Summary ?
GeneID7161
SymbolTP73
SynonymsP73
Descriptiontumor protein p73
ReferenceMIM:601990|HGNC:HGNC:12003|Ensembl:ENSG00000078900|HPRD:03587|Vega:OTTHUMG00000000610
Gene typeprotein-coding
Map location1p36.3
Pascal p-value0.447
Fetal beta0.223
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0413757613575674TP731.767E-4-0.3810.034DMG:Wockner_2014
cg2484567513649971TP732.317E-40.4660.036DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs73705640TP7371610.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZCCHC140.960.97
CAMSAP10.960.98
MAPKBP10.950.96
ADD20.950.97
XXbac-B461K10.10.950.94
SRGAP20.940.97
PPP1R100.940.95
DIP2C0.940.94
USP420.940.96
PIK3C2B0.940.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.74-0.89
S100B-0.74-0.86
TSC22D4-0.74-0.80
FXYD1-0.73-0.86
AF347015.27-0.73-0.86
MT-CO2-0.73-0.88
AIFM3-0.73-0.76
SERPINB6-0.72-0.78
HEPN1-0.72-0.75
AF347015.33-0.72-0.84

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID10391250 |10391251 
BAXBCL2L4BCL2-associated X proteinp73-alpha interacts with BAX promoter.BIND15893728 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3p73-alpha binds p53 AIP1 promoter.BIND15175157 
CABLES1CABLES | FLJ35924 | HsT2563 | IK3-1Cdk5 and Abl enzyme substrate 1-HPRD11706030 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)p73-beta interacts with p21 promoter. This interaction was modeled on a demonstrated interaction between p73-beta from an unspecified species and human p21 promoter.BIND15893728 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)p73-alpha interacts with p21 promoter.BIND15893728 
CEBPZCBF2 | HSP-CBF | NOC1CCAAT/enhancer binding protein (C/EBP), zeta-HPRD,BioGRID12534345 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3-HPRD,BioGRID10961991 
DENND4AFLJ33949 | IRLB | KIAA0476 | MYCPBPDENN/MADD domain containing 4Ap73 alpha interacts with c-Myc.BIND12080043 
EP300KAT3B | p300E1A binding protein p300p73-alpha interacts with p300.This interaction was modeled on a demonstrated interaction between human p73-alpha and p300 from an unspecified species.BIND15175157 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1RACK1 interacts with p73.BIND12761493 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID12761493 
HECW2DKFZp686M17164 | NEDL2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2-HPRD12890487 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD,BioGRID11925430 
HIPK3DYRK6 | FIST3 | PKY | YAK1homeodomain interacting protein kinase 3Two-hybridBioGRID10961991 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1p73alpha interacts with HMGB1.BIND11748232 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1p73-beta interacts with HMGB1.BIND11748232 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1-HPRD,BioGRID11748232 
ITCHAIF4 | AIP4 | NAPP1 | dJ468O1.1itchy E3 ubiquitin protein ligase homolog (mouse)p73-alpha interacts with Itch.BIND15678106 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD,BioGRID10207051 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID12080043 
NEDD4KIAA0093 | MGC176705 | NEDD4-1 | RPF1neural precursor cell expressed, developmentally down-regulated 4p73-alpha interacts with an unspecified isoform of Nedd4.BIND15678106 
NFYBCBF-A | CBF-B | HAP3 | NF-YBnuclear transcription factor Y, beta-HPRD,BioGRID12167641 
NFYCCBF-C | CBFC | DKFZp667G242 | FLJ45775 | H1TF2A | HAP5 | HSM | NF-YCnuclear transcription factor Y, gammaAffinity Capture-WesternBioGRID12167641 
P53AIP1-p53-regulated apoptosis-inducing protein 1p73-alpha interacts with p53AIP1 promoter.BIND15893728 
PFDN5MGC5329 | MGC71907 | MM-1 | MM1 | PFD5prefoldin subunit 5MM1 interacts with p73-alpha.BIND11844794 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1Pin1 interacts with phosphorylated p73-alphaBIND15175157 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1Pin1 interacts with p73-beta.BIND15175157 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD11832207 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Affinity Capture-WesternBioGRID12761493 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Two-hybridBioGRID10961991 
TDG-thymine-DNA glycosylaseTwo-hybridBioGRID10961991 
TP73P73tumor protein p73Two-hybridBioGRID10961991 
TP73P73tumor protein p73p73 alpha interacts with itself.BIND11389695 
TP73P73tumor protein p73p73 splicing variants interact with each other.BIND11389695 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID10961991 
YAP1YAP | YAP2 | YAP65 | YKIYes-associated protein 1, 65kDa-HPRD,BioGRID11278685 
YAP1YAP | YAP2 | YAP65 | YKIYes-associated protein 1, 65kDap73-alpha interacts with YAP.BIND15893728 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG P53 SIGNALING PATHWAY 6945All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
BIOCARTA ATM PATHWAY 2016All SZGR 2.0 genes in this pathway
PID P73PATHWAY 7959All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 14296All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
TURJANSKI MAPK14 TARGETS 1010All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 8864All SZGR 2.0 genes in this pathway
OHM METHYLATED IN ADULT CANCERS 2723All SZGR 2.0 genes in this pathway
OHM EMBRYONIC CARCINOMA DN 86All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 2920All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473224All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER DN 2826All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
LIU TOPBP1 TARGETS 168All SZGR 2.0 genes in this pathway