SZGR2

Summary ?

GeneID	71
Symbol	ACTG1
Synonyms	ACT\|ACTG\|BRWS2\|DFNA20\|DFNA26\|HEL-176
Description	actin gamma 1
Reference	MIM:102560\|HGNC:HGNC:144\|Ensembl:ENSG00000184009\|HPRD:00017\|Vega:OTTHUMG00000177955
Gene type	protein-coding
Map location	17q25
Pascal p-value	0.006
Sherlock p-value	0.996
DEG p-value	DEG:Sanders_2014:DS1_p=0.142:DS1_beta=0.049700:DS2_p=8.57e-01:DS2_beta=0.009:DS2_FDR=9.36e-01
Fetal beta	1.813
Support	STRUCTURAL PLASTICITY

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Sanders_2013	Microarray	Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.083

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0005200	structural constituent of cytoskeleton	IC		16130169
GO:0042802	identical protein binding	IPI		16189514
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007605	sensory perception of sound	IEA		-
GO:0006928	cell motion	TAS		16130169
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005856	cytoskeleton	TAS		16130169
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	Two-hybrid	BioGRID	16189514
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	Two-hybrid	BioGRID	16189514
ANXA5	ANX5 \| ENX2 \| PP4	annexin A5	-	HPRD	10903505
BCAP31	6C6-AG \| BAP31 \| CDM \| DXS1357E	B-cell receptor-associated protein 31	-	HPRD,BioGRID	10958671
CAP1	CAP \| CAP1-PEN	CAP, adenylate cyclase-associated protein 1 (yeast)	Affinity Capture-Western Two-hybrid	BioGRID	8761950
CAP2	-	CAP, adenylate cyclase-associated protein, 2 (yeast)	-	HPRD,BioGRID	8761950
CAPZA3	CAPPA3 \| Gsg3	capping protein (actin filament) muscle Z-line, alpha 3	-	HPRD	12029070
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western	BioGRID	9535896
CFL1	CFL	cofilin 1 (non-muscle)	Two-hybrid	BioGRID	16189514
CFL2	NEM7	cofilin 2 (muscle)	Affinity Capture-Western Two-hybrid	BioGRID	16189514
CTNND1	CAS \| CTNND \| KIAA0384 \| P120CAS \| P120CTN \| p120	catenin (cadherin-associated protein), delta 1	Affinity Capture-Western	BioGRID	12835311
DNASE1	DKFZp686H0155 \| DNL1 \| DRNI \| FLJ38093 \| FLJ44902	deoxyribonuclease I	-	HPRD	11474115
DSTN	ACTDP \| ADF \| bA462D18.2	destrin (actin depolymerizing factor)	-	HPRD	8399167
DSTN	ACTDP \| ADF \| bA462D18.2	destrin (actin depolymerizing factor)	Two-hybrid	BioGRID	16189514
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	-	HPRD	14760703
EIF6	2 \| CAB \| EIF3A \| ITGB4BP \| b \| b(2)gcn \| gcn \| p27BBP	eukaryotic translation initiation factor 6	Two-hybrid	BioGRID	16169070
EPS8L1	DRC3 \| EPS8R1 \| FLJ20258 \| MGC23164 \| MGC4642 \| PP10566	EPS8-like 1	Affinity Capture-Western	BioGRID	14565974
EPS8L2	EPS8R2 \| FLJ16738 \| FLJ21935 \| FLJ22171 \| MGC126530 \| MGC3088	EPS8-like 2	Affinity Capture-Western	BioGRID	14565974
EPS8L3	EPS8R3 \| FLJ21522 \| MGC16817	EPS8-like 3	Affinity Capture-Western	BioGRID	14565974
FEZ1	-	fasciculation and elongation protein zeta 1 (zygin I)	Affinity Capture-Western	BioGRID	12874605
FHOD1	FHOS	formin homology 2 domain containing 1	Affinity Capture-Western	BioGRID	14576350
LGALS13	GAL13 \| PLAC8 \| PP13	lectin, galactoside-binding, soluble, 13	-	HPRD	15009185
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
MDK	FLJ27379 \| MK \| NEGF2	midkine (neurite growth-promoting factor 2)	Affinity Capture-MS	BioGRID	10772929
MYO1A	BBMI \| DFNA48 \| MIHC \| MYHL	myosin IA	-	HPRD	11474115
PFN2	D3S1319E \| PFL	profilin 2	Two-hybrid	BioGRID	16169070
PLG	DKFZp779M0222	plasminogen	PLG interacts with ACTG1 (G-actin). This interaction was modelled on a demonstrated interaction between human PLG and bovine ACTG1.	BIND	15746964
PPP1R9A	FLJ20068 \| KIAA1222 \| NRB1 \| NRBI \| Neurabin-I	protein phosphatase 1, regulatory (inhibitor) subunit 9A	-	HPRD	9362513 \|12052877
PRSS23	MGC5107 \| SIG13 \| SPUVE \| ZSIG13	protease, serine, 23	Two-hybrid	BioGRID	16169070
RBX1	BA554C12.1 \| MGC13357 \| MGC1481 \| RNF75 \| ROC1	ring-box 1	Affinity Capture-MS	BioGRID	12481031
SCIN	KIAA1905	scinderin	-	HPRD	1331119
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	Two-hybrid	BioGRID	16169070
ST3GAL3	SIAT6 \| ST3GALII \| ST3GalIII \| ST3N	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Two-hybrid	BioGRID	16169070
TMSB4X	FX \| PTMB4 \| TB4X \| TMSB4	thymosin beta 4, X-linked	-	HPRD	8617195 \|8630056 \|9153421 \|10848969 \|15163409
TMSB4X	FX \| PTMB4 \| TB4X \| TMSB4	thymosin beta 4, X-linked	Co-crystal Structure Reconstituted Complex	BioGRID	8617195 \|15163409
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	WAVE-1 interacts with G-actin. This interaction was modeled on a demonstrated interaction between human WAVE-1 and rat G-actin.	BIND	10970852

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG VIBRIO CHOLERAE INFECTION	56	32	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC	76	59	All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY	92	68	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	35	25	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN	73	51	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC UP	54	30	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP	61	40	All SZGR 2.0 genes in this pathway
CHEN LUNG CANCER SURVIVAL	28	22	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP	62	35	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL	35	25	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN	91	64	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
MMS MOUSE LYMPH HIGH 4HRS UP	36	20	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
WENG POR DOSAGE	21	9	All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER UP	41	29	All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN	49	34	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN DN	18	16	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
WIERENGA PML INTERACTOME	42	23	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2	73	37	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	358	364	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	358	364	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-103/107	26	32	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	26	32	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-145	96	103	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-186	610	616	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-199	151	157	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	151	157	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-361	140	146	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-381	184	190	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	184	190	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-485-5p	86	92	1A	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ACTG1