Gene Page: TRPC3

Summary ?
GeneID7222
SymbolTRPC3
SynonymsSCA41|TRP3
Descriptiontransient receptor potential cation channel subfamily C member 3
ReferenceMIM:602345|HGNC:HGNC:12335|Ensembl:ENSG00000138741|HPRD:15999|Vega:OTTHUMG00000133069
Gene typeprotein-coding
Map location4q27
Pascal p-value0.044
Fetal beta-0.119
DMG1 (# studies)
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg087693004122871735TRPC37.85E-8-0.011.85E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CACYBP0.900.92
OCIAD10.840.84
ATP6V1D0.840.87
MRPS220.840.86
NKIRAS10.840.86
RHEB0.830.85
DNAJB90.820.83
COPS40.820.82
CALM20.810.86
NDUFAF40.810.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.18-0.46-0.21
SMTN-0.42-0.45
RP4-697K14.1-0.42-0.46
AC100783.1-0.42-0.35
AC010300.1-0.41-0.36
AF347015.2-0.41-0.20
HHIPL2-0.40-0.42
C10orf108-0.39-0.40
EGFL8-0.38-0.38
WDR86-0.37-0.38

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDa-HPRD15199065 
GNA11GNA-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)-HPRD15623527 
GNA11GNA-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)-HPRD11524429 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1Affinity Capture-WesternBioGRID14505576 
ITPR3FLJ36205 | IP3R | IP3R3inositol 1,4,5-triphosphate receptor, type 3-HPRD15623527 
ITPR3FLJ36205 | IP3R | IP3R3inositol 1,4,5-triphosphate receptor, type 3Reconstituted ComplexBioGRID11290752 
ITPR3FLJ36205 | IP3R | IP3R3inositol 1,4,5-triphosphate receptor, type 3-HPRD11524429 
MX1IFI-78K | IFI78 | MX | MxAmyxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)MxA interacts with TRPC3. This interaction was modeled on a demonstrated interaction between human MxA and TRPC3 from unspecified species.BIND15757897 
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaTRPC3 interacts with alpha-SNAP.BIND15327778 
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alpha-HPRD15327778 
PLCB1FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154phospholipase C, beta 1 (phosphoinositide-specific)-HPRD15623527 
PLCB2FLJ38135phospholipase C, beta 2-HPRD15623527 
PLCB3FLJ37084phospholipase C, beta 3 (phosphatidylinositol-specific)-HPRD15623527 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1PLCG1 interacts with TRPC3. This interaction was modelled on a demonstrated interaction between rat PLCG1 and human TRPC3.BIND15744307 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD15744307 |15766521 
SLC8A1DKFZp779F0871 | FLJ37694 | FLJ43417 | MGC119581 | NCX1solute carrier family 8 (sodium/calcium exchanger), member 1-HPRD14736881 
STX3STX3Asyntaxin 3-HPRD15623527 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1-HPRD9215637 |12032305 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1Affinity Capture-Western
in vivo		BioGRID9215637 |12857742 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3Affinity Capture-Western
FRET		BioGRID12032305 
TRPC4HTRP4 | MGC119570 | MGC119571 | MGC119572 | MGC119573 | TRP4transient receptor potential cation channel, subfamily C, member 4Affinity Capture-WesternBioGRID12857742 
TRPC5TRP5transient receptor potential cation channel, subfamily C, member 5Affinity Capture-WesternBioGRID12857742 
TRPC6FLJ11098 | FLJ14863 | FSGS2 | TRP6transient receptor potential cation channel, subfamily C, member 6-HPRD,BioGRID12032305 
TRPC6FLJ11098 | FLJ14863 | FSGS2 | TRP6transient receptor potential cation channel, subfamily C, member 6-HPRD15623527 
TRPC7TRP7transient receptor potential cation channel, subfamily C, member 7FRETBioGRID12032305 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)-HPRD15327778 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)TRPC3 interacts with VAMP2.BIND15327778 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID PI3K PLC TRK PATHWAY 3631All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS 106All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME EFFECTS OF PIP2 HYDROLYSIS 2517All SZGR 2.0 genes in this pathway
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING 118All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 4130All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME PLATELET CALCIUM HOMEOSTASIS 1810All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 48HR 96All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 8369All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3 UNMETHYLATED 6331All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228119All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway