Gene Page: XRCC1

Summary ?
GeneID7515
SymbolXRCC1
SynonymsRCC
DescriptionX-ray repair complementing defective repair in Chinese hamster cells 1
ReferenceMIM:194360|HGNC:HGNC:12828|Ensembl:ENSG00000073050|HPRD:01909|Vega:OTTHUMG00000182699
Gene typeprotein-coding
Map location19q13.2
Pascal p-value0.802
Sherlock p-value0.851
Fetal beta0.392
SupportG2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003684damaged DNA bindingIEA-
GO:0005515protein bindingIPI14755728 |15044383 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000012single strand break repairIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP8978692 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APEX1APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1APEX nuclease (multifunctional DNA repair enzyme) 1-HPRD,BioGRID11707423 
APTXAOA | AOA1 | AXA1 | EAOH | EOAHA | FHA-HIT | FLJ20157 | MGC1072aprataxinAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID15044383 |15555565 
APTXAOA | AOA1 | AXA1 | EAOH | EOAHA | FHA-HIT | FLJ20157 | MGC1072aprataxinAPTX interacts with XRCC1.BIND15555565 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD11352725 
LIG3LIG2ligase III, DNA, ATP-dependent-HPRD,BioGRID8264637 |9136882 
|9705932 |11163244 
NEIL1FLJ22402 | FPG1 | NEI1 | hFPG1nei endonuclease VIII-like 1 (E. coli)XRCC1 interacts with Neil1.BIND15260972 
NEIL1FLJ22402 | FPG1 | NEI1 | hFPG1nei endonuclease VIII-like 1 (E. coli)-HPRD,BioGRID15260972 
OGG1HMMH | HOGG1 | MUTM | OGH18-oxoguanine DNA glycosylaseReconstituted Complex
Two-hybrid		BioGRID12933815 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9584196 |15044383 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1-HPRD9584196 |14500814 
PARP2ADPRT2 | ADPRTL2 | ADPRTL3 | PARP-2 | pADPRT-2poly (ADP-ribose) polymerase 2Affinity Capture-WesternBioGRID11948190 
PCNAMGC8367proliferating cell nuclear antigenAffinity Capture-Western
Co-localization
FRET
Reconstituted Complex		BioGRID15107487 
PNKPPNKpolynucleotide kinase 3'-phosphataseAffinity Capture-MS
Affinity Capture-Western
Far Western
Two-hybrid		BioGRID11163244 |17353931 
PNKPPNKpolynucleotide kinase 3'-phosphatasePhosphorylated XRCC1 interacts with PNK.BIND15066279 
POLBMGC125976polymerase (DNA directed), beta-HPRD,BioGRID8978692 |11467963 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID15044383 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG BASE EXCISION REPAIR 3522All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY 4030All SZGR 2.0 genes in this pathway
REACTOME BASE EXCISION REPAIR 1913All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 11259All SZGR 2.0 genes in this pathway
REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY 127All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 11578All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3 4831All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 4628All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 3731All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESISTANCE 2014All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway