Gene Page: TAL1

Summary ?
GeneID6886
SymbolTAL1
SynonymsSCL|TCL5|bHLHa17|tal-1
DescriptionT-cell acute lymphocytic leukemia 1
ReferenceMIM:187040|HGNC:HGNC:11556|Ensembl:ENSG00000162367|HPRD:01753|Vega:OTTHUMG00000007847
Gene typeprotein-coding
Map location1p32
Pascal p-value0.092
Sherlock p-value0.089
Fetal beta-0.598

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EPAS10.770.80
FOXF10.740.78
TBX20.740.75
SOX180.740.69
GPER0.730.73
HLA-E0.720.77
APOLD10.710.69
ABCB10.710.74
GPR37L10.710.69
TIMP30.710.74
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRG1-0.54-0.60
POLB-0.52-0.58
MED19-0.52-0.55
C12orf45-0.51-0.62
TMSB10-0.51-0.59
RP9-0.50-0.55
PSMB7-0.50-0.56
C11orf57-0.50-0.58
NDUFAF2-0.50-0.59
C18orf21-0.50-0.54

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRD1BRL | BRPF1 | BRPF2 | DKFZp686F0325bromodomain containing 1Affinity Capture-MSBioGRID16407974 
CBFA2T2DKFZp313F2116 | EHT | MTGR1 | ZMYND3core-binding factor, runt domain, alpha subunit 2; translocated to, 2Affinity Capture-MSBioGRID16407974 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID16407974 
DRG1DKFZp434N1827 | NEDD3developmentally regulated GTP binding protein 1-HPRD9824680 
ELSPBP1E12 | HE12epididymal sperm binding protein 1in vivo
Two-hybrid		BioGRID8159721 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-Western
Reconstituted Complex		BioGRID10490830 
GATA1ERYF1 | GF-1 | GF1 | NFE1GATA binding protein 1 (globin transcription factor 1)Affinity Capture-MS
Two-hybrid		BioGRID7568177 |16407974 
GATA2MGC2306 | NFE1BGATA binding protein 2Two-hybridBioGRID7568177 
GATA3HDR | MGC2346 | MGC5199 | MGC5445GATA binding protein 3Affinity Capture-WesternBioGRID9819382 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD10688671 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-MSBioGRID16407974 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-MSBioGRID16407974 
LDB1CLIM2 | NLILIM domain binding 1Affinity Capture-MS
Affinity Capture-Western		BioGRID16407974 
LMO1MGC116692 | RBTN1 | RHOM1 | TTG1LIM domain only 1 (rhombotin 1)-HPRD,BioGRID8078932 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)-HPRD,BioGRID7568177 |7957052 
NCAPG2CAP-G2 | FLJ20311 | LUZP5 | MTB | hCAP-G2non-SMC condensin II complex, subunit G2-HPRD,BioGRID14729962 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1Affinity Capture-MSBioGRID16407974 
PRKCQMGC126514 | MGC141919 | PRKCT | nPKC-thetaprotein kinase C, thetaTwo-hybridBioGRID10383400 
RCC1CHC1 | RCC1-Iregulator of chromosome condensation 1Affinity Capture-MSBioGRID16407974 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Affinity Capture-Western
Reconstituted Complex		BioGRID10688671 
SP1-Sp1 transcription factor-HPRD,BioGRID12239153 
SSBP1SSBPsingle-stranded DNA binding protein 1Affinity Capture-MSBioGRID16407974 
SSBP2DKFZp686F03273 | HSPC116single-stranded DNA binding protein 2Affinity Capture-MSBioGRID16407974 
SSBP3CSDP | FLJ10355 | SSDP | SSDP1single stranded DNA binding protein 3Affinity Capture-MSBioGRID16407974 
TCF12HEB | HTF4 | HsT17266 | bHLHb20transcription factor 12Affinity Capture-MSBioGRID16407974 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD8159721|9507011 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)Affinity Capture-MS
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID8159721 |16407974 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4Affinity Capture-MS
Reconstituted Complex
Two-hybrid		BioGRID8576241 |9242638 
|16407974 
TOP1TOPItopoisomerase (DNA) IAffinity Capture-MSBioGRID16407974 
TRRAPFLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1transformation/transcription domain-associated proteinAffinity Capture-MSBioGRID16407974 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6Affinity Capture-MSBioGRID16407974 
ZHX1-zinc fingers and homeoboxes 1-HPRD15383276 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 8659All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP 5534All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
ZIRN TRETINOIN RESPONSE WT1 UP 2314All SZGR 2.0 genes in this pathway
ZIRN TRETINOIN RESPONSE UP 2113All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA 7038All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179105All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 9 1913All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 6648All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 6844All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 7856All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN 3929All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 DN 4331All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS DN 6147All SZGR 2.0 genes in this pathway
LIU SMARCA4 TARGETS 6439All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 7142All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 6344All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 7 2816All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 8 2617All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 8050All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3K27ME3 4130All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway