Gene Page: VEGFB

Summary ?
GeneID7423
SymbolVEGFB
SynonymsVEGFL|VRF
Descriptionvascular endothelial growth factor B
ReferenceMIM:601398|HGNC:HGNC:12681|HPRD:03237|
Gene typeprotein-coding
Map location11q13
Pascal p-value0.013
Fetal beta-0.57
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg054928451164002298VEGFB6.11E-6-0.2750.011DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1027497chr4125640906VEGFB74230.1trans
rs17008527chr4125656445VEGFB74230.1trans
rs6879593chr575253310VEGFB74230.03trans
rs11142564chr973365108VEGFB74230.11trans
rs16940174chr1558686337VEGFB74230.18trans
rs5979195chrX9835238VEGFB74230.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TPP10.860.86
ABHD150.840.83
TPCN10.810.82
HEPACAM0.810.77
IL17D0.810.80
LRP100.810.82
RETSAT0.810.82
NACC20.800.85
MOCS10.800.82
TIMP30.800.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRG1-0.54-0.62
C11orf57-0.49-0.58
POLB-0.48-0.54
CYP2R1-0.48-0.55
AC026786.2-0.48-0.54
NDUFAF2-0.48-0.59
EXOSC8-0.47-0.56
STMN1-0.47-0.46
MED19-0.46-0.49
RBMX2-0.46-0.51

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 5240All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER 4233All SZGR 2.0 genes in this pathway
PID VEGF VEGFR PATHWAY 106All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 2623All SZGR 2.0 genes in this pathway
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS 106All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 13378All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
AGARWAL AKT PATHWAY TARGETS 109All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 2920All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 6445All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE UP 3823All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP 4940All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS 8148All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 7149All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 4934All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 7049All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178108All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 10575All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA 96All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP 5944All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KANG AR TARGETS DN 1912All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 14094All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway