Gene Page: TRIP6

Summary ?
GeneID7205
SymbolTRIP6
SynonymsOIP-1|OIP1|TRIP-6|TRIP6i2|ZRP-1
Descriptionthyroid hormone receptor interactor 6
ReferenceMIM:602933|HGNC:HGNC:12311|Ensembl:ENSG00000087077|HPRD:04242|Vega:OTTHUMG00000157029
Gene typeprotein-coding
Map location7q22
Pascal p-value0.002
Sherlock p-value0.635
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0561 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6879593chr575253310TRIP672050.18trans
rs12677010chr872609894TRIP672050.15trans
rs1111195chr1651416325TRIP672050.16trans
rs9944345chr1651419164TRIP672050.16trans
rs11080561chr1812257229TRIP672050.02trans
rs2692986chrX31412008TRIP672050.15trans
rs65275240TRIP672050.17trans
rs4501739chrX35960848TRIP672050.01trans
rs16983508chrX99747940TRIP672050.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C22orf300.940.96
KIAA14090.940.96
KDM2A0.940.96
ZNF3180.930.95
MBD50.930.95
NCOR10.930.94
LYST0.920.94
UBN10.920.94
ATXN70.920.94
ZSCAN290.920.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.73-0.78
MT-CO2-0.71-0.76
HIGD1B-0.71-0.79
AF347015.21-0.70-0.81
FXYD1-0.70-0.74
IFI27-0.69-0.74
CST3-0.69-0.76
HSD17B14-0.68-0.72
S100A16-0.68-0.73
AF347015.27-0.68-0.72

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005149interleukin-1 receptor bindingIDA15657077 
GO:0008270zinc ion bindingIEA-
GO:0019900kinase bindingIPI15657077 
GO:0042802identical protein bindingIPI17353931 
GO:0046872metal ion bindingIEA-
GO:0046966thyroid hormone receptor bindingNAS9598321 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008588release of cytoplasmic sequestered NF-kappaBIDA15657077 
GO:0048041focal adhesion formationNAS14688263 
GO:0030335positive regulation of cell migrationIMP14688263 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005925focal adhesionIDA14688263 
GO:0045323interleukin-1 receptor complexIDA15657077 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscleCo-localizationBioGRID14688263 
AFAP1L1FLJ36748 | MGC149773actin filament associated protein 1-like 1Affinity Capture-MSBioGRID17353931 
AQP1AQP-CHIP | CHIP28 | CO | MGC26324aquaporin 1 (Colton blood group)Two-hybridBioGRID16189514 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID11782456 |14688263 
CATSPER1CATSPER | MGC33335 | MGC33368cation channel, sperm associated 1Two-hybridBioGRID16189514 
FAM124BFLJ22746family with sequence similarity 124BTwo-hybridBioGRID16189514 
FAM46CFLJ20202family with sequence similarity 46, member CTwo-hybridBioGRID16189514 
FHL3MGC19547 | MGC23614 | MGC8696 | SLIM2four and a half LIM domains 3Two-hybridBioGRID16189514 
HOXA1BSAS | HOX1 | HOX1F | MGC45232homeobox A1Two-hybridBioGRID16189514 
HOXA9ABD-B | HOX1 | HOX1.7 | HOX1G | MGC1934homeobox A9Affinity Capture-Western
Two-hybrid		BioGRID16189514 
ILF3CBTF | DRBF | DRBP76 | MMP4 | MPHOSPH4 | MPP4 | NF-AT-90 | NF110 | NF90 | NFAR | NFAR-1 | NFAR2 | TCP110 | TCP80interleukin enhancer binding factor 3, 90kDaTwo-hybridBioGRID16189514 
KCTD5FLJ20040potassium channel tetramerisation domain containing 5Affinity Capture-MSBioGRID17353931 
KIAA1683MGC131731KIAA1683Two-hybridBioGRID16189514 
LOC116349-hypothetical protein BC014011Two-hybridBioGRID16189514 
LPAR2EDG-4 | EDG4 | FLJ93869 | LPA2lysophosphatidic acid receptor 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID14688263 
MOBKL1BC2orf6 | FLJ10788 | FLJ11595 | MATS1 | MOB1 | MOBK1B | Mob4BMOB1, Mps One Binder kinase activator-like 1B (yeast)Affinity Capture-MSBioGRID17353931 
NCK2GRB4 | NCKbetaNCK adaptor protein 2Two-hybridBioGRID16189514 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD,BioGRID11782456 
NUP210FLJ22389 | GP210 | KIAA0906 | POM210nucleoporin 210kDa-HPRD,BioGRID11782456 
ODF1HSPB10 | MGC129928 | MGC129929 | ODF | ODF2 | ODF27 | ODFP | ODFPG | ODFPGA | ODFPGB | RT7 | SODFouter dense fiber of sperm tails 1-HPRD,BioGRID12533418 
P4HBDSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideAffinity Capture-MSBioGRID17353931 
PDLIM4RILPDZ and LIM domain 4-HPRD,BioGRID10826496 
POM121DKFZp586G1822 | DKFZp586P2220 | FLJ41820 | KIAA0618 | MGC3792 | POM121APOM121 membrane glycoprotein (rat)Two-hybridBioGRID16189514 
PPP1R16AMGC14333 | MYPT3protein phosphatase 1, regulatory (inhibitor) subunit 16ATwo-hybridBioGRID16189514 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID14688263 
PTPN13DKFZp686J1497 | FAP-1 | PNP1 | PTP-BAS | PTP-BL | PTP1E | PTPL1 | PTPLEprotein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)-HPRD,BioGRID10826496 
PXNFLJ16691paxillin-HPRD,BioGRID14688263 
RNMTL1FLJ10581 | HC90RNA methyltransferase like 1Affinity Capture-MSBioGRID17353931 
RPS14EMTBribosomal protein S14Affinity Capture-MSBioGRID17353931 
SONBASS1 | C21orf50 | DBP-5 | FLJ21099 | FLJ33914 | KIAA1019 | NREBP | SON3SON DNA binding protein-HPRD11782456 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID14688263 
STOMBND7 | EPB7 | EPB72stomatinAffinity Capture-MSBioGRID17353931 
THRAP3FLJ22082 | MGC133082 | MGC133083 | TRAP150thyroid hormone receptor associated protein 3Affinity Capture-MSBioGRID17353931 
TPM4-tropomyosin 4-HPRD,BioGRID11782456 
VCLCMD1W | MVCLvinculinTwo-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 6653All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 7060All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE UP 12973All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182111All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 9457All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
TOMIDA METASTASIS DN 1811All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169111All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 6733All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP 5233All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 3731All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 10063All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 UP 3618All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181106All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 UP 4030All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239156All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2 11159All SZGR 2.0 genes in this pathway