Gene Page: WNT1
Summary ?
GeneID | 7471 |
Symbol | WNT1 |
Synonyms | BMND16|INT1|OI15 |
Description | wingless-type MMTV integration site family member 1 |
Reference | MIM:164820|HGNC:HGNC:12774|HPRD:01276| |
Gene type | protein-coding |
Map location | 12q13 |
Pascal p-value | 0.285 |
eGene | Myers' cis & trans Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 4 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs10506284 | chr12 | 49752650 | WNT1 | 7471 | 0.02 | cis | ||
rs12030788 | chr1 | 66768128 | WNT1 | 7471 | 0.07 | trans | ||
rs725667 | chr1 | 68488649 | WNT1 | 7471 | 0.02 | trans | ||
rs11807500 | chr1 | 68503525 | WNT1 | 7471 | 0 | trans | ||
rs11808365 | chr1 | 68507122 | WNT1 | 7471 | 0.02 | trans | ||
rs12086539 | chr1 | 68507537 | WNT1 | 7471 | 0.02 | trans | ||
rs11801053 | chr1 | 68512170 | WNT1 | 7471 | 0.05 | trans | ||
rs17091285 | chr1 | 71957915 | WNT1 | 7471 | 0.06 | trans | ||
rs6663174 | chr1 | 82004206 | WNT1 | 7471 | 0.15 | trans | ||
rs12033254 | chr1 | 165654868 | WNT1 | 7471 | 0.11 | trans | ||
rs16843346 | chr1 | 198543026 | WNT1 | 7471 | 0.01 | trans | ||
rs1080976 | chr1 | 198545551 | WNT1 | 7471 | 0.1 | trans | ||
rs16843417 | chr1 | 198568664 | WNT1 | 7471 | 0.04 | trans | ||
rs16843424 | chr1 | 198572758 | WNT1 | 7471 | 0.14 | trans | ||
rs16843476 | chr1 | 198591076 | WNT1 | 7471 | 0.13 | trans | ||
rs16843670 | chr1 | 198650005 | WNT1 | 7471 | 5.147E-4 | trans | ||
rs10925947 | chr1 | 235701552 | WNT1 | 7471 | 0.06 | trans | ||
rs636167 | chr1 | 237402264 | WNT1 | 7471 | 0.08 | trans | ||
rs1876946 | chr1 | 245459606 | WNT1 | 7471 | 0.05 | trans | ||
rs17490288 | chr2 | 36902427 | WNT1 | 7471 | 0.13 | trans | ||
rs2014805 | chr2 | 175165192 | WNT1 | 7471 | 0 | trans | ||
rs17394437 | chr2 | 176801863 | WNT1 | 7471 | 0.14 | trans | ||
rs4674479 | chr2 | 220806451 | WNT1 | 7471 | 0.1 | trans | ||
rs7586700 | chr2 | 237769742 | WNT1 | 7471 | 0.09 | trans | ||
rs7574988 | chr2 | 237770124 | WNT1 | 7471 | 0.09 | trans | ||
rs9831161 | chr3 | 43768017 | WNT1 | 7471 | 0.17 | trans | ||
rs17075993 | chr3 | 43800880 | WNT1 | 7471 | 0.04 | trans | ||
rs1014141 | chr3 | 43810759 | WNT1 | 7471 | 0 | trans | ||
rs7615639 | chr3 | 43852564 | WNT1 | 7471 | 0.01 | trans | ||
rs4234437 | chr3 | 43863375 | WNT1 | 7471 | 0.2 | trans | ||
rs9809244 | chr3 | 62078922 | WNT1 | 7471 | 0.15 | trans | ||
rs17044826 | chr3 | 66620522 | WNT1 | 7471 | 0.03 | trans | ||
rs17072034 | chr4 | 182594793 | WNT1 | 7471 | 0.02 | trans | ||
rs16881626 | chr5 | 8901096 | WNT1 | 7471 | 0.09 | trans | ||
rs16881658 | chr5 | 8909712 | WNT1 | 7471 | 0.04 | trans | ||
rs2962730 | chr5 | 8946017 | WNT1 | 7471 | 0.13 | trans | ||
rs2962729 | chr5 | 8946323 | WNT1 | 7471 | 0.08 | trans | ||
rs1478417 | chr5 | 122277035 | WNT1 | 7471 | 0.04 | trans | ||
rs1368303 | chr5 | 147672388 | WNT1 | 7471 | 0.15 | trans | ||
rs9450829 | chr6 | 88624436 | WNT1 | 7471 | 0.04 | trans | ||
rs6935871 | chr6 | 109107049 | WNT1 | 7471 | 0.01 | trans | ||
rs887719 | chr7 | 21184272 | WNT1 | 7471 | 0 | trans | ||
rs320082 | chr7 | 29105404 | WNT1 | 7471 | 1.885E-10 | trans | ||
rs317720 | chr7 | 29110633 | WNT1 | 7471 | 3.381E-9 | trans | ||
