Gene Page: VCP
Summary ?
| GeneID | 7415 |
| Symbol | VCP |
| Synonyms | ALS14|CMT2Y|HEL-220|HEL-S-70|IBMPFD|IBMPFD1|TERA|p97 |
| Description | valosin containing protein |
| Reference | MIM:601023|HGNC:HGNC:12666|Ensembl:ENSG00000165280|HPRD:03013|Vega:OTTHUMG00000019855 |
| Gene type | protein-coding |
| Map location | 9p13.3 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 0.986 |
| eGene | Myers' cis & trans |
| Support | RNA AND PROTEIN SYNTHESIS G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7132043 | chr12 | 80968399 | VCP | 7415 | 0.08 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MFN2 | 0.88 | 0.87 |
| OTUD5 | 0.87 | 0.84 |
| GNL1 | 0.87 | 0.85 |
| ALKBH5 | 0.87 | 0.86 |
| HDLBP | 0.87 | 0.85 |
| EXOC3 | 0.86 | 0.83 |
| MYST2 | 0.86 | 0.85 |
| SCRN1 | 0.85 | 0.87 |
| DIRAS1 | 0.85 | 0.87 |
| SRP68 | 0.85 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.68 | -0.55 |
| C1orf54 | -0.65 | -0.59 |
| FXYD1 | -0.63 | -0.55 |
| MT-CO2 | -0.63 | -0.53 |
| HIGD1B | -0.62 | -0.54 |
| NOSTRIN | -0.61 | -0.49 |
| AF347015.31 | -0.61 | -0.53 |
| AP002478.3 | -0.61 | -0.54 |
| AF347015.8 | -0.60 | -0.52 |
| VAMP5 | -0.60 | -0.50 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AMFR | GP78 | RNF45 | autocrine motility factor receptor | - | HPRD,BioGRID | 15331598 |
| ATXN3 | AT3 | ATX3 | JOS | MJD | MJD1 | SCA3 | ataxin 3 | - | HPRD,BioGRID | 12944474 |
| BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | - | HPRD,BioGRID | 10855792 |
| CHEK2 | CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53 | CHK2 checkpoint homolog (S. pombe) | Affinity Capture-Western | BioGRID | 17525332 |
| DERL1 | DER-1 | DER1 | FLJ13784 | FLJ42092 | MGC3067 | PRO2577 | Der1-like domain family, member 1 | - | HPRD | 15215856 |
| HDAC6 | FLJ16239 | HD6 | JM21 | histone deacetylase 6 | - | HPRD | 11689694 |
| HLA-B | AS | HLA-B-7301 | HLA-B73 | HLAB | HLAC | SPDA1 | major histocompatibility complex, class I, B | Affinity Capture-MS | BioGRID | 17353931 |
| IKBKE | IKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | Affinity Capture-MS | BioGRID | 17353931 |
| JAK2 | JTK10 | Janus kinase 2 (a protein tyrosine kinase) | - | HPRD,BioGRID | 11087817 |
| MCC | DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 | mutated in colorectal cancers | Affinity Capture-MS | BioGRID | 17353931 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | - | HPRD,BioGRID | 9452483 |
| NSFL1C | MGC3347 | UBX1 | UBXD10 | UBXN2C | dJ776F14.1 | p47 | NSFL1 (p97) cofactor (p47) | - | HPRD,BioGRID | 12529442 |12810701|12810701 |
| NSFL1C | MGC3347 | UBX1 | UBXD10 | UBXN2C | dJ776F14.1 | p47 | NSFL1 (p97) cofactor (p47) | - | HPRD | 12810701 |
| PPM1B | MGC21657 | PP2C-beta-X | PP2CB | PP2CBETA | PPC2BETAX | protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC1 | MGC24583 | MGC8541 | P26S4 | S4 | p56 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | - | HPRD,BioGRID | 9452483 |
| SELS | AD-015 | ADO15 | MGC104346 | MGC2553 | SBBI8 | SEPS1 | VIMP | selenoprotein S | VIMP interacts with p97. | BIND | 15215856 |
| SELS | AD-015 | ADO15 | MGC104346 | MGC2553 | SBBI8 | SEPS1 | VIMP | selenoprotein S | Affinity Capture-Western Reconstituted Complex | BioGRID | 15215856 |
| SGK1 | SGK | serum/glucocorticoid regulated kinase 1 | Affinity Capture-MS | BioGRID | 17353931 |
| STX5 | SED5 | STX5A | syntaxin 5 | - | HPRD | 9506515 |
| TOMM34 | HTOM34P | TOM34 | URCC3 | translocase of outer mitochondrial membrane 34 | - | HPRD,BioGRID | 11913976 |
| TRAF6 | MGC:3310 | RNF85 | TNF receptor-associated factor 6 | Affinity Capture-MS | BioGRID | 17353931 |
| UBE4B | E4 | HDNB1 | KIAA0684 | UBOX3 | UFD2 | ubiquitination factor E4B (UFD2 homolog, yeast) | - | HPRD | 12504083 |
| VCP | IBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97 | valosin-containing protein | - | HPRD,BioGRID | 12807884 |
| VCPIP1 | DKFZp686G038 | DUBA3 | FLJ23132 | FLJ60694 | KIAA1850 | VCIP135 | valosin containing protein (p97)/p47 complex interacting protein 1 | - | HPRD | 12473691 |
| WDR8 | FLJ20430 | MGC99569 | WD repeat domain 8 | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP | 276 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| FAELT B CLL WITH VH3 21 UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR UP | 156 | 101 | All SZGR 2.0 genes in this pathway |
| ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM | 66 | 47 | All SZGR 2.0 genes in this pathway |
| ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST | 132 | 93 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1 TARGETS | 90 | 71 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1B TARGETS | 92 | 68 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| ALFANO MYC TARGETS | 239 | 156 | All SZGR 2.0 genes in this pathway |
| KUMAR PATHOGEN LOAD BY MACROPHAGES | 275 | 155 | All SZGR 2.0 genes in this pathway |
| KUMAR AUTOPHAGY NETWORK | 71 | 46 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |