Gene Page: NR1H2
Summary ?
| GeneID | 7376 |
| Symbol | NR1H2 |
| Synonyms | LXR-b|LXRB|NER|NER-I|RIP15|UNR |
| Description | nuclear receptor subfamily 1 group H member 2 |
| Reference | MIM:600380|HGNC:HGNC:7965|Ensembl:ENSG00000131408|HPRD:02660|Vega:OTTHUMG00000183036 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.026 |
| Sherlock p-value | 0.996 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11984825 | chr8 | 1201727 | NR1H2 | 7376 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PRKRA | 0.92 | 0.89 |
| GARS | 0.91 | 0.88 |
| ATP1B3 | 0.91 | 0.90 |
| FARSB | 0.91 | 0.87 |
| UCHL1 | 0.89 | 0.85 |
| SLC25A17 | 0.89 | 0.89 |
| ATXN10 | 0.89 | 0.88 |
| VDAC2 | 0.89 | 0.88 |
| TOR1A | 0.89 | 0.83 |
| RAB11A | 0.89 | 0.89 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.81 | -0.73 |
| AF347015.8 | -0.80 | -0.74 |
| AF347015.2 | -0.80 | -0.75 |
| AF347015.33 | -0.79 | -0.73 |
| MT-CYB | -0.79 | -0.73 |
| AF347015.31 | -0.78 | -0.71 |
| AF347015.26 | -0.77 | -0.73 |
| AF347015.15 | -0.77 | -0.72 |
| AF347015.27 | -0.77 | -0.73 |
| AF347015.21 | -0.75 | -0.69 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID RXR VDR PATHWAY | 26 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 49 | 36 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| BIDUS METASTASIS DN | 161 | 93 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
| HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP | 81 | 57 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| XU CREBBP TARGETS DN | 44 | 31 | All SZGR 2.0 genes in this pathway |
| HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR | 37 | 22 | All SZGR 2.0 genes in this pathway |
| LI ADIPOGENESIS BY ACTIVATED PPARG | 17 | 12 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D UP | 210 | 124 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | All SZGR 2.0 genes in this pathway |