Summary ?
GeneID7024
SymbolTFCP2
SynonymsLBP1C|LSF|LSF1D|SEF|TFCP2C
Descriptiontranscription factor CP2
ReferenceMIM:189889|HGNC:HGNC:11748|Ensembl:ENSG00000135457|HPRD:01790|Vega:OTTHUMG00000169621
Gene typeprotein-coding
Map location12q13
Pascal p-value0.393
Sherlock p-value0.925
Fetal beta0.065
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg209270591251567112TFCP2-0.0270.26DMG:Nishioka_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12304878chr1251353850TFCP270241.676E-5cis
rs12304921chr1251357541TFCP270247.043E-4cis
rs224446chr1251381717TFCP270241.917E-5cis
rs2018022chr1251475352TFCP270240.01cis
rs3751275chr1251518786TFCP270247.568E-4cis
rs12304878chr1251353850TFCP270240trans
rs12304921chr1251357541TFCP270240.05trans
rs224446chr1251381717TFCP270240trans
rs3751275chr1251518786TFCP270240.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
STRN40.900.93
KLHL220.890.90
ZMYND190.890.90
DTX30.880.90
RANBP30.880.89
CXXC10.880.90
ZNF5130.870.89
NLE10.870.87
EVL0.870.90
RIC8A0.870.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.77-0.81
MT-CO2-0.77-0.81
AF347015.27-0.75-0.81
AF347015.8-0.74-0.79
MT-CYB-0.74-0.79
AF347015.21-0.73-0.83
AF347015.33-0.73-0.78
AF347015.2-0.71-0.79
AF347015.15-0.71-0.78
AF347015.26-0.68-0.75

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 7451All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR DN 4731All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING DN 4226All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway