SZGR2

Summary ?

GeneID	7048
Symbol	TGFBR2
Synonyms	AAT3\|FAA3\|LDS1B\|LDS2\|LDS2B\|MFS2\|RIIC\|TAAD2\|TGFR-2\|TGFbeta-RII
Description	transforming growth factor beta receptor II
Reference	MIM:190182\|HGNC:HGNC:11773\|Ensembl:ENSG00000163513\|HPRD:01823\|Vega:OTTHUMG00000130569
Gene type	protein-coding
Map location	3p22
Pascal p-value	0.669
Fetal beta	-0.929

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
INSR	0.90	0.91
BACH2	0.89	0.88
SYT6	0.88	0.91
LZTS1	0.88	0.91
ZNF462	0.88	0.84
SRGAP1	0.87	0.80
PLXNA2	0.87	0.89
RRP1B	0.87	0.90
SRGAP2	0.87	0.91
SLC22A23	0.87	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.61	-0.82
SERPINB6	-0.60	-0.67
HSD17B14	-0.60	-0.75
MT-CO2	-0.60	-0.82
C5orf53	-0.59	-0.69
FXYD1	-0.59	-0.81
AIFM3	-0.59	-0.71
AF347015.27	-0.58	-0.78
S100B	-0.58	-0.77
AF347015.33	-0.58	-0.77

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IEA		-
GO:0005024	transforming growth factor beta receptor activity	IDA		7852346 \|18453574
GO:0004872	receptor activity	IEA		-
GO:0004702	receptor signaling protein serine/threonine kinase activity	IEA		-
GO:0005539	glycosaminoglycan binding	IDA		7852346
GO:0005515	protein binding	IPI		8242742
GO:0005524	ATP binding	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0030145	manganese ion binding	IEA		-
GO:0050431	transforming growth factor beta binding	IDA		7852346 \|18243111 \|18453574
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007420	brain development	ISS	Brain (GO term level: 7)	-
GO:0043011	myeloid dendritic cell differentiation	ISS	dendrite (GO term level: 10)	-
GO:0001570	vasculogenesis	ISS		-
GO:0001569	patterning of blood vessels	ISS		-
GO:0001568	blood vessel development	TAS		10092230
GO:0002651	positive regulation of tolerance induction to self antigen	ISS		-
GO:0002663	positive regulation of B cell tolerance induction	ISS		-
GO:0002666	positive regulation of T cell tolerance induction	ISS		-
GO:0002053	positive regulation of mesenchymal cell proliferation	ISS		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007179	transforming growth factor beta receptor signaling pathway	IDA		18453574
GO:0007507	heart development	ISS		-
GO:0051138	positive regulation of NK T cell differentiation	ISS		-
GO:0048701	embryonic cranial skeleton morphogenesis	ISS		-
GO:0032147	activation of protein kinase activity	ISS		-
GO:0035162	embryonic hemopoiesis	ISS		-
GO:0060021	palate development	ISS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0043235	receptor complex	IDA	Neurotransmitter (GO term level: 4)	8774881
GO:0016021	integral to membrane	IEA		-
GO:0009897	external side of plasma membrane	IDA		18453574
GO:0005886	plasma membrane	EXP		9865696 \|11100470

