SZGR2

Summary ?

GeneID	7189
Symbol	TRAF6
Synonyms	MGC:3310\|RNF85
Description	TNF receptor associated factor 6
Reference	MIM:602355\|HGNC:HGNC:12036\|HPRD:03833\|
Gene type	protein-coding
Map location	11p12
Pascal p-value	5.373E-4

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.4462

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		11244088 \|11397809 \|11751921 \|15125833
GO:0004842	ubiquitin-protein ligase activity	IDA		15125833
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0043011	myeloid dendritic cell differentiation	IEA	dendrite (GO term level: 10)	-
GO:0000209	protein polyubiquitination	IDA		15125833
GO:0001503	ossification	IEA		-
GO:0002726	positive regulation of T cell cytokine production	IMP		15125833
GO:0001843	neural tube closure	IEA		-
GO:0006511	ubiquitin-dependent protein catabolic process	IEA		-
GO:0007250	activation of NF-kappaB-inducing kinase activity	IMP		15125833
GO:0009887	organ morphogenesis	IEA		-
GO:0007165	signal transduction	IEA		-
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA		-
GO:0048468	cell development	IEA		-
GO:0006955	immune response	IEA		-
GO:0042981	regulation of apoptosis	IEA		-
GO:0051023	regulation of immunoglobulin secretion	IEA		-
GO:0042475	odontogenesis of dentine-containing tooth	IEA		-
GO:0050852	T cell receptor signaling pathway	IMP		15125833
GO:0050870	positive regulation of T cell activation	IC		15125833
GO:0042088	T-helper 1 type immune response	IEA		-
GO:0032743	positive regulation of interleukin-2 production	IMP		15125833
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP		12761501
GO:0045084	positive regulation of interleukin-12 biosynthetic process	IEA		-
GO:0045410	positive regulation of interleukin-6 biosynthetic process	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9162092 \|9744859 \|10066798 \|10465784 \|12138165 \|12609980 \|15125833
GO:0005829	cytosol	IEA		-
GO:0005624	membrane fraction	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ASXL2	ASXH2 \| DKFZp686C1968 \| FLJ10898 \| KIAA1685	additional sex combs like 2 (Drosophila)	Affinity Capture-MS	BioGRID	17353931
ATP2A2	ATP2B \| DAR \| DD \| DKFZp686P0211 \| FLJ20293 \| FLJ38063 \| MGC45367 \| SERCA2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	-	HPRD	14743216
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	Reconstituted Complex	BioGRID	9384571 \|9990007
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	-	HPRD	10075662 \|10411888
CTPS	-	CTP synthase	Affinity Capture-MS	BioGRID	17353931
DDX3X	DBX \| DDX14 \| DDX3 \| HLP2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	Affinity Capture-MS	BioGRID	17353931
ECSIT	SITPEC	ECSIT homolog (Drosophila)	-	HPRD,BioGRID	10465784
EDA2R	EDA-A2R \| EDAA2R \| TNFRSF27 \| XEDAR	ectodysplasin A2 receptor	-	HPRD,BioGRID	12060722
EIF4E2	4E-LP \| 4EHP \| EIF4EL3 \| IF4e	eukaryotic translation initiation factor 4E family member 2	Affinity Capture-MS	BioGRID	17353931
EPPK1	EPIPL \| EPIPL1	epiplakin 1	Affinity Capture-MS	BioGRID	17353931
GANAB	G2AN \| GluII \| KIAA0088	glucosidase, alpha; neutral AB	Affinity Capture-MS	BioGRID	17353931
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD	14743216
IARS	FLJ20736 \| IARS1 \| ILRS \| PRO0785	isoleucyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931
IL17RB	CRL4 \| EVI27 \| IL17BR \| IL17RH1 \| MGC5245	interleukin 17 receptor B	-	HPRD,BioGRID	10748240
IRAK1	IRAK \| pelle	interleukin-1 receptor-associated kinase 1	TRAF6 interacts with IRAK1. This interaction was modeled on a demonstrated interaction between TRAF6 and IRAK1, both from unspecified species.	BIND	15894263
IRAK1	IRAK \| pelle	interleukin-1 receptor-associated kinase 1	-	HPRD,BioGRID	8837778
IRAK2	IRAK-2 \| MGC150550	interleukin-1 receptor-associated kinase 2	IRAK-2 interacts with TRAF6.	BIND	10383454
IRAK2	IRAK-2 \| MGC150550	interleukin-1 receptor-associated kinase 2	-	HPRD,BioGRID	9374458
IRAK3	ASRT5 \| IRAK-M \| IRAKM	interleukin-1 receptor-associated kinase 3	IRAK-M interacts with TRAF6.	BIND	10383454