rs317714 | chr7 | 29115553 | WNT1 | 7471 | 5.579E-9 | trans | ||
rs317724 | chr7 | 29120565 | WNT1 | 7471 | 3.381E-9 | trans | ||
rs10487032 | chr7 | 88343822 | WNT1 | 7471 | 0.18 | trans | ||
rs2294031 | chr8 | 1812077 | WNT1 | 7471 | 0.1 | trans | ||
rs7830307 | chr8 | 36560734 | WNT1 | 7471 | 0.03 | trans | ||
rs7837675 | chr8 | 36615251 | WNT1 | 7471 | 0.01 | trans | ||
rs1981322 | chr8 | 36630228 | WNT1 | 7471 | 0.01 | trans | ||
rs16923894 | chr8 | 59700319 | WNT1 | 7471 | 0.08 | trans | ||
rs16899109 | chr8 | 102243951 | WNT1 | 7471 | 0.19 | trans | ||
rs16886605 | chr8 | 115894398 | WNT1 | 7471 | 0.02 | trans | ||
rs1494750 | chr8 | 116094224 | WNT1 | 7471 | 0.1 | trans | ||
rs1831517 | chr9 | 2513405 | WNT1 | 7471 | 0.13 | trans | ||
rs7046585 | chr9 | 8681939 | WNT1 | 7471 | 0.15 | trans | ||
rs7868778 | chr9 | 133811342 | WNT1 | 7471 | 0.08 | trans | ||
rs4607971 | chr10 | 19407890 | WNT1 | 7471 | 0.03 | trans | ||
rs11203077 | chr10 | 91097084 | WNT1 | 7471 | 2.067E-6 | trans | ||
rs16933545 | chr11 | 7918293 | WNT1 | 7471 | 0.05 | trans | ||
rs10834670 | chr11 | 25404015 | WNT1 | 7471 | 0.01 | trans | ||
rs10834671 | chr11 | 25404269 | WNT1 | 7471 | 0.01 | trans | ||
rs2514177 | chr11 | 57808227 | WNT1 | 7471 | 0.19 | trans | ||
rs2122803 | chr11 | 57811883 | WNT1 | 7471 | 0.19 | trans | ||
rs2443424 | chr11 | 57846310 | WNT1 | 7471 | 0.19 | trans | ||
rs2443436 | chr11 | 57859737 | WNT1 | 7471 | 0.1 | trans | ||
rs17152341 | chr11 | 57872189 | WNT1 | 7471 | 0.19 | trans | ||
rs11229262 | chr11 | 57905460 | WNT1 | 7471 | 0.19 | trans | ||
rs10791832 | chr11 | 65683917 | WNT1 | 7471 | 0.01 | trans | ||
rs17119713 | chr11 | 116338674 | WNT1 | 7471 | 0.14 | trans | ||
rs11221223 | chr11 | 128123258 | WNT1 | 7471 | 0.04 | trans | ||
rs12310284 | chr12 | 28738932 | WNT1 | 7471 | 0.17 | trans | ||
rs11052230 | chr12 | 32931283 | WNT1 | 7471 | 0.04 | trans | ||
rs11176643 | chr12 | 67629785 | WNT1 | 7471 | 2.839E-6 | trans | ||
rs17764482 | chr12 | 82483756 | WNT1 | 7471 | 0.06 | trans | ||
rs7963156 | chr12 | 97472647 | WNT1 | 7471 | 0.18 | trans | ||
rs17026331 | chr12 | 97478907 | WNT1 | 7471 | 0 | trans | ||
rs11066476 | chr12 | 113465366 | WNT1 | 7471 | 0 | trans | ||
rs12312224 | chr12 | 129771735 | WNT1 | 7471 | 0.16 | trans | ||
rs17069275 | chr13 | 47573172 | WNT1 | 7471 | 0.16 | trans | ||
rs7322001 | chr13 | 94895345 | WNT1 | 7471 | 0.14 | trans | ||
rs17793815 | chr14 | 22794531 | WNT1 | 7471 | 0.04 | trans | ||
rs11158850 | chr14 | 70757171 | WNT1 | 7471 | 0.04 | trans | ||
rs8010077 | chr14 | 75242784 | WNT1 | 7471 | 0.16 | trans | ||
rs1862127 | chr14 | 78407295 | WNT1 | 7471 | 0.11 | trans | ||
rs17120009 | chr14 | 84924155 | WNT1 | 7471 | 0.06 | trans | ||
rs3790050 | chr14 | 94421666 | WNT1 | 7471 | 0.18 | trans | ||
rs11635209 | chr15 | 32333996 | WNT1 | 7471 | 0.12 | trans | ||
rs8043232 | chr15 | 41282370 | WNT1 | 7471 | 0.03 | trans | ||
rs4468583 | chr15 | 41328652 | WNT1 | 7471 | 0.03 | trans | ||
rs2412599 | chr15 | 41347970 | WNT1 | 7471 | 0.03 | trans | ||
rs16971463 | chr15 | 41370625 | WNT1 | 7471 | 0.01 | trans | ||
rs518137 | chr15 | 41381512 | WNT1 | 7471 | 0.01 | trans | ||