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACVRL1	ACVRLK1 \| ALK-1 \| ALK1 \| HHT \| HHT2 \| ORW2 \| SKR3 \| TSR-I	activin A receptor type II-like 1	-	HPRD	10716993
AP2B1	ADTB2 \| AP105B \| AP2-BETA \| CLAPB1 \| DKFZp781K0743	adaptor-related protein complex 2, beta 1 subunit	Affinity Capture-Western Two-hybrid	BioGRID	12429842
ARHGEF6	COOL2 \| Cool-2 \| KIAA0006 \| MRX46 \| PIXA \| alpha-PIX \| alphaPIX	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	T-beta-RII interacts with alpha-PIX. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse alpha-PIX.	BIND	15761153
ARHGEF7	BETA-PIX \| COOL1 \| DKFZp686C12170 \| DKFZp761K1021 \| KIAA0142 \| KIAA0412 \| Nbla10314 \| P50 \| P50BP \| P85 \| P85COOL1 \| P85SPR \| PAK3 \| PIXB	Rho guanine nucleotide exchange factor (GEF) 7	T-beta-RII interacts with Beta-PIX. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse Beta-PIX.	BIND	15761153
CCNB1	CCNB	cyclin B1	-	HPRD,BioGRID	9926943
CCNB2	HsT17299	cyclin B2	-	HPRD,BioGRID	9926943
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	-	HPRD	12145287
CLU	AAG4 \| APOJ \| CLI \| KUB1 \| MGC24903 \| SGP-2 \| SGP2 \| SP-40 \| TRPM-2 \| TRPM2	clusterin	-	HPRD,BioGRID	8555189
CLU	AAG4 \| APOJ \| CLI \| KUB1 \| MGC24903 \| SGP-2 \| SGP2 \| SP-40 \| TRPM-2 \| TRPM2	clusterin	ApoJ interacts with TGFBR2.	BIND	8555189
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	12000714
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	-	HPRD,BioGRID	11387212
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	-	HPRD	11483955
EIF3I	EIF3S2 \| PRO2242 \| TRIP-1 \| TRIP1 \| eIF3-beta \| eIF3-p36	eukaryotic translation initiation factor 3, subunit I	-	HPRD	7566156 \|11781097
ENG	CD105 \| END \| FLJ41744 \| HHT1 \| ORW \| ORW1	endoglin	-	HPRD,BioGRID	9872992
FLI1	EWSR2 \| SIC-1	Friend leukemia virus integration 1	FLI1 (EWS-FLI1) interacts with the TGFBR2 promoter.	BIND	15735734
KCNK18	K2p18.1 \| TRESK \| TRESK-2 \| TRESK2 \| TRIK	potassium channel, subfamily K, member 18	T-beta-RII interacts with TRIK. This interaction was modeled on a demonstrated interaction between human T-beta-RII and TRIK from an unspecified species.	BIND	15761153
OSR1	ODD	odd-skipped related 1 (Drosophila)	T-beta-RII interacts with OSR1. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse OSR1.	BIND	15761153
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	T-beta-RII interacts with PAK1. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PAK1.	BIND	15761153
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Affinity Capture-Western	BioGRID	9435577
PIK3R2	P85B \| p85 \| p85-BETA	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	Affinity Capture-Western	BioGRID	9435577
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	cPML interacts with T-beta-RII.	BIND	15356634
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD	15356634
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	T-beta-RII interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PPP1C.	BIND	15761153
SCRIB	CRIB1 \| SCRB1 \| SCRIB1 \| Vartul	scribbled homolog (Drosophila)	T-beta-RII interacts with an unspecified isoform of CRIB. This was modeled interaction on a demonstrated interaction between human T-beta-RII and mouse CRIB.	BIND	15761153
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	T-beta-RII phosphorylates hMAD-3. This interaction was modeled on a demonstrated interaction between T-beta-RII from an unspecified species and human hMAD-3.	BIND	8774881
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	T-beta-RII phosphorylates hMAD-4. This interaction was modeled on a demonstrated interaction between T-beta-RII from an unspecified species and human hMAD-4.	BIND	8774881
SMAD7	CRCS3 \| FLJ16482 \| MADH7 \| MADH8	SMAD family member 7	-	HPRD,BioGRID	11163210
SMURF2	DKFZp686F0270 \| MGC138150	SMAD specific E3 ubiquitin protein ligase 2	Affinity Capture-Western	BioGRID	11163210
SNX6	MGC3157 \| MSTP010 \| TFAF2	sorting nexin 6	-	HPRD,BioGRID	11279102
STRAP	MAWD \| PT-WD \| UNRIP	serine/threonine kinase receptor associated protein	-	HPRD,BioGRID	9856985
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	Affinity Capture-Western	BioGRID	11157754
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	-	HPRD	7935686
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	TGF-beta-1 interacts with TGF-beta-R-II. This interaction was modeled on a demonstrated interaction between TGF-beta-1 from an unspecified species and human TGF-beta-R-II.	BIND	7852346
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	-	HPRD	12421567
TGFB2	MGC116892 \| TGF-beta2	transforming growth factor, beta 2	-	HPRD,BioGRID	8106553\|11157754
TGFB3	ARVD \| FLJ16571 \| TGF-beta3	transforming growth factor, beta 3	-	HPRD	8106553 \|11382746 \|11850637 \|12729750
TGFB3	ARVD \| FLJ16571 \| TGF-beta3	transforming growth factor, beta 3	Affinity Capture-Western Co-crystal Structure Reconstituted Complex	BioGRID	9872992 \|11157754 \|11850637 \|12729750
TGFB3	ARVD \| FLJ16571 \| TGF-beta3	transforming growth factor, beta 3	TGF-beta-3 interacts with TGF-beta-R-II. This interaction was modeled on a demonstrated interaction between TGF-beta-3 from an unspecified species and human TGF-beta-R-II.	BIND	7852346
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	-	HPRD,BioGRID	7890683
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	T-beta-R1 interacts with T-beta-R2. This interaction was modeled on a demonstrated interaction between mouse T-beta-R1 and mouse T-beta-R2.	BIND	14612425
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa)	-	HPRD,BioGRID	7890683
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa)	T-beta-RII autophosphorylates. This interaction was modeled on a demonstrated interaction of T-beta-RII from an unspecified species.	BIND	8774881
TGFBR3	BGCAN \| betaglycan	transforming growth factor, beta receptor III	Affinity Capture-Western	BioGRID	8106553
TGFBR3	BGCAN \| betaglycan	transforming growth factor, beta receptor III	-	HPRD	11323414
TGFBRAP1	TRAP-1 \| TRAP1	transforming growth factor, beta receptor associated protein 1	-	HPRD	11278302
TSSK1B	FKSG81 \| SPOGA4 \| STK22D \| TSSK1	testis-specific serine kinase 1B	T-beta-RII interacts with STK22D. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse STK22D.	BIND	15761153
ZFYVE9	MADHIP \| NSP \| SARA \| SMADIP	zinc finger, FYVE domain containing 9	-	HPRD	9865696

