Gene Page: TNNT1

Summary ?
GeneID7138
SymbolTNNT1
SynonymsANM|NEM5|STNT|TNT|TNTS
Descriptiontroponin T1, slow skeletal type
ReferenceMIM:191041|HGNC:HGNC:11948|Ensembl:ENSG00000105048|HPRD:01841|Vega:OTTHUMG00000180542
Gene typeprotein-coding
Map location19q13.4
Pascal p-value0.009
Sherlock p-value0.893
Fetal beta-2.257
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg193937621955661872TNNT13.61E-6-0.4460.009DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7258577chr1955186254TNNT171380.16cis
rs17714747chr2205010190TNNT171380.15trans
rs9313483chr5169448229TNNT171380.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PRPF390.870.89
PEX10.870.88
CCDC820.860.84
WDR750.860.86
SLC35A10.850.84
TUBE10.850.82
SMC60.850.85
MFN10.840.84
ZNF1870.840.86
UTP60.840.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.65-0.74
AF347015.31-0.65-0.75
AF347015.27-0.64-0.72
MT-CYB-0.63-0.73
AF347015.8-0.63-0.74
HLA-F-0.62-0.66
AF347015.33-0.62-0.71
AF347015.15-0.61-0.73
IFI27-0.61-0.73
AF347015.2-0.60-0.74

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
PLEKHF1APPD | MGC4090 | PHAFIN1 | ZFYVE15pleckstrin homology domain containing, family F (with FYVE domain) member 1Two-hybridBioGRID16189514 
PPFIA1FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1Two-hybridBioGRID16189514 
PRKG1CGKI | DKFZp686K042 | FLJ36117 | MGC71944 | PGK | PKG | PRKG1B | PRKGR1B | cGKI-BETA | cGKI-alphaprotein kinase, cGMP-dependent, type IAffinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID10601315 
PSMC5S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUGproteasome (prosome, macropain) 26S subunit, ATPase, 5Two-hybridBioGRID16189514 
RP4-691N24.1FLJ11792 | KIAA0980 | NLP | dJ691N24.1ninein-likeTwo-hybridBioGRID16189514 
TNNC1CMD1Z | TNC | TNNCtroponin C type 1 (slow)Two-hybridBioGRID9448267 
TNNI3CMD2A | CMH7 | MGC116817 | TNNC1 | cTnItroponin I type 3 (cardiac)-HPRD11904166 
TNNT1ANM | FLJ98147 | MGC104241 | STNT | TNT | TNTStroponin T type 1 (skeletal, slow)Two-hybridBioGRID16189514 
TPM1C15orf13 | CMD1Y | HTM-alpha | TMSAtropomyosin 1 (alpha)Reconstituted ComplexBioGRID6822572 
ZMYND19MIZIP | RP11-48C7.4zinc finger, MYND-type containing 19Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME STRIATED MUSCLE CONTRACTION 2712All SZGR 2.0 genes in this pathway
REACTOME MUSCLE CONTRACTION 4824All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 11272All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 11866All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 8960All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM UP 3830All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 8251All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 12860All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 8956All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 2515All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266142All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 3516All SZGR 2.0 genes in this pathway