 0.96 |
| MED1 | 0.96 | 0.97 |
| RBM16 | 0.96 | 0.97 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.78 | -0.89 |
| MT-CO2 | -0.77 | -0.89 |
| IFI27 | -0.75 | -0.88 |
| AF347015.27 | -0.75 | -0.86 |
| C5orf53 | -0.75 | -0.76 |
| FXYD1 | -0.75 | -0.87 |
| AF347015.33 | -0.74 | -0.84 |
| AIFM3 | -0.73 | -0.76 |
| HLA-F | -0.73 | -0.75 |
| HIGD1B | -0.73 | -0.88 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003700 | transcription factor activity | TAS | 9695952 | |
| GO:0005515 | protein binding | IPI | 9695952 | |
| GO:0016251 | general RNA polymerase II transcription factor activity | TAS | 7729427 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | EXP | 8946909 | |
| GO:0006368 | RNA elongation from RNA polymerase II promoter | EXP | 9405375 | |
| GO:0006350 | transcription | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005654 | nucleoplasm | EXP | 1939271 |2449431 |8946909 | |
| GO:0005669 | transcription factor TFIID complex | TAS | 7729427 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG BASAL TRANSCRIPTION FACTORS | 36 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II TRANSCRIPTION | 105 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | 41 | 21 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTION | 210 | 127 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 61 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV LIFE CYCLE | 125 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 104 | 61 | All SZGR 2.0 genes in this pathway |
| CONCANNON APOPTOSIS BY EPOXOMICIN UP | 239 | 157 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING DN | 49 | 37 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| HOFMANN CELL LYMPHOMA UP | 50 | 35 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 16HR UP | 225 | 139 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 10HR UP | 101 | 69 | All SZGR 2.0 genes in this pathway |
| CAMPS COLON CANCER COPY NUMBER DN | 74 | 34 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 30MIN DN | 150 | 99 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |