SZGR2

Summary ?

GeneID	7158
Symbol	TP53BP1
Synonyms	53BP1\|TDRD30\|TP53\|p202\|p53BP1
Description	tumor protein p53 binding protein 1
Reference	MIM:605230\|HGNC:HGNC:11999\|Ensembl:ENSG00000067369\|HPRD:05569\|Vega:OTTHUMG00000059757
Gene type	protein-coding
Map location	15q15-q21
Pascal p-value	4.038E-4
Sherlock p-value	0.038
Fetal beta	0.318
Support	G2Cdb.humanNRC G2Cdb.humanPSP Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
OCM	0.60	0.33
IGSF10	0.54	0.61
TACR3	0.54	0.53
ARHGAP6	0.53	0.30
ODZ1	0.48	0.68
LUZP2	0.48	0.52
SLC41A2	0.47	0.65
RP3-402H5.1	0.47	0.56
SCN9A	0.47	0.65
CSMD3	0.47	0.68

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.26	-0.50
HIGD1B	-0.26	-0.51
AC098691.2	-0.26	-0.49
AF347015.2	-0.26	-0.47
C11orf67	-0.25	-0.45
CSAG1	-0.25	-0.42
MT-CYB	-0.25	-0.47
AF347015.8	-0.24	-0.48
AF347015.33	-0.24	-0.46
AF347015.31	-0.24	-0.47

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATM	AT1 \| ATA \| ATC \| ATD \| ATDC \| ATE \| DKFZp781A0353 \| MGC74674 \| TEL1 \| TELO1	ataxia telangiectasia mutated	Biochemical Activity Reconstituted Complex	BioGRID	12447390 \|12697768
BLM	BS \| MGC126616 \| MGC131618 \| MGC131620 \| RECQ2 \| RECQL2 \| RECQL3	Bloom syndrome	Affinity Capture-Western Co-localization	BioGRID	15364958
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Affinity Capture-Western	BioGRID	17525332
CHEK1	CHK1	CHK1 checkpoint homolog (S. pombe)	Co-localization	BioGRID	15364958
CHEK2	CDS1 \| CHK2 \| HuCds1 \| LFS2 \| PP1425 \| RAD53	CHK2 checkpoint homolog (S. pombe)	Affinity Capture-Western	BioGRID	17525332
DCLRE1A	KIAA0086 \| PSO2 \| SNM1 \| SNM1A \| hSNM1	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)	Affinity Capture-Western	BioGRID	12446782
DCLRE1C	A-SCID \| DCLREC1C \| FLJ11360 \| FLJ36438 \| RS-SCID \| SCIDA \| SNM1C	DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)	Artemis interacts with 53BP1.	BIND	15574327
DCTN1	DAP-150 \| DP-150 \| HMN7B \| P135	dynactin 1 (p150, glued homolog, Drosophila)	Affinity Capture-Western	BioGRID	15611139
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	Affinity Capture-Western Protein-peptide Two-hybrid	BioGRID	15611139
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	8896460
H2AFX	H2A.X \| H2A/X \| H2AX	H2A histone family, member X	-	HPRD,BioGRID	12697768
MDC1	DKFZp781A0122 \| KIAA0170 \| MGC166888 \| NFBD1	mediator of DNA damage checkpoint 1	-	HPRD	12607005
NEK1	DKFZp686D06121 \| DKFZp686K12169 \| KIAA1901 \| MGC138800 \| NY-REN-55	NIMA (never in mitosis gene a)-related kinase 1	NEK1 interacts with 53BP1.	BIND	14690447
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Affinity Capture-Western	BioGRID	10646849
PAXIP1	CAGF28 \| CAGF29 \| FLJ41049 \| PACIP1 \| PAXIP1L \| PTIP \| TNRC2	PAX interacting (with transcription-activation domain) protein 1	Affinity Capture-Western Reconstituted Complex	BioGRID	14576432 \|15456759
RPA1	HSSB \| REPA1 \| RF-A \| RP-A \| RPA70	replication protein A1, 70kDa	Affinity Capture-MS Affinity Capture-Western	BioGRID	15856006
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	Affinity Capture-MS Affinity Capture-Western	BioGRID	15856006
TFDP1	DP1 \| DRTF1 \| Dp-1	transcription factor Dp-1	Reconstituted Complex	BioGRID	8896460
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Affinity Capture-Western Co-crystal Structure Co-localization Reconstituted Complex Two-hybrid	BioGRID	8016121 \|11877378 \|12110597 \|12351827 \|14978302 \|15364958 \|15611139
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD	8016121 \|12110597

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID ATM PATHWAY	34	25	All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	17	11	All SZGR 2.0 genes in this pathway
REACTOME DOUBLE STRAND BREAK REPAIR	24	14	All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR	112	59	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC	44	31	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP	344	180	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP	65	44	All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70	67	33	All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR DN	53	40	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1	237	159	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Gene Page: TP53BP1