IRAK3	ASRT5 \| IRAK-M \| IRAKM	interleukin-1 receptor-associated kinase 3	-	HPRD,BioGRID	10383454
IRAK4	IPD1 \| NY-REN-64 \| REN64	interleukin-1 receptor-associated kinase 4	-	HPRD,BioGRID	11960013
IRF7	IRF-7H \| IRF7A	interferon regulatory factor 7	IRF7 intereacts with TRAF6. This interaction was modeled on a demonstrated interaction between mouse IRF7 and human TRAF6.	BIND	15361868
KCNQ1	ATFB1 \| FLJ26167 \| JLNS1 \| KCNA8 \| KCNA9 \| KVLQT1 \| Kv1.9 \| Kv7.1 \| LQT \| LQT1 \| RWS \| SQT2 \| WRS	potassium voltage-gated channel, KQT-like subfamily, member 1	Affinity Capture-MS	BioGRID	14743216
MALT1	DKFZp434L132 \| MLT \| MLT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	TRAF6 interacts with MALT1. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and MALT1 from human.	BIND	15125833
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	11278268
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	NIK interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human NIK and TRAF6 from an unspecified species.	BIND	9275204
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	10523862
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD,BioGRID	10094049
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	-	HPRD,BioGRID	10094049
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD,BioGRID	10882101
MAP3K7IP3	MGC45404 \| NAP1 \| TAB3	mitogen-activated protein kinase kinase kinase 7 interacting protein 3	TAB3 interacts with TRAF6.	BIND	15327770
MAP3K7IP3	MGC45404 \| NAP1 \| TAB3	mitogen-activated protein kinase kinase kinase 7 interacting protein 3	-	HPRD,BioGRID	14633987
MAST2	FLJ39200 \| KIAA0807 \| MAST205 \| MTSSK \| RP4-533D7.1	microtubule associated serine/threonine kinase 2	-	HPRD,BioGRID	15308666
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	Affinity Capture-MS	BioGRID	17353931
MTHFD1	MTHFC \| MTHFD	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	Affinity Capture-MS	BioGRID	17353931
NASP	DKFZp547F162 \| FLB7527 \| FLJ31599 \| FLJ35510 \| MGC19722 \| MGC20372 \| MGC2297 \| PRO1999	nuclear autoantigenic sperm protein (histone-binding)	Affinity Capture-MS	BioGRID	17353931
NGFR	CD271 \| Gp80-LNGFR \| TNFRSF16 \| p75(NTR) \| p75NTR	nerve growth factor receptor (TNFR superfamily, member 16)	-	HPRD,BioGRID	10514511
NTSR1	NTR	neurotensin receptor 1 (high affinity)	-	HPRD	10514511
OTUD7B	CEZANNE \| ZA20D1	OTU domain containing 7B	-	HPRD,BioGRID	11463333
OTUD7B	CEZANNE \| ZA20D1	OTU domain containing 7B	-	HPRD	9928991
PAICS	ADE2 \| ADE2H1 \| AIRC \| DKFZp781N1372 \| MGC1343 \| MGC5024 \| PAIS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	Affinity Capture-MS	BioGRID	17353931
PELI3	MGC35521	pellino homolog 3 (Drosophila)	-	HPRD	12874243
PFAS	FGAMS \| FGARAT \| KIAA0361 \| PURL	phosphoribosylformylglycinamidine synthase	Affinity Capture-MS	BioGRID	17353931
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	10747026
PSMA4	HC9 \| HsT17706 \| MGC111191 \| MGC12467 \| MGC24813 \| PSC9	proteasome (prosome, macropain) subunit, alpha type, 4	-	HPRD	14743216
PSMB5	LMPX \| MB1 \| MGC104214 \| X	proteasome (prosome, macropain) subunit, beta type, 5	Affinity Capture-MS	BioGRID	14743216
PSMC1	MGC24583 \| MGC8541 \| P26S4 \| S4 \| p56	proteasome (prosome, macropain) 26S subunit, ATPase, 1	Affinity Capture-MS	BioGRID	14743216
PSMC2	MGC3004 \| MSS1 \| Nbla10058 \| S7	proteasome (prosome, macropain) 26S subunit, ATPase, 2	Affinity Capture-MS	BioGRID	14743216
PSMC3	MGC8487 \| TBP1	proteasome (prosome, macropain) 26S subunit, ATPase, 3	Affinity Capture-MS	BioGRID	14743216
PSMD1	MGC133040 \| MGC133041 \| P112 \| Rpn2 \| S1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	-	HPRD,BioGRID	14743216
PSMD12	MGC75406 \| Rpn5 \| p55	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	-	HPRD,BioGRID	14743216
PSMD13	HSPC027 \| Rpn9 \| S11 \| p40.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	Affinity Capture-MS	BioGRID	14743216
