Summary ?
GeneID7471
SymbolWNT1
SynonymsBMND16|INT1|OI15
Descriptionwingless-type MMTV integration site family member 1
ReferenceMIM:164820|HGNC:HGNC:12774|HPRD:01276|
Gene typeprotein-coding
Map location12q13
Pascal p-value0.285
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10506284chr1249752650WNT174710.02cis
rs12030788chr166768128WNT174710.07trans
rs725667chr168488649WNT174710.02trans
rs11807500chr168503525WNT174710trans
rs11808365chr168507122WNT174710.02trans
rs12086539chr168507537WNT174710.02trans
rs11801053chr168512170WNT174710.05trans
rs17091285chr171957915WNT174710.06trans
rs6663174chr182004206WNT174710.15trans
rs12033254chr1165654868WNT174710.11trans
rs16843346chr1198543026WNT174710.01trans
rs1080976chr1198545551WNT174710.1trans
rs16843417chr1198568664WNT174710.04trans
rs16843424chr1198572758WNT174710.14trans
rs16843476chr1198591076WNT174710.13trans
rs16843670chr1198650005WNT174715.147E-4trans
rs10925947chr1235701552WNT174710.06trans
rs636167chr1237402264WNT174710.08trans
rs1876946chr1245459606WNT174710.05trans
rs17490288chr236902427WNT174710.13trans
rs2014805chr2175165192WNT174710trans
rs17394437chr2176801863WNT174710.14trans
rs4674479chr2220806451WNT174710.1trans
rs7586700chr2237769742WNT174710.09trans
rs7574988chr2237770124WNT174710.09trans
rs9831161chr343768017WNT174710.17trans
rs17075993chr343800880WNT174710.04trans
rs1014141chr343810759WNT174710trans
rs7615639chr343852564WNT174710.01trans
rs4234437chr343863375WNT174710.2trans
rs9809244chr362078922WNT174710.15trans
rs17044826chr366620522WNT174710.03trans
rs17072034chr4182594793WNT174710.02trans
rs16881626chr58901096WNT174710.09trans
rs16881658chr58909712WNT174710.04trans
rs2962730chr58946017WNT174710.13trans
rs2962729chr58946323WNT174710.08trans
rs1478417chr5122277035WNT174710.04trans
rs1368303chr5147672388WNT174710.15trans
rs9450829chr688624436WNT174710.04trans
rs6935871chr6109107049WNT174710.01trans
rs887719chr721184272WNT174710trans
rs320082chr729105404WNT174711.885E-10trans
rs317720chr729110633WNT174713.381E-9trans
rs317714chr729115553WNT174715.579E-9trans
rs317724chr729120565WNT174713.381E-9trans
rs10487032chr788343822WNT174710.18trans
rs2294031chr81812077WNT174710.1trans
rs7830307chr836560734WNT174710.03trans
rs7837675chr836615251WNT174710.01trans
rs1981322chr836630228WNT174710.01trans
rs16923894chr859700319WNT174710.08trans
rs16899109chr8102243951WNT174710.19trans
rs16886605chr8115894398WNT174710.02trans
rs1494750chr8116094224WNT174710.1trans
rs1831517chr92513405WNT174710.13trans
rs7046585chr98681939WNT174710.15trans
rs7868778chr9133811342WNT174710.08trans
rs4607971chr1019407890WNT174710.03trans
rs11203077chr1091097084WNT174712.067E-6trans
rs16933545chr117918293WNT174710.05trans
rs10834670chr1125404015WNT174710.01trans
rs10834671chr1125404269WNT174710.01trans
rs2514177chr1157808227WNT174710.19trans
rs2122803chr1157811883WNT174710.19trans
rs2443424chr1157846310WNT174710.19trans
rs2443436chr1157859737WNT174710.1trans
rs17152341chr1157872189WNT174710.19trans
rs11229262chr1157905460WNT174710.19trans
rs10791832chr1165683917WNT174710.01trans
rs17119713chr11116338674WNT174710.14trans
rs11221223chr11128123258WNT174710.04trans
rs12310284chr1228738932WNT174710.17trans
rs11052230chr1232931283WNT174710.04trans
rs11176643chr1267629785WNT174712.839E-6trans
rs17764482chr1282483756WNT174710.06trans
rs7963156chr1297472647WNT174710.18trans
rs17026331chr1297478907WNT174710trans
rs11066476chr12113465366WNT174710trans
rs12312224chr12129771735WNT174710.16trans
rs17069275chr1347573172WNT174710.16trans
rs7322001chr1394895345WNT174710.14trans
rs17793815chr1422794531WNT174710.04trans
rs11158850chr1470757171WNT174710.04trans
rs8010077chr1475242784WNT174710.16trans
rs1862127chr1478407295WNT174710.11trans
rs17120009chr1484924155WNT174710.06trans