rs11072201 | chr15 | 70857175 | WNT1 | 7471 | 0.01 | trans | ||
rs17781350 | chr15 | 71108134 | WNT1 | 7471 | 0 | trans | ||
rs7200513 | chr16 | 17219474 | WNT1 | 7471 | 0.15 | trans | ||
rs3829495 | chr16 | 17221986 | WNT1 | 7471 | 0.04 | trans | ||
rs16949485 | chr16 | 79104374 | WNT1 | 7471 | 0.15 | trans | ||
rs12452652 | chr17 | 72235560 | WNT1 | 7471 | 1.811E-8 | trans | ||
rs17188689 | chr18 | 23359136 | WNT1 | 7471 | 0.01 | trans | ||
rs10513931 | chr18 | 61569462 | WNT1 | 7471 | 0.06 | trans | ||
rs2469009 | chr18 | 70713334 | WNT1 | 7471 | 0.1 | trans | ||
rs17087020 | chr18 | 70828793 | WNT1 | 7471 | 0.09 | trans | ||
rs1893731 | chr18 | 70954644 | WNT1 | 7471 | 0.16 | trans | ||
rs17056775 | chr18 | 72988809 | WNT1 | 7471 | 0 | trans | ||
rs321929 | chr19 | 52835463 | WNT1 | 7471 | 0.14 | trans | ||
rs10485563 | chr20 | 16813100 | WNT1 | 7471 | 0.02 | trans | ||
rs1523533 | chr20 | 51329866 | WNT1 | 7471 | 0.03 | trans | ||
rs2689370 | chr20 | 51335422 | WNT1 | 7471 | 0.11 | trans | ||
rs2745070 | chr20 | 51337694 | WNT1 | 7471 | 0.11 | trans | ||
rs402866 | chr21 | 28531675 | WNT1 | 7471 | 0.15 | trans | ||
rs5992705 | chr22 | 17914003 | WNT1 | 7471 | 0.11 | trans | ||
rs13057846 | chr22 | 26291756 | WNT1 | 7471 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
DHX15 | 0.95 | 0.97 |
GPBP1 | 0.95 | 0.96 |
PRPF4B | 0.95 | 0.97 |
PAPOLA | 0.95 | 0.96 |
SUZ12 | 0.95 | 0.97 |
MSH2 | 0.95 | 0.95 |
YME1L1 | 0.94 | 0.95 |
NUP133 | 0.94 | 0.97 |
METTL14 | 0.94 | 0.94 |
UHRF2 | 0.94 | 0.96 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MT-CO2 | -0.75 | -0.88 |
FXYD1 | -0.75 | -0.87 |
AF347015.31 | -0.74 | -0.86 |
AF347015.33 | -0.73 | -0.85 |
IFI27 | -0.73 | -0.86 |
AF347015.27 | -0.72 | -0.84 |
MT-CYB | -0.72 | -0.84 |
AF347015.8 | -0.72 | -0.86 |
HLA-F | -0.70 | -0.77 |
HIGD1B | -0.70 | -0.84 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005102 | receptor binding | NAS | Neurotransmitter (GO term level: 4) | 15592430 |
GO:0004871 | signal transducer activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007417 | central nervous system development | TAS | Brain (GO term level: 6) | 2202907 |
GO:0022004 | midbrain-hindbrain boundary maturation during brain development | IEA | Brain (GO term level: 12) | - |
GO:0048664 | neuron fate determination | IEA | neuron (GO term level: 10) | - |
GO:0001708 | cell fate specification | TAS | 15592430 | |
GO:0007223 | Wnt receptor signaling pathway, calcium modulating pathway | IEA | - | |
GO:0007163 | establishment or maintenance of cell polarity | TAS | 15592430 | |
GO:0007275 | multicellular organismal development | IEA | - | |
GO:0016477 | cell migration | TAS | 15592430 | |
GO:0030154 | cell differentiation | TAS | 15592430 | |
GO:0042472 | inner ear morphogenesis | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005576 | extracellular region | IEA | - | |
GO:0005578 | proteinaceous extracellular matrix | IEA | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG WNT SIGNALING PATHWAY | 151 | 112 | All SZGR 2.0 genes in this pathway |
KEGG HEDGEHOG SIGNALING PATHWAY | 56 | 42 | All SZGR 2.0 genes in this pathway |
