Gene Page: USF1

Summary ?
GeneID7391
SymbolUSF1
SynonymsFCHL|FCHL1|HYPLIP1|MLTF|MLTFI|UEF|bHLHb11
Descriptionupstream transcription factor 1
ReferenceMIM:191523|HGNC:HGNC:12593|Ensembl:ENSG00000158773|HPRD:01880|Vega:OTTHUMG00000031472
Gene typeprotein-coding
Map location1q22-q23
Sherlock p-value0.951
Fetal beta0.124
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1864549chr279699410USF173911.259E-4trans
rs10484309chr6117489335USF173910.01trans
rs3798172chr6160556042USF173910.07trans
rs7871241chr9131651203USF173910.15trans
rs17101174chr11103464951USF173910.19trans
rs17070045chr1358400458USF173910.02trans
rs6503212chr179392733USF173910.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
JDP20.800.82
CHRD0.770.72
LRRC380.770.72
TMEM38A0.760.82
NECAB30.760.62
ITGA110.750.39
FMNL10.750.70
KCNIP30.750.83
CX3CL10.750.81
MICAL20.750.67
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUBB2B-0.44-0.60
TRAF4-0.44-0.62
KIAA1949-0.44-0.51
COTL1-0.43-0.49
AF186192.1-0.43-0.60
IDH1-0.42-0.51
CARHSP1-0.41-0.63
LEMD1-0.41-0.55
TMC2-0.41-0.60
CD24-0.41-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingIDA2249772 
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingIMP8576131 |18234320 
GO:0005515protein bindingIPI17353931 
GO:0043425bHLH transcription factor bindingIPI8576131 
GO:0030528transcription regulator activityIEA-
GO:0042803protein homodimerization activityIPI8576131 
GO:0042803protein homodimerization activityTAS2249772 
GO:0046982protein heterodimerization activityIPI8576131 
GO:0043565sequence-specific DNA bindingIDA2249772 |8576131 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucoseIMP7852331 
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucoseISS-
GO:0001666response to hypoxiaIMP12917334 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006366transcription from RNA polymerase II promoterIDA2249772 
GO:0010552positive regulation of specific transcription from RNA polymerase II promoterIMP8576131 |18234320 
GO:0009411response to UVISS-
GO:0042593glucose homeostasisTAS15054483 
GO:0019086late viral mRNA transcriptionIDA2249772 
GO:0045449regulation of transcriptionIEA-
GO:0055088lipid homeostasisISS-
GO:0051918negative regulation of fibrinolysisIC18234320 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 3829All SZGR 2.0 genes in this pathway
WATANABE COLON CANCER MSI VS MSS UP 2918All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLIFIED IN SOFT TISSUE CANCER 137All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE DN 6139All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163100All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 10063All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS 8056All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 9340All SZGR 2.0 genes in this pathway