rs3790050chr1494421666WNT174710.18trans
rs11635209chr1532333996WNT174710.12trans
rs8043232chr1541282370WNT174710.03trans
rs4468583chr1541328652WNT174710.03trans
rs2412599chr1541347970WNT174710.03trans
rs16971463chr1541370625WNT174710.01trans
rs518137chr1541381512WNT174710.01trans
rs11072201chr1570857175WNT174710.01trans
rs17781350chr1571108134WNT174710trans
rs7200513chr1617219474WNT174710.15trans
rs3829495chr1617221986WNT174710.04trans
rs16949485chr1679104374WNT174710.15trans
rs12452652chr1772235560WNT174711.811E-8trans
rs17188689chr1823359136WNT174710.01trans
rs10513931chr1861569462WNT174710.06trans
rs2469009chr1870713334WNT174710.1trans
rs17087020chr1870828793WNT174710.09trans
rs1893731chr1870954644WNT174710.16trans
rs17056775chr1872988809WNT174710trans
rs321929chr1952835463WNT174710.14trans
rs10485563chr2016813100WNT174710.02trans
rs1523533chr2051329866WNT174710.03trans
rs2689370chr2051335422WNT174710.11trans
rs2745070chr2051337694WNT174710.11trans
rs402866chr2128531675WNT174710.15trans
rs5992705chr2217914003WNT174710.11trans
rs13057846chr2226291756WNT174710.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DHX150.950.97
GPBP10.950.96
PRPF4B0.950.97
PAPOLA0.950.96
SUZ120.950.97
MSH20.950.95
YME1L10.940.95
NUP1330.940.97
METTL140.940.94
UHRF20.940.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.75-0.88
FXYD1-0.75-0.87
AF347015.31-0.74-0.86
AF347015.33-0.73-0.85
IFI27-0.73-0.86
AF347015.27-0.72-0.84
MT-CYB-0.72-0.84
AF347015.8-0.72-0.86
HLA-F-0.70-0.77
HIGD1B-0.70-0.84

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingNASNeurotransmitter (GO term level: 4)15592430 
GO:0004871signal transducer activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)2202907 
GO:0022004midbrain-hindbrain boundary maturation during brain developmentIEABrain (GO term level: 12)-
GO:0048664neuron fate determinationIEAneuron (GO term level: 10)-
GO:0001708cell fate specificationTAS15592430 
GO:0007223Wnt receptor signaling pathway, calcium modulating pathwayIEA-
GO:0007163establishment or maintenance of cell polarityTAS15592430 
GO:0007275multicellular organismal developmentIEA-
GO:0016477cell migrationTAS15592430 
GO:0030154cell differentiationTAS15592430 
GO:0042472inner ear morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG HEDGEHOG SIGNALING PATHWAY 5642All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA 5544All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY 3729All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 2726All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY 1515All SZGR 2.0 genes in this pathway
BIOCARTA PS1 PATHWAY 1414All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 2624All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 4639All SZGR 2.0 genes in this pathway
PID WNT SIGNALING PATHWAY 2823All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 8461All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 8858All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS 3124All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 119All SZGR 2.0 genes in this pathway
NADLER HYPERGLYCEMIA AT OBESITY 5835All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 9772All SZGR 2.0 genes in this pathway
DE YY1 TARGETS UP 2014All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN IPS WITH HCP H3K27ME3 10276All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98227233m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-130/301260266m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-140168174m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-148/152261267m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-19685691m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-34/449263269m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC