SZGR2

Summary ?

GeneID	7439
Symbol	BEST1
Synonyms	ARB\|BEST\|BMD\|RP50\|TU15B\|VMD2
Description	bestrophin 1
Reference	MIM:607854\|HGNC:HGNC:12703\|Ensembl:ENSG00000167995\|HPRD:01094\|Vega:OTTHUMG00000167469
Gene type	protein-coding
Map location	11q13
Pascal p-value	0.652
Sherlock p-value	0.388
DEG p-value	DEG:Zhao_2015:p=9.83e-05:q=0.0693
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Zhao_2015	RNA Sequencing analysis	Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TPBG	0.67	0.68
C3orf58	0.62	0.59
ACTN1	0.62	0.69
RAP1GAP	0.60	0.70
CCNO	0.59	0.53
WDR42A	0.59	0.72
ADCY3	0.59	0.67
PPP1R16B	0.58	0.59
ABLIM2	0.58	0.69
RP5-1187M17.1	0.58	0.69

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.18	-0.30	-0.23
AF347015.21	-0.30	-0.24
DBI	-0.29	-0.38
IL32	-0.27	-0.30
AF347015.2	-0.26	-0.18
BTBD17	-0.25	-0.37
ANP32C	-0.25	-0.32
AF347015.8	-0.25	-0.20
AF347015.31	-0.25	-0.22
MT-ATP8	-0.25	-0.20

Section V. Pathway annotation