PSMD3	P58 \| RPN3 \| S3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	-	HPRD,BioGRID	14743216
PSMD4	AF \| AF-1 \| ASF \| MCB1 \| Rpn10 \| S5A \| pUB-R5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	-	HPRD	14743216
PSMD7	MOV34 \| P40 \| Rpn8 \| S12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	Affinity Capture-MS	BioGRID	14743216
PSMD8	HIP6 \| HYPF \| MGC1660 \| Nin1p \| Rpn12 \| S14 \| p31	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	-	HPRD	14743216
RIPK2	CARD3 \| CARDIAK \| CCK \| GIG30 \| RICK \| RIP2	receptor-interacting serine-threonine kinase 2	-	HPRD,BioGRID	9642260
RNF126	FLJ20552 \| MGC1022 \| MGC14317	ring finger protein 126	-	HPRD	14743216
SIGIRR	MGC110992 \| TIR8	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	-	HPRD,BioGRID	12925853
SPOP	TEF2	speckle-type POZ protein	-	HPRD,BioGRID	11279055
SQSTM1	A170 \| OSIL \| PDB3 \| ZIP3 \| p60 \| p62 \| p62B	sequestosome 1	-	HPRD,BioGRID	10747026 \|11244088
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	10635328
STRADB	ALS2CR2 \| CALS-21 \| ILPIP \| ILPIPA \| MGC102916 \| PAPK \| PRO1038	STE20-related kinase adaptor beta	-	HPRD,BioGRID	12048196
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	11418661
TARS	MGC9344 \| ThrRS	threonyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931
TAX1BP1	CALCOCO3 \| T6BP \| TXBP151	Tax1 (human T-cell leukemia virus type I) binding protein 1	-	HPRD,BioGRID	10920205
TICAM1	MGC35334 \| PRVTIRB \| TICAM-1 \| TRIF	toll-like receptor adaptor molecule 1	TRIF interacts with TRAF6.	BIND	14530355
TICAM1	MGC35334 \| PRVTIRB \| TICAM-1 \| TRIF	toll-like receptor adaptor molecule 1	An unspecified isoform of TRIF interacts with TRAF6. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and TRAF from an unspecified species.	BIND	15474016
TICAM2	MGC129876 \| MGC129877 \| TICAM-2 \| TIRAP3 \| TIRP \| TRAM	toll-like receptor adaptor molecule 2	-	HPRD	12721283
TICAM2	MGC129876 \| MGC129877 \| TICAM-2 \| TIRAP3 \| TIRP \| TRAM	toll-like receptor adaptor molecule 2	TIRP interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human TIRP and TRAF6 from an unspecified species.	BIND	12721283
TIFA	MGC20791 \| T2BP \| T6BP \| TIFAA	TRAF-interacting protein with forkhead-associated domain	-	HPRD,BioGRID	12566447
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	Affinity Capture-MS	BioGRID	17353931
TMEM189-UBE2V1	CROC-1B \| Kua-UEV \| UBE2V1	TMEM189-UBE2V1 readthrough transcript	-	HPRD,BioGRID	11057907
TNFAIP3	A20 \| MGC104522 \| MGC138687 \| MGC138688 \| OTUD7C \| TNFA1P2	tumor necrosis factor, alpha-induced protein 3	-	HPRD,BioGRID	9928991
TNFRSF11A	CD265 \| FEO \| LOH18CR1 \| ODFR \| OFE \| OPTB7 \| OSTS \| PDB2 \| RANK \| TRANCER	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Affinity Capture-Western Reconstituted Complex	BioGRID	9685412 \|9852070 \|10025951 \|10075662 \|11809792
TNFRSF11A	CD265 \| FEO \| LOH18CR1 \| ODFR \| OFE \| OPTB7 \| OSTS \| PDB2 \| RANK \| TRANCER	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	-	HPRD	9685412 \|10025951 \|10075662 \|10635328
TNFRSF13B	CD267 \| CVID \| FLJ39942 \| MGC133214 \| MGC39952 \| TACI \| TNFRSF14B	tumor necrosis factor receptor superfamily, member 13B	-	HPRD,BioGRID	10880535
TNFRSF19	TAJ \| TAJ-alpha \| TRADE \| TROY	tumor necrosis factor receptor superfamily, member 19	-	HPRD,BioGRID	12060722
TNFSF11	CD254 \| ODF \| OPGL \| OPTB2 \| RANKL \| TRANCE \| hRANKL2 \| sOdf	tumor necrosis factor (ligand) superfamily, member 11	-	HPRD	10635328
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	TRAF6 interacts with itself and forms an oligomer.	BIND	15125833
TRIM37	KIAA0898 \| MUL \| POB1 \| TEF3	tripartite motif-containing 37	-	HPRD,BioGRID	11279055
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	-	HPRD,BioGRID	10764746
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14743216
TUBB2B	DKFZp566F223 \| FLJ98847 \| MGC8685 \| TUBB-PARALOG \| bA506K6.1	tubulin, beta 2B	-	HPRD	14743216
