Summary ?
GeneID7306
SymbolTYRP1
SynonymsCAS2|CATB|GP75|OCA3|TRP|TRP1|TYRP|b-PROTEIN
Descriptiontyrosinase-related protein 1
ReferenceMIM:115501|HGNC:HGNC:12450|Ensembl:ENSG00000107165|HPRD:00283|Vega:OTTHUMG00000021034
Gene typeprotein-coding
Map location9p23
Pascal p-value0.746
Fetal beta-2.694
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GP1BB0.660.52
GDF10.640.62
AP001362.10.640.54
PPP1R3G0.600.53
ZNF7710.600.51
PCSK1N0.590.50
ACBD40.590.59
MRPL410.570.61
C21orf20.570.47
C17orf890.560.52
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF654-0.40-0.43
SESTD1-0.39-0.42
SYT14-0.39-0.41
ZBTB24-0.39-0.40
AC012621.2-0.39-0.41
RNMT-0.39-0.42
RNF111-0.38-0.41
CSDE1-0.38-0.41
RLIM-0.38-0.42
IPO7-0.38-0.42

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TYROSINE METABOLISM 4230All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 8554All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP 3328All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 4NM UP 2315All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 8157All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP 6445All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
GRANDVAUX IRF3 TARGETS DN 1914All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 6946All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN 10165All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 12775All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway