Gene Page: TEC

Summary ?
GeneID7006
SymbolTEC
SynonymsPSCTK4
Descriptiontec protein tyrosine kinase
ReferenceMIM:600583|HGNC:HGNC:11719|Ensembl:ENSG00000135605|HPRD:02786|Vega:OTTHUMG00000128623
Gene typeprotein-coding
Map location4p12
Pascal p-value0.217
Fetal beta-0.048

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PTPRB0.840.88
COBLL10.820.88
GBP40.800.84
ABCB10.800.82
GPR1160.800.86
FLT10.790.84
A2M0.790.81
CCND10.790.88
ITIH50.790.85
SLCO2B10.790.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SNHG12-0.52-0.60
COMMD3-0.50-0.52
EXOSC8-0.49-0.54
ZNF32-0.49-0.54
NDUFAF2-0.48-0.53
RPL27-0.48-0.60
RPL31-0.48-0.59
SCNM1-0.48-0.50
RPS23-0.47-0.58
RPS27A-0.47-0.61

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF12DKFZp686O2372 | KIAA0382 | LARG | PRO2792Rho guanine nucleotide exchange factor (GEF) 12Biochemical Activity
Phenotypic Enhancement		BioGRID12515866 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID11071635 |11825908 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12-HPRD,BioGRID12515866 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13Phenotypic EnhancementBioGRID12515866 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID9178903 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID9473212 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID7526158 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologAffinity Capture-WesternBioGRID11071635 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Two-hybridBioGRID9178903 
PIK3R3DKFZp686P05226 | FLJ41892 | p55 | p55-GAMMAphosphoinositide-3-kinase, regulatory subunit 3 (gamma)-HPRD9178903 
PLK4SAK | STK18polo-like kinase 4 (Drosophila)-HPRD11489907 
PRLRhPRLrIprolactin receptor-HPRD,BioGRID11328862 
PTPN21PTPD1 | PTPRL10protein tyrosine phosphatase, non-receptor type 21-HPRD11013262 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Phenotypic EnhancementBioGRID11328862 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member AReconstituted ComplexBioGRID12515866 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID9341160 
STAP1BRDG1 | STAP-1signal transducing adaptor family member 1-HPRD10518561 |11716489 
VAV1VAVvav 1 guanine nucleotide exchange factorAffinity Capture-WesternBioGRID11328862 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD7651724 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID8892607 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
PID EPO PATHWAY 3429All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 7859All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING 4334All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 11878All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 5635All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS STIMULATED DN 119All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 7548All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway