SZGR2

Summary ?

GeneID	7014
Symbol	TERF2
Synonyms	TRBF2\|TRF2
Description	telomeric repeat binding factor 2
Reference	MIM:602027\|HGNC:HGNC:11729\|Ensembl:ENSG00000132604\|HPRD:03610\|Vega:OTTHUMG00000137566
Gene type	protein-coding
Map location	16q22.1
Pascal p-value	6.613E-4
Sherlock p-value	0.034
Fetal beta	0.339
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs36781	chr5	109289728	TERF2	7014		0.08		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GPR124	0.66	0.70
SLC2A1	0.65	0.75
BGN	0.65	0.67
MMRN2	0.64	0.71
FGD5	0.64	0.71
OLFML2A	0.63	0.71
COL18A1	0.63	0.65
VWF	0.62	0.69
PLOD1	0.61	0.68
FOXF2	0.61	0.68

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC090186.1	-0.49	-0.55
C8orf59	-0.49	-0.58
ZBTB8OS	-0.48	-0.52
RP9P	-0.45	-0.53
NOX1	-0.43	-0.46
MRPS18C	-0.43	-0.45
ATP5E	-0.42	-0.54
UQCRB	-0.42	-0.46
SYCP3	-0.42	-0.44
C14orf156	-0.41	-0.44

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BLM	BS \| MGC126616 \| MGC131618 \| MGC131620 \| RECQ2 \| RECQL2 \| RECQL3	Bloom syndrome	-	HPRD,BioGRID	12181313
BLM	BS \| MGC126616 \| MGC131618 \| MGC131620 \| RECQ2 \| RECQL2 \| RECQL3	Bloom syndrome	BLM interacts with TRF2.	BIND	12181313
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	CK2-beta interacts with TAF7 promoter.	BIND	15893730
MRE11A	ATLD \| HNGS1 \| MRE11 \| MRE11B	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	Affinity Capture-Western	BioGRID	10888888
NBN	AT-V1 \| AT-V2 \| ATV \| FLJ10155 \| MGC87362 \| NBS \| NBS1 \| P95	nibrin	-	HPRD,BioGRID	10888888
RAD50	RAD50-2 \| hRad50	RAD50 homolog (S. cerevisiae)	-	HPRD,BioGRID	10888888
SUB1	MGC102747 \| P15 \| PC4 \| p14	SUB1 homolog (S. cerevisiae)	PC4 interacts with TAF7 promoter.	BIND	15893730
TERF2	TRBF2 \| TRF2	telomeric repeat binding factor 2	-	HPRD	11545737
TERF2IP	DRIP5 \| RAP1	telomeric repeat binding factor 2, interacting protein	-	HPRD	10850490 \|14565979 \|15100233
TERF2IP	DRIP5 \| RAP1	telomeric repeat binding factor 2, interacting protein	Affinity Capture-MS Affinity Capture-Western Two-hybrid	BioGRID	10850490 \|10888888 \|15100233
TERF2IP	DRIP5 \| RAP1	telomeric repeat binding factor 2, interacting protein	hRap1 interacts with TRF2.	BIND	15316005
TINF2	TERF2 \| TIN2 \| TIN2L	TERF1 (TRF1)-interacting nuclear factor 2	Affinity Capture-MS	BioGRID	15181449
TINF2	TERF2 \| TIN2 \| TIN2L	TERF1 (TRF1)-interacting nuclear factor 2	TIN2 interacts with TRF2.	BIND	15316005
TINF2	TERF2 \| TIN2 \| TIN2L	TERF1 (TRF1)-interacting nuclear factor 2	-	HPRD	15292264
WRN	DKFZp686C2056 \| RECQ3 \| RECQL2 \| RECQL3	Werner syndrome	-	HPRD,BioGRID	12181313
WRN	DKFZp686C2056 \| RECQ3 \| RECQL2 \| RECQL3	Werner syndrome	Wrn interacts with TRF2.	BIND	12181313
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Affinity Capture-Western	BioGRID	15100233
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	-	HPRD,BioGRID	10984620 \|11112778

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID ATM PATHWAY	34	25	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS	116	81	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS	73	57	All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS	48	40	All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE	75	57	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN	126	86	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP	194	112	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION	77	51	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS UP	28	16	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE DN	6	6	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN	42	29	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway

Gene Page: TERF2