KEGG MELANOGENESIS | 102 | 80 | All SZGR 2.0 genes in this pathway |
KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
KEGG BASAL CELL CARCINOMA | 55 | 44 | All SZGR 2.0 genes in this pathway |
BIOCARTA ALK PATHWAY | 37 | 29 | All SZGR 2.0 genes in this pathway |
BIOCARTA GSK3 PATHWAY | 27 | 26 | All SZGR 2.0 genes in this pathway |
BIOCARTA PITX2 PATHWAY | 15 | 15 | All SZGR 2.0 genes in this pathway |
BIOCARTA PS1 PATHWAY | 14 | 14 | All SZGR 2.0 genes in this pathway |
BIOCARTA WNT PATHWAY | 26 | 24 | All SZGR 2.0 genes in this pathway |
WNT SIGNALING | 89 | 71 | All SZGR 2.0 genes in this pathway |
PID PS1 PATHWAY | 46 | 39 | All SZGR 2.0 genes in this pathway |
PID WNT SIGNALING PATHWAY | 28 | 23 | All SZGR 2.0 genes in this pathway |
PID CMYB PATHWAY | 84 | 61 | All SZGR 2.0 genes in this pathway |
REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 88 | 58 | All SZGR 2.0 genes in this pathway |
REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | All SZGR 2.0 genes in this pathway |
THEODOROU MAMMARY TUMORIGENESIS | 31 | 24 | All SZGR 2.0 genes in this pathway |
BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
SHIN B CELL LYMPHOMA CLUSTER 6 | 11 | 9 | All SZGR 2.0 genes in this pathway |
NADLER HYPERGLYCEMIA AT OBESITY | 58 | 35 | All SZGR 2.0 genes in this pathway |
KONDO PROSTATE CANCER HCP WITH H3K27ME3 | 97 | 72 | All SZGR 2.0 genes in this pathway |
DE YY1 TARGETS UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
VART KSHV INFECTION ANGIOGENIC MARKERS UP | 165 | 118 | All SZGR 2.0 genes in this pathway |
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 | 349 | 234 | All SZGR 2.0 genes in this pathway |
MIKKELSEN IPS WITH HCP H3K27ME3 | 102 | 76 | All SZGR 2.0 genes in this pathway |
MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |
NABA SECRETED FACTORS | 344 | 197 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
let-7/98 | 227 | 233 | m8 | hsa-let-7abrain | UGAGGUAGUAGGUUGUAUAGUU |
hsa-let-7bbrain | UGAGGUAGUAGGUUGUGUGGUU | ||||
hsa-let-7cbrain | UGAGGUAGUAGGUUGUAUGGUU | ||||
hsa-let-7dbrain | AGAGGUAGUAGGUUGCAUAGU | ||||
hsa-let-7ebrain | UGAGGUAGGAGGUUGUAUAGU | ||||
hsa-let-7fbrain | UGAGGUAGUAGAUUGUAUAGUU | ||||
hsa-miR-98brain | UGAGGUAGUAAGUUGUAUUGUU | ||||
hsa-let-7gSZ | UGAGGUAGUAGUUUGUACAGU | ||||
hsa-let-7ibrain | UGAGGUAGUAGUUUGUGCUGU | ||||
miR-130/301 | 260 | 266 | m8 | hsa-miR-130abrain | CAGUGCAAUGUUAAAAGGGCAU |
hsa-miR-301 | CAGUGCAAUAGUAUUGUCAAAGC | ||||
hsa-miR-130bbrain | CAGUGCAAUGAUGAAAGGGCAU | ||||
hsa-miR-454-3p | UAGUGCAAUAUUGCUUAUAGGGUUU | ||||
miR-140 | 168 | 174 | m8 | hsa-miR-140brain | AGUGGUUUUACCCUAUGGUAG |
miR-148/152 | 261 | 267 | m8 | hsa-miR-148a | UCAGUGCACUACAGAACUUUGU |
hsa-miR-152brain | UCAGUGCAUGACAGAACUUGGG | ||||
hsa-miR-148b | UCAGUGCAUCACAGAACUUUGU | ||||
miR-19 | 685 | 691 | m8 | hsa-miR-19a | UGUGCAAAUCUAUGCAAAACUGA |
hsa-miR-19b | UGUGCAAAUCCAUGCAAAACUGA | ||||
miR-34/449 | 263 | 269 | m8 | hsa-miR-34abrain | UGGCAGUGUCUUAGCUGGUUGUU |
hsa-miR-34c | AGGCAGUGUAGUUAGCUGAUUGC | ||||
hsa-miR-449 | UGGCAGUGUAUUGUUAGCUGGU | ||||
hsa-miR-449b | AGGCAGUGUAUUGUUAGCUGGC |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.