Summary ?
GeneID7137
SymbolTNNI3
SynonymsCMD1FF|CMD2A|CMH7|RCM1|TNNC1|cTnI
Descriptiontroponin I3, cardiac type
ReferenceMIM:191044|HGNC:HGNC:11947|Ensembl:ENSG00000129991|HPRD:11769|Vega:OTTHUMG00000180589
Gene typeprotein-coding
Map location19q13.4
Pascal p-value0.009
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIDA10806205 
GO:0048306calcium-dependent protein bindingIPI7957210 
GO:0019855calcium channel inhibitor activityIPI12809519 
GO:0030172troponin C bindingIPI7957210 |11735257 |15542288 
GO:0019904protein domain specific bindingIPI11984006 
GO:0031014troponin T bindingIPI15542288 
GO:0019901protein kinase bindingIPI12721663 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001980regulation of systemic arterial blood pressure by ischemic conditionsISSBrain (GO term level: 9)-
GO:0001570vasculogenesisISS-
GO:0055010ventricular cardiac muscle morphogenesisIMP11815426 
GO:0007507heart developmentISS-
GO:0006937regulation of muscle contractionIEA-
GO:0006874cellular calcium ion homeostasisISS-
GO:0032780negative regulation of ATPase activityIDA7957210 |11735257 
GO:0032780negative regulation of ATPase activityIMP10806205 
GO:0060048cardiac muscle contractionIMP11735257 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005861troponin complexIDA7957210 |10806205 |10850966 
|12093807 
GO:0030017sarcomereIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CARDIAC MUSCLE CONTRACTION 8051All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 8565All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 9268All SZGR 2.0 genes in this pathway
REACTOME STRIATED MUSCLE CONTRACTION 2712All SZGR 2.0 genes in this pathway
REACTOME MUSCLE CONTRACTION 4824All SZGR 2.0 genes in this pathway
PIEPOLI LGI1 TARGETS DN 146All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3 4831All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234137All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 9164All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 12893All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 8050All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271165All SZGR 2.0 genes in this pathway