Gene Page: ZEB1

Summary
GeneID  6935
Symbol  ZEB1
Synonyms  AREB6|BZP|DELTA-EF1|MGC133261|NIL-2-A|NIL-2A|NIL2A|TCF8|ZEB|ZFHEP|ZFHX1A
Description  zinc finger E-box binding homeobox 1
See related  HGNC:11642|MIM:189909|Ensembl:ENSG00000148516|HPRD:01798|
Locus tag  RP11-472N13.4
Gene type  protein-coding
Map location  10p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityTAS8138542 
GO:0003713transcription coactivator activityTAS8138542 
GO:0003714transcription corepressor activityTAS8138542 
GO:0008270zinc ion bindingIEA-
GO:0008270zinc ion bindingTAS8138542 
GO:0008134transcription factor bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentIEABrain (GO term level: 6)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS1840704 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0008283cell proliferationTAS1840704 
GO:0006955immune responseTAS1840704 
GO:0048598embryonic morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005667transcription factor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)TCF8 (deltaEF1) interacts with the CDH1 (E-cadherin) promoter.BIND15674322 
CTBP1BARS | MGC104684C-terminal binding protein 1Affinity Capture-WesternBioGRID10359772 
CTBP2-C-terminal binding protein 2-HPRD9724649 
Affinity Capture-WesternBioGRID10359772 
DRAP1NC2-alphaDR1-associated protein 1 (negative cofactor 2 alpha)-HPRD,BioGRID9418848 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5-HPRD,BioGRID11275565 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1Affinity Capture-WesternBioGRID12743038 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID12743038 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID12743038 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ILK_PATHWAY 4532All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP 6938All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN 5036All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_UP 8557All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_DN 8253All SZGR genes in this pathway
XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR 198All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_HELA 6043All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_DN 7657All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
BAUS_TFF2_TARGETS_UP 3222All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/3014995051Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-3p5015071Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1504114181A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-200bc/4293683751A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-23485491m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3234854911Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3424874931Ahsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-369-3p370376m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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