UBB	FLJ25987 \| MGC8385	ubiquitin B	TRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source.	BIND	15125833
USP7	HAUSP \| TEF1	ubiquitin specific peptidase 7 (herpes virus-associated)	-	HPRD,BioGRID	11279055
VARS	G7A \| VARS1 \| VARS2	valyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931
VCP	IBMPFD \| MGC131997 \| MGC148092 \| MGC8560 \| TERA \| p97	valosin-containing protein	Affinity Capture-MS	BioGRID	17353931
VDAC1	MGC111064 \| PORIN \| PORIN-31-HL	voltage-dependent anion channel 1	Affinity Capture-MS	BioGRID	17353931
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	-	HPRD,BioGRID	12048196
ZFAND5	ZA20D2 \| ZFAND5A \| ZNF216	zinc finger, AN1-type domain 5	Affinity Capture-Western	BioGRID	14754897
ZFAND5	ZA20D2 \| ZFAND5A \| ZNF216	zinc finger, AN1-type domain 5	ZNF216 interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human ZNF216 and TRAF6 from an unspecified species.	BIND	14754897
ZNF675	FLJ36350 \| TBZF \| TIZ	zinc finger protein 675	-	HPRD,BioGRID	11751921
ZRANB1	DKFZp762P2216 \| TRABID	zinc finger, RAN-binding domain containing 1	-	HPRD,BioGRID	11463333

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY	71	51	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA RELA PATHWAY	16	12	All SZGR 2.0 genes in this pathway
BIOCARTA RANKL PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA CD40 PATHWAY	15	13	All SZGR 2.0 genes in this pathway
BIOCARTA NFKB PATHWAY	23	19	All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY	33	29	All SZGR 2.0 genes in this pathway
BIOCARTA TALL1 PATHWAY	15	15	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID TCR PATHWAY	66	51	All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY	23	20	All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY	31	26	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING	54	46	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING	37	32	All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	12	8	All SZGR 2.0 genes in this pathway
REACTOME REGULATED PROTEOLYSIS OF P75NTR	10	9	All SZGR 2.0 genes in this pathway
REACTOME P75NTR SIGNALS VIA NFKB	14	10	All SZGR 2.0 genes in this pathway
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	15	10	All SZGR 2.0 genes in this pathway
REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	11	8	All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	60	43	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	23	17	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	16	9	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	18	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING	39	30	All SZGR 2.0 genes in this pathway
REACTOME IRAK1 RECRUITS IKK COMPLEX	10	8	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	30	26	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	21	17	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	10	9	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	14	7	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP	276	165	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP	341	197	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS	37	27	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN	156	106	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE DN	11	9	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0	107	72	All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK	75	47	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP	111	68	All SZGR 2.0 genes in this pathway
LEIN CEREBELLUM MARKERS	85	47	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION	81	59	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK UP	22	15	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP	10	7	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN	113	76	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-146	473	480	1A,m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	473	480	1A,m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: TRAF6