Gene Page: TRPC4
Summary ?
| GeneID | 7223 |
| Symbol | TRPC4 |
| Synonyms | HTRP-4|HTRP4|TRP4 |
| Description | transient receptor potential cation channel subfamily C member 4 |
| Reference | MIM:603651|HGNC:HGNC:12336|Ensembl:ENSG00000133107|HPRD:09154|Vega:OTTHUMG00000016752 |
| Gene type | protein-coding |
| Map location | 13q13.3 |
| Pascal p-value | 2.184E-4 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AFG3L2 | 0.88 | 0.81 |
| SLC4A1AP | 0.87 | 0.80 |
| DDX1 | 0.86 | 0.85 |
| GRPEL1 | 0.86 | 0.77 |
| NARS | 0.85 | 0.81 |
| NUDT9 | 0.85 | 0.82 |
| DLD | 0.85 | 0.85 |
| KLRAQ1 | 0.85 | 0.79 |
| DDX24 | 0.84 | 0.77 |
| PSMD7 | 0.84 | 0.77 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.76 | -0.44 |
| MT-CO2 | -0.68 | -0.44 |
| AF347015.2 | -0.68 | -0.45 |
| AF347015.8 | -0.68 | -0.44 |
| AF347015.31 | -0.66 | -0.45 |
| HIGD1B | -0.66 | -0.46 |
| AF347015.18 | -0.65 | -0.42 |
| IFI27 | -0.65 | -0.50 |
| AF347015.33 | -0.64 | -0.43 |
| MT-CYB | -0.64 | -0.41 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
| REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | 11 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME NETRIN1 SIGNALING | 41 | 30 | All SZGR 2.0 genes in this pathway |
| LIU PROSTATE CANCER DN | 481 | 290 | All SZGR 2.0 genes in this pathway |
| WILCOX RESPONSE TO PROGESTERONE UP | 152 | 90 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| RIZ ERYTHROID DIFFERENTIATION 6HR | 40 | 23 | All SZGR 2.0 genes in this pathway |
| WANG SMARCE1 TARGETS DN | 371 | 218 | All SZGR 2.0 genes in this pathway |
| MCCLUNG CREB1 TARGETS UP | 100 | 72 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| BOQUEST STEM CELL CULTURED VS FRESH UP | 425 | 298 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| ZEMBUTSU SENSITIVITY TO CISPLATIN | 20 | 14 | All SZGR 2.0 genes in this pathway |