Gene Page: USF2

Summary ?
GeneID7392
SymbolUSF2
SynonymsFIP|bHLHb12
Descriptionupstream transcription factor 2, c-fos interacting
ReferenceMIM:600390|HGNC:HGNC:12594|Ensembl:ENSG00000105698|HPRD:02668|Vega:OTTHUMG00000183182
Gene typeprotein-coding
Map location19q13
Pascal p-value0.122
Sherlock p-value0.489
Fetal beta-0.229
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
USF2chr1935760545GANM_003367
NM_207291		.
.		silent
silent		SchizophreniaDNM:Fromer_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg145586391935760677USF23.13E-4-0.3170.04DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BIRC5API4 | EPR-1baculoviral IAP repeat-containing 5Affinity Capture-MSBioGRID17353931 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID14502648 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID10434034 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD1589769 
FUSCHOP | FUS-CHOP | FUS1 | TLS | TLS/CHOP | hnRNP-P2fusion (involved in t(12;16) in malignant liposarcoma)Affinity Capture-MSBioGRID17353931 
HSPA4LAPG-1 | Osp94heat shock 70kDa protein 4-likeAffinity Capture-MSBioGRID17353931 
IGF2RCD222 | CIMPR | M6P-R | MPR1 | MPRIinsulin-like growth factor 2 receptorAn unspecified isoform of USF2 interacts with IGF2R promoter.BIND12857727 
MAFMGC71685 | c-MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)-HPRD,BioGRID9070273 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)Affinity Capture-MSBioGRID17353931 
PPARGC1ALEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1peroxisome proliferator-activated receptor gamma, coactivator 1 alpha-HPRD12611894 
PPRC1KIAA0595 | MGC74642 | PRC | RP11-302K17.6peroxisome proliferator-activated receptor gamma, coactivator-related 1Affinity Capture-Western
Reconstituted Complex		BioGRID12611894 
PTP4A2HH13 | HH7-2 | HU-PP-1 | OV-1 | PRL-2 | PRL2 | PTP4A | PTPCAAX2 | ptp-IV1a | ptp-IV1bprotein tyrosine phosphatase type IVA, member 2Affinity Capture-MSBioGRID17353931 
S100A860B8AG | CAGA | CFAG | CGLA | CP-10 | L1Ag | MA387 | MIF | MRP8 | NIF | P8S100 calcium binding protein A8Affinity Capture-MSBioGRID17353931 
S100A960B8AG | CAGB | CFAG | CGLB | L1AG | LIAG | MAC387 | MIF | MRP14 | NIF | P14S100 calcium binding protein A9Affinity Capture-MSBioGRID17353931 
SERPINB3HsT1196 | SCC | SCCA-1 | SCCA-PD | SCCA1 | T4-Aserpin peptidase inhibitor, clade B (ovalbumin), member 3Affinity Capture-MSBioGRID17353931 
SERPINB4LEUPIN | PI11 | SCCA-2 | SCCA1 | SCCA2serpin peptidase inhibitor, clade B (ovalbumin), member 4Affinity Capture-MSBioGRID17353931 
USF1FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11upstream transcription factor 1-HPRD8576131 |9053857 
USF1FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11upstream transcription factor 1Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID8576131 |17353931 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interacting-HPRD8576131 |9070273 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interactingAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID8576131 |17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID FRA PATHWAY 3728All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 3320All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164118All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 8767All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 8152All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN 5430All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA UP 2823All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 5036All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 6948All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS DN 4026All SZGR 2.0 genes in this pathway