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY	37	29	All SZGR 2.0 genes in this pathway
BIOCARTA CTCF PATHWAY	23	18	All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY	21	14	All SZGR 2.0 genes in this pathway
BIOCARTA TGFB PATHWAY	19	14	All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY	27	20	All SZGR 2.0 genes in this pathway
PID INTEGRIN3 PATHWAY	43	25	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	7	All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	23	13	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	26	16	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN	158	102	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN	209	122	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER	22	19	All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS UP	24	17	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS DN	124	79	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN	51	42	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM3	70	37	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP	47	38	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN	26	19	All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR DN	46	34	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN	38	25	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP	126	84	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN UP	19	12	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN	123	86	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D6	37	25	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5	46	36	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6	91	44	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN T LYMPHOCYTE DN	37	29	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN	105	63	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP	170	107	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN	97	53	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL CARCINOMA VS ADENOMA DN	24	18	All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE UP	81	53	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY	32	20	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP	108	78	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE DN	8	7	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND HD MTX DN	25	18	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP	89	61	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
KIM GLIS2 TARGETS UP	84	61	All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP	121	70	All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP	364	236	All SZGR 2.0 genes in this pathway
LOPEZ TRANSLATION VIA FN1 SIGNALING	35	21	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN	418	245	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	266	272	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p	270	276	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-145	2194	2201	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-153	2439	2445	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	268	275	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-186	2338	2344	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-19	265	271	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	265	271	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-204/211	2324	2331	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	2324	2331	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-21	206	212	m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	206	212	m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-219	474	481	1A,m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-23	2383	2390	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	2383	2390	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-320	1762	1768	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	2383	2389	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-370	62	69	1A,m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-378	227	233	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-410	310	316	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-9	47	54	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: